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Biomedical subjects

P Doberský

Publications and source records attributed to P Doberský.

At least 19 recordsLinked to original sources
PubMed1981

Optimal amino acid composition of diets for patients with chronic renal failure.

When following the spectrum of plasmatic amino acids in patients with chronic renal failure in course of a six-week treatment with low-protein diets, an increase of non-essential amino acids, glycine and alanine, was observed in the case of a diet containing 20 g of proteins. A further decrease of tyrosine and threonine, which were decreased already before the therapy, suggests the presence of an effect of the reduced intake of proteins on the levels of these amino acids. High levels of methionine occurring in the case of the diet containing 20 g of proteins a day, supplemented by methionine to a minimally necessary requirement according to Rose, show different requirements) for this amino acid in patients with the chronic renal failure. A significant drop of the histidine and arginine as compared to the values before the treatment demonstrated that it is also necessary to take into account these amino acids when composing optimal amino acid formulation for uremics. A preliminary proposal is presented of a composition of amino acid mixture suitable for patients with chronic renal failure which differs essentially from the Rose formulation developed for a healthy organism. Different requirements for arginine are also considered in addition to the essential amino acids and histidine.

Adult↗
PubMed1978

Renal clearance of amino acids in patients with severe chronic renal failure.

The renal clearance of 21 amino acids was investigated in 5 patients with chronic renal failure (inulin clearance = 5--10ml/min) during the 6-week administration of a low-protein diet. The results were compared with values obtained in 6 volunteers. The renal clearance of all investigated amino acids (with the exception of Asp, His, Tau) did not differ significantly from healthy controls. The excretion fraction (amino acid clearance inulin clearance.100) was in all investigated amino acids significantly higher than in controls with the exception of Tau. The excretion fractions of Asp, Ser, Cys, Tyr, His, Thr, Tau and Gly were, on average, above 20%. The findings suggest that the fractional reabsorption of amino acids in residual nephrons is decreased.

Adult↗
PubMed1978

Influence of protein intake and renal function on plasma amino acids in patients with renal impairment and after kidney transplantation.

A group of 17 patients with chronic renal impairment and a group of 11 patients surviving for 3--7 years after kidney transplantation were examined. In all patients plasma amino acids were analyzed. The ratio of essential/nonessential amino acids, the valine/glycine ratio and Whitehead's quotient are influenced above all by the dietary protein intake. Raised citrulline and 3-methylhistidine values were not influenced by the protein intake, while they correlate with indicators of renal function. Changes detected after kidney transplantation are analogous.

Adult↗
PubMed1978

The effect of a low-protein diet on serum levels of ceruloplasmin and transferrin in patients with chronic renal failure.

In patients with chronic renal failure the administration of a diet providing 20 g protein per day for five weeks caused a significant rise in the serum ceruloplasmin level. A low dietary copper content (0.8 mg/day) may have been the limiting factor for any further rise of the ceruloplasmin level. The rise of ceruloplasmin was associated with a continuous decline of total iron binding capacity. The temporarily raised serum iron levels and the continuous decline of unsaturated iron binding capacity suggested enhanced iron mobilization caused by the raised ceruloplasmin level. The rise of ceruloplasmin correlated with the decline of UIBC.

Ceruloplasmin↗
PubMed1976

Application of mathematical optimization methods in microbiology.

Mathematical methods of experiment design have so far found little use in the optimization of microbiological processes. The conventional optimization procedure is still the transformation of functional relationship of n variables into n unidimensional optimizations; furthermore, the Box-Wilson gradient method is often used. This paper presents a review of methods used in other fields, and their application in microbiological practice. The methods are classified according to whether they require, besides the simple determination of the objective function (direct search methods), also the finding of its first (gradient methods) or second derivative (Newton-Raphson method). A modified Rosenbrock's method of direct optimum search and the gradient Box-Wilson method were used in parallel for the optimization of yeast growth on methanol. Their comparison showed that Rosenbrock's method is more suitbale for multiparameter systems.

Candida↗
PubMed1975

A new approach to evaluate the final effect of parenteral nutrition.

In patients who had undergone gastric operations, the efficacy of a parenteral rehabilitation with plasma, human albumin and Aminofusin L forte was determined by assessing the extravascular albumin pool. The intravenous administration of Aminofusin L forte thus proved to be today's safest and quickest method of protein rehabilitation.

Blood Proteins↗