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P Dey

Publications and source records attributed to P Dey.

At least 19 recordsLinked to original sources
PubMed1997

Fine-needle aspiration biopsy in fungal infections.

To evaluate the role of fine-needle aspiration biopsy (FNAB) in diagnosis of fungal infections, a retrospective analysis of 26 cases of fungal infection is described. The spectrum of various fungi encountered on cytologic microscopy of aspirated material and fungal culture was as follows: Aspergillus sp (16 cases), Cryptococcus neoformans (six cases), Mucorales (one case), Candida sp (one case), Phialophora parasiticus (one case), Sporothrix schenkii and Cladosporium sp (the last two isolated from a single case). In majority (71%) of cases, fungal infection was not clinically suspected but was picked up on cytologic material in all the cases. An accurate diagnosis based on morphology could be made in 21 cases (80%). Predisposing factor was found in three patients, two of them had diabetes mellitus and one was on immunosuppression. HIV serology was negative in seven cases tested. Commonest tissue reaction (75%) was foreign body giant cells with foamy macrophages and variable amount of necrosis. Although FNAB is helpful in the rapid diagnosis of fungal infections, culture is essential for more accurate identification.

Adolescent↗
PubMed1997

Fine needle aspiration (FNA) cytology of extra-adrenal paragangliomas.

We studied nine histologically proved cases of extra-adrenal paragangliomas. Of these, eight cases were correctly diagnosed preoperatively by FNA cytology. Salient cytological features included clusters and discretely scattered cells, with occasional acinar configuration. The cells showed moderate to abundant slightly basophilic cytoplasm with ill-defined margins and round to oval nuclei with mild to marked nuclear pleomorphism. Fine reddish intracytoplasmic granules were also noted (six cases). Cytological features along with clinical data are quite diagnostic of paragangliomas. A correct preoperative cytological diagnosis helps to prevent undue surgical complications.

Adult↗
PubMed1997

Completeness of reporting on prognostic factors for breast cancer: a regional survey.

BACKGROUND: Effective management of breast cancer is dependent on adequate pathological reporting of the surgical specimen. OBJECTIVE: To describe the frequency with which histopathological features of known prognostic importance are routinely recorded. STUDY POPULATION: 885 cases of invasive breast cancer diagnosed in NHS laboratories in Lancashire and Greater Manchester. METHODS: Pathology reports were reviewed for details for tumour histological type, size, and grade, the presence or absence of tumour in blood or lymphatic vascular channels, and a comment on the proximity of tumour to the lines of surgical excision. Laboratories were categorised according to their throughput of cases of breast cancer, involvement in the breast screening programme, and whether they were attached to a teaching hospital. RESULTS: Histological type, tumour size, presence or absence of tumour in vascular channels, and adequacy of excision were recorded for 843 (95%), 803 (91%), 436 (49%), and 761 (86%) cases, respectively. Non-screening and low throughput laboratories were significantly less likely to record certain histopathological features. No significant differences were observed between teaching and non-teaching hospitals. CONCLUSIONS: The substantial interlaboratory variation in the histopathological reporting of breast cancers can, in part, be related to throughput of cases and involvement in the breast screening programme.

Adult↗
PubMed1997

Wegener's presenting as submandibular swelling.

We describe a patient in whom bilateral swelling of submandibular glands was the initial manifestation of limited Wegener's disease. The diagnosis was based on positive anti-neutrophil cytoplasmic antibody [C-ANCA], dense inflammatory infiltrate predominantly of lymphocytes in submandibular glands, presence of non-caseating ill-formed granulomas in transbronchial biopsy and resolution of symptoms following immuno-suppressive treatment.

Antibodies, Antineutrophil Cytoplasmic↗
PubMed1997

Recent epidemiological status of malaria in Calcutta Municipal Corporation area, West Bengal.

In Calcutta, Plasmodium falciparum cases and death due to malaria show remarkably increasing trend since 1990. The incidence of P. falciparum malaria has increased more than eleven folds in 1996 in comparison to 1990, with 0, 0, 0, 3, 7, 52 and 17 deaths in 1990, 1991, 1992, 1993, 1994, 1995 and 1996 respectively. Situation is more serious than what it is projected in official records as annual blood examination rate (ABER) in Calcutta Municipal area is poor, varying from 1.5 to 3.9 in 1993 and 1996 respectively. This is further evident from the fact that in a study area in 19 months (January 1995 to July 1996) the slide positivity rate (SPR) was 47.94% on an average 28.72% suffer from P. falciparum infection (as low as 0.5% in June 1996 and as high as 71.5% in November 1996). For the first time resistance of P. falciparum to chloroquine has been noted at RII and RIII level. The response of the same parasite strain to sulfa-pyrimethamine combination drug is very much promising. Fresh infection is occurring in all the months of the year and the favourable period is from July to November 1995 that is corroborating with Container index and Breteau index related to the vector mosquito Anopheles. Susceptibility status of An. stephensi indicates that the mosquito species has acquired resistance to DDT, BHC, propoxure and malathion but is still susceptible to fenthion and deltamethrin.

Animals↗
PubMed1996

Adequacy of cervical cytology sampling with the Cervex brush and the Aylesbury spatula: a population based randomised controlled trial.

OBJECTIVE: To compare the adequacy of cervical cytology sampling with two sampling instruments commonly used in primary care-namely, the Aylesbury spatula and the Cervex brush. DESIGN: Pair matched, population based randomised controlled trial. SETTING: 86 general practices and family planning clinics in Greater Manchester. SUBJECTS: 15 882 cervical smears taken from women aged 20-64 years as part of the national cervical screening programme. INTERVENTIONS: Participating centres were allocated to sample with either the Cervex brush or the Aylesbury spatula. MAIN OUTCOME MEASURE: Inadequate smear rate. RESULTS: 5.4% and 5.5% (433/8086 and 426/7796) of smears taken with the Cervex brush and the Aylesbury spatula respectively were reported as inadequate (odds ratio 0.95; 95% confidence interval 0.74 to 1.22). CONCLUSION: The Cervex brush offers no advantage over the Aylesbury spatula in reducing inadequate smear rates in the primary care setting.

Adult↗
PubMed1996

Fine-needle aspiration biopsy of angio-immunoblastic lymphadenopathy.

In this article, we have described the fine-needle aspiration biopsy (FNAB) of five cases of angioimmunoblastic lymphadenopathy (AILD). FNAB of these cases showed large number of capillary fragments, along with polymorphous population of cells consisting of plenty of immunoblasts, plasma cells, eosinophils, and mast cells. Two cases showed clusters of clear cells. It is essential to have detailed clinical features for FNAB diagnosis of AILD. Histopathology is advisable in all the fresh cases. FNAB is helpful for screening and follow-up of AILD.

Adult↗
PubMed1996

Carcinocythemia.

Explore the source record for details and available documents.

Biopsy, Needle↗
PubMed1995

Role of AgNOR in diagnosis of thyroid follicular neoplasms on fine-needle aspiration smears.

This is a retrospective study to examine the role of AgNOR in differentiating thyroid follicular carcinoma and adenoma preoperatively on fine-needle aspiration (FNA) smears. Nineteen histopathology-proven cases of follicular adenoma and carcinoma were selected for this study. May-Grünwald-Giemsa-stained smears were destined and AgNOR staining technique was employed. Significant differences of AgNOR values were observed among follicular carcinoma versus adenoma (P < .05) and follicular carcinoma versus control cases (P < .01). Thereby the AgNOR technique may have some role in differentiating between benign and malignant follicular neoplasms of thyroid.

Adenocarcinoma, Follicular↗
PubMed1994

Fine-needle aspiration of plasma cell disorders: special emphasis on plasma cell subtype.

Fine-needle aspiration cytology and clinical presentations of 16 cases of plasma cell dyscrasias (PCD) have been studied in a period of 6 yr. There were seven cases of solitary plasmacytomas of bones, two cases of extramedullary plasmacytomas, and seven cases of multiple myelomas. Differential counts of mature and immature plasma cells along with presence of cell clumps, mitosis, and bi/multinucleations were studied. The cytological findings revealed no correlation with the different subtypes of PCDs; however, it was helpful in the differential diagnosis. Bone marrowing findings, immunological parameters, available histopathology, and X-ray appearances were analysed. Clinical diagnosis of PCDs were made in only three cases. Thus fine-needle aspiration biopsy was considered as an important diagnostic modality in tissue diagnosis of plasma cell tumors, particularly in solitary plasmacytoma of bone and extramedullary plasmacytoma.

Adult↗
PubMed1994

Nifedipine-induced analgesia after epidural injection in rats.

We explored the analgesic effect of epidural nifedipine in male Sprague-Dawley rats. By using an implanted epidural catheter, the rats were given 35 microL of dimethylsulfoxide (DMSO) alone or DMSO containing 2.5, 5, 10, or 20 microM of nifedipine. Analgesia was measured by tailflick (TF) involving spinal reflexes, and by hotplate (HP) requiring an intact central nervous system. The latencies were recorded up to 120 min after the injection. The cutoff time of the noxious stimuli was 20 s in the TF and 60 s in the HP to prevent tissue damage. The TF technique revealed a significant difference from the control at doses of 5, 10, and 20 microM with no difference among the groups. Maximum latencies (cutoff time) lasted for 15, 30, and 40 min at doses of 5, 10, and 20 microM, respectively. The HP technique disclosed a dual effect: a significant decrease at the dose of 2.5 microM, no effect at 5 microM, and an increase at 10 and 20 microM. However, the median latency did not reach the cutoff time. We conclude that nifedipine, given epidurally, possesses antinociceptive properties at the dose of 5 microM and higher, detected better by the TF than HP. Our data suggest that the antinociceptive effect of nifedipine, at the studied doses, is more prominent at the spinal than the supraspinal level.

Analgesia, Epidural↗
PubMed1994

Fine needle aspiration biopsy of pancreas.

Percutaneous fine needle aspiration biopsy (FNAB) were performed in 22 cases of pancreatic lesions. FNAB was done with the help of ultrasonographic guidance in 14 cases and intraoperatively in 2 cases. In rest of the cases it was done without any radiological guidance. Diagnosis was confirmed either by histopathology or exploratory laparotomy by follow-up data in rest of the cases. There was no false positive or negative diagnosis. Nuclear crowding, nuclear enlargement and prominent nucleoli were the important cytological criteria for pancreatic adenocarcinoma. Cytology smears of the islet cell tumour show round to oval monomorphic cells with central to eccentric nuclei and fine reddish granulations in cytoplasm. There was no complication following aspiration. Thus FNAB of pancreas is a relatively safe, reliable and quick technique which can be performed under ultrasound guidance.

Adolescent↗