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Biomedical subjects

P Diosi

Publications and source records attributed to P Diosi.

At least 19 recordsLinked to original sources
PubMed1998

[Solving the mystery of cellular inclusions. A contribution to the history of virology].

In the middle of the 19th century cell inclusions were observed with increasing frequency in more and more diseases and were closely scrutinized by researchers working in different fields. Because of their distinct viewpoints, however, the various authors came inevitably to different conclusions. The morphologists interpreted the inclusions as artefacts or degenerative changes, the etiologists, on the other hand, took them for pathogenic protozoa, for cellular lesions inflicted by invisible agents or, conversely--for aggregated products of the cellular defense. Various morphological, parasitological and bacteriological methods have been used to clear up the pros and cons of these hypotheses. It was the rapid progress realized in virology at the middle of the 20th century that finally brought to light their real significance.

Animals↗
PubMed1997

[Albert Jesionek tracking cytomegalovirus disease].

The first publications concerning the peculiar cellular structures that later-on became the hallmark of cytomegalic inclusion disease, originated in the early 20th century from German institutes. These early reports got into oblivion even before their significance and implications could be fully realized. The purpose of this study is to reconsider the contributions of Jesionek and other authors to the discovery of the "protozoa-like structures", based upon their publications and in accordance with the state of knowledge at that time.

Cytomegalovirus↗
PubMed1996

[Tietze and cytomegalovirus infection of the salivary glands].

Tietze has observed in 1898 the presence of peculiar huge cells in a tumor excised from the parotid gland of an infant. He held the structures for protozoan parasites immigrated from the oral cavity, but they turned out to be cytomegalic inclusion cells. Hence, the first description of cytomegaly-associated symptomatic illness dates back to Tietze's paper. It appears that he was the first author to establish the diagnosis in vivo, and his patient was the first one reported having survived this disease.

Cytomegalovirus↗
PubMed1996

[Doctor Anglas' observations on the presence of cytomegalic cells in macerated fetal tissues].

Early in this century, Anglas had observed in the renal tubules of a macerated fetus unusual giant structures, which turned out to be cytomegalic inclusion cells. But since he omitted to distinguish them by a suggestive term from previously known giant cells, his observation felt into oblivion. Yet, it constituted the first report on the occurrence of cytomegaly in France, and in general, the first indication of the histogenic origin of these cells, as well as of their resistance to autolysis.

Cytomegalovirus Infections↗
PubMed1983

Tubular structures occurring in cells infected with herpesviruses.

Certain viruses belonging to the Herpesviridae family generate tubular structures of three distinct size ranges late in the growth cycle. The smallest tubules are about 10 to 20 nm in diameter, and are restricted to the cell nucleus, tending to form palisades of lattice-like structures. The medium sized tubular structures are about the width of a core particle, measuring 55 to 65 nm in diameter, while the larger tubular structures are the same diameter as viral capsids, about 80 to 100 nm. Both are rigid capsomered structures, which are sometimes encountered outside the cell nucleus budding onto spherical particles. The available data on some properties of the various tubular structures, as well as speculations concerning their nature and significance are briefly reviewed. Their importance is emphasized for antigen and vaccine production, as well as in differentiating herpesviruses by electron microscopy.

Animals↗
PubMed1975

Recovery of a new herpesvirus from the ground squirrel (Citellus citellus).

A new herpesvirus recovered from the kidneys of mature ground squirrels (Citellus citellus) produced an effect in tissue culture cells resembling that of herpesviruses, including the formation of multinucleated syncytia and type A intranuclear inclusions. The isolate caused latent infection in the natural host, but it proved fatal for intracerebrally inoculated suckling mice and it produced pocks on the chorioallantoic membrane of embryonated eggs. Electron-microscopic examination of infected cells revealed intranuclear virus particles exhibiting a size and ultrastructure characteristic of herpesviruses. The isolate was ether-resistant and a DNA nucleic acid type was inferred from observations on inhibition by fluorinated pyrimidine. This ground squirrel herpesvirus was found to be antigenically distinct from Herpesvirus hominis and from ground squirrel cytomegalovirus, with no detectable cross-reactivity.

Animals↗