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P Diblík

Publications and source records attributed to P Diblík.

13 recordsLinked to original sources
PubMed2006

[Infliximab in the treatment of Wegener's granulomatosis: case report].

PURPOSE: to evaluate the efficacy of monoclonal anti-tumor necrosis factor alpha antibody infliximab in treatment of refractory Wegene's granulomatosis. Clinical manifestations of Wegener's granulomatosis at the time of infliximab initiation were: proptosis of both eyes due to progressive retrobulbar granulomas, visual impairment, optic disc edema, progressive diplopia, sinus and renal involvement. The disease was refractory to a treatment with various immunosuppressants, including intravenous cyclophosphamide or high doses of mycophenolate mofetil in combination with corticosteroids. METHODS: Observational case report. RESULTS: the patient received six infusions of infliximab (3 mg/kg) in addition to low doses of oral cyclophosphamide and corticosteroids. The interval between the first two infusions was 1 week. The interval between the second and third infusions was 4 weeks, thereafter 8, 12 and 34 weeks. Following the third infusion of infliximab the remission of Wegener's granulomatosis was seen. After the regression of retrobulbar granulomas visual acuity increased, ocular motility improved, diplopia and optic disc edema decreased. Remission has been maintained for 17 months. Infliximab was well tolerated during the short-term follow-up. CONCLUSION: Infliximab successfully induced remission in case of sight-threatening Wegener's granulomatosis in our patient. It seems that infliximab provides more effective therapeutic option in treatment of Wegener's granulomatosis refractory to standard immunosuppression and offers better perspectives for patients with previously poor prognosis. Furthermore, it enables reducing the exposure to immunosuppressive drugs.

Antibodies, Monoclonal↗
PubMed2004

[Phacoemulsification of cataracts after pars plana vitrectomy (comparison of phacoemulsification with pars plana infusion and without pars plana infusion)].

PURPOSE: To compare peroperative complications of standard phaco technique and phaco with pars plana infusion performed for cataract after pars plana vitrectomy. METHOD: This prospective study randomly divided group of 64 patients with cataract after PPV into group A (standard phaco, 38 patients) and group B (phaco with par olana infusion, 26 patients). The study verifies the rate of peroperative complications such as deep anterior chamber, diaphragma movement miosis, and zonular dehiscention in these two groups. RESULTS: Peroperative complications had slightly higher rate in group B (with infusion). No specific complication in group A (standard phaco) was found. CONCLUSION: Standard phaco technic without par plana infusion has at least the same level of safety as phaco with pars plana infusion.

Humans↗
PubMed2003

[Importance of diagnostic and therapeutic pars plana vitrectomy in endogenous uveitis].

OBJECTIVE: To evaluate the importance of diagnostic-therapeutic pars plana vitrectomy in patients with clinical manifestations of endogenous uveitis. PATIENTS AND METHODS: The diagnostic-therapeutic pars plana vitrectomy (DT PPV) has been performed at the Eye Clinic of General Faculty Hospital and 1st Medical Faculty on Prague on 62 eyes in 49 patients at the mean age of 45 years. The DT PPV was indicated in patients with uveitis of unusual clinical picture or poorly reacting to treatment, suspected infection or tumor etiology. In the beginning of PPV, 0.5 to 1.5 ml of undiluted vitreous body was samples and subsequently examined by microbiology, immunology and molecular genetic methods. PPV was performed on both eyes in 10 patients, on one eye twice in each of three patients. The authors evaluated 62 samples of vitreous body on the whole. The patients were observed for up to 96 months. RESULTS: Laboratory examination of the samples of vitreous body from 22 eyes (35.4%) supported our notion on infection etiology of intraocular inflammation, manifestations of intraocular tumor were in 12 eyes (19.3%), vascular or vitreoretinal pathology was present in 6 eyes (9.6%). Nonspecific inflammatory changes were detected in 22 eyes (35.4%). Drugs were administered into the vitreous body in 16 eyes. In the observation period the authors detected marked late complications in connection with DD PPV in 18 eyes (29%). Visual acuity improved by two or more lines of the Snellen optotypes in 43 eyes (69.3%), remained unchanged in 11 (17.7%) eyes. The vision deteriorated in 8 eyes (12.9%). CONCLUSION: Based on this experience the authors are of the opinion that DT PPV is indicated in patients with uveitis for giving more precision to the diagnosis of intraocular inflammation or a masking syndrome. DT PPV also represents a therapeutic procedure to cure complications connected with a severe form of inflammation and makes it possible to save central visual acuity.

Adolescent↗
PubMed2001

[Mucoceles of paranasal sinuses].

In a retrospective study authors refer to the treatment results in four patients with mucocele of the paranasal sinuses, who were hospitalized during a 30-months period at the Department of Otorhinolaryngology of the Charles University Hospital, in Prague, Czech Republic. In all patients the frontal sinus was involved, in three cases the involvement was unilateral, in one case bilateral. In the medical history of all patients, an injury, inflammation, or surgery of the paranasal sinus in the past (5-30 years ago) were present. In three patients, proptosis of the eye, swollen upper eyelid, and diplopia were discovered firstly by ocular examination. All patients underwent external approach surgical treatment, in four cases it was the frontoethmoidectomy sec. Jansen-Ritter, in one case the osteoplastic frontal craniotomy was performed. The postoperative follow-up period is 2-30 months.

Adult↗
PubMed2001

[Cataract surgery in eyes treated with vitrectomy for idiopathic macular holes].

The authors evaluated the final functional results in 30 eyes where on account of nuclear and cortical cataract an intraocular lens was implanted. The operation was preceded by pars plana vitrectomy (PPV) with internal gas tamponade on account of an idiopathic macular hole (IMD). The cataract the development of which was recorded in 57 eyes was the manifestation of a late postoperative complication from a total number of 84 phakic eyes (67.9%) which were operated on account of IMD between April 1996 and June 1999. After cataract surgery the corrected visual acuity improved in 23.3% eyes. The investigation confirmed improvement and stabilization of the final corrected visual acuity in 24 eyes (80%) and confirmed the importance of these surgical procedures.

Aged↗
PubMed1996

[Ambulatory cataract surgery].

The authors present an account of the experience with the first one hundred out patient cataract surgery which were performed at the Second ophthalmological Clinic in 1993 and 1994. They found that the only absolute contraindication is the need to administer general anaesthesia and they discuss the main problems which ensue from the present state of the health services and society as a whole.

Ambulatory Surgical Procedures↗
PubMed1995

[ProVisc--a new viscoelastic material for surgery of the anterior segment. A multicenter clinical study].

Within the framework of a multicentric clinical study which was implemented at nine selected departments a new viscoelastic material ProVisc of Alcon company was tested during extracapsular extraction of cataract with implantation of posterior chamber intraocular lenses. A total of 100 eyes of 100 patients were operated and all pre- and postoperative data were recorded in uniform protocols. The selection of suitable patients and the type of surgical procedure was within the responsibility of the surgeon. The type and frequency of surgical and postoperative complications was similar as when other viscoelastic material ProVisc can be recommended as safe and effective in modern surgery of cataract.

Anterior Eye Segment↗
PubMed1992

[Botulinum toxin in the treatment of blepharospasm. Initial experience].

The clinical effects of botulinum toxin A were evaluated in eight patients with idiopathic blepharospasm and hemifacial spasm. A substantial reduction or disappearance of muscle spasms were observed after the treatment. The action of botulinum toxin became noticeable 2 days after administration with a peak effect at 2 weeks. This effect diminished with muscle spasms returning about 12 weeks after administration. No serious adverse events were noted. The treatment with botulinum toxin has become method of choice in blepharospasm, it is proposed for the management of local muscle spasms of various origin.

Adult↗
PubMed1991

[New views on treatment of intraocular foreign bodies].

The authors evaluated the results of surgery in 130 patients operated at the Second Ophthalmological Clinic in 1983-1989 on account of intraocular foreign bodies. Extraction of the body was successful in 126 patients (96%), the function of the eye was preserved in 102 of 126 extracted foreign bodies (81%), a visual acuity of 0.5 to 1.0 was recorded in 78 eyes (60%). The authors investigated the relationship of functional results on the type, size and site of the intraocular foreign body, the way of extraction, interval between the injury and operation and previous attempted extractions. Analysis of results revealed the advantages of extraction of intraocular foreign bodies under visual control in the majority of foreign bodies. Intraocular foreign bodies are not an indication for immediate but for early operation. After careful treatment of the wound where the foreign body penetrated extraction may be delayed for several days before optimal conditions for surgery are created.

Adolescent↗
PubMedDate not supplied

Management of posterior segment foreign bodies and long-term results.

The management of 158 posterior segment intraocular foreign bodies (IOFB) was retrospectively analyzed: transscleral magnet extraction via the pars plana was used for 40 magnetic IOFB, transscleral extraction via the IOFB bed for 35 magnetic and 4 non-magnetic IOFB, pars plana vitrectomy (PPV) for 44 magnetic and 32 non-magnetic IOFB, and open-sky vitrectomy for 3 non-magnetic IOFB. Final visual acuity of 0.02 and better was achieved in 104 out of 119 magnetic IOFB (87%) and 24 out of 39 non-magnetic IOFB (62%), and final visual acuity 0.05 and better in 79 magnetic IOFB (66%) and 17 non-magnetic IOFB (44%). Transscleral extraction via the IOFB bed under ophthalmoscopic control and IOFB removal by PPV proved to be the operations of choice for an increasing number of IOFB. For magnetic IOFB, these techniques yielded better final functional results than transscleral magnet extraction via the pars plana. Final visual acuity did not depend on the interval between injury and IOFB removal, and with regard to the risk of endophthalmitis, IOFB need not be considered an absolute indication for immediate intervention. IOFB size up to 5 mm2 and initial visual acuity of 0.5 and better were significant positive factors for both magnetic and non-magnetic IOFB.

Adolescent↗