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Biomedical subjects

P Dressler

Publications and source records attributed to P Dressler.

6 recordsLinked to original sources
PubMed1986

[The history of anesthesia at the Heidelberg University].

An account is given on the development of general anaesthesia at the university clinics of Heidelberg. During the last century mainly chloroform was employed for general anaesthesia. Important events were the first demonstration of Koller's local anaesthesia in the eye in 1884, the first intubation for anaesthesia in Heidelberg, performed by F. Kuhn of Kassel and the development by M. Neu of a rotameter apparatus for nitrous oxide/oxygen anaesthesia in 1910. From 1932 on the surgeon M. Kirschner advanced the methods of high pressure infiltration for regional anaesthesia and segmental hypobaric spinal anaesthesia. In 1951 K. H. Bauer requested R. Frey to set up an "anaesthesia squad" consisting of 2 physicians and 3 nurses to become the nucleus of today's Institute of Anaesthesiology, with O. H. Just as its first professor and chairman.

Anesthesia↗
PubMed1982

[Combined use of dihydralazine and nitroglycerin during and after cardiac surgery (author's transl)].

The haemodynamic effect of combined intravenous administration of 18 mg/h dihydralazine and 0.6 mg/h nitroglycerine was examined in the intraoperative and postoperative phases of cardiac surgery (replacement of the aortic and mitral valve or of both valves, and aortocoronary bypass surgery(. Indication for therapy was supplied by a preoperative cardiac index below 2.8 l/min . m2 and an enhanced peripheral resistance above 1200 dyne . sec . cm-5. During a 19-hour observation period the haemodynamic parameters such as cardiac index (+36%) and stroke index (+19%) increased significantly within the investigated group, whereas the peripheral vascular resistance dropped by 16% and the left atrial pressure by 20%. Arterial mean pressure and heart rate did not change. In a patient group treated exclusively with nitroglycerin, the cardiac index decreased (-8%), while the peripheral vascular resistance increased (+6%); an untreated control group showed an increase of the cardiac index by 5%, whereas there was no appreciable change in peripheral vascular resistance and stroke index. The combined use of dihydralazine and nitroglycerin during the perioperative phase of cardiac surgery appears recommendable, since it is possible by such administration to monitor cardiac preload and afterload due to selectivity of the pharmacological sites of action.

Adult↗
PubMed1981

Experimental studies on microcirculation under normobaric hyperoxia using the microspheres method.

The perfusion of the heart, kidneys, adrenals, stomach, intestines, brain and musculature under normobaric hyperoxia was studied in anaesthetized mini pigs using radioactively labelled microspheres. After a 2-hour control period using room air, the influence of normobaric hyperoxia on the perfusion of the organs was measured at 2-hour intervals. A significant increase in the perfusion of tissue was found in the kidneys, adrenals, gastro-intestinal tract and brain after 4-6 hours of exposure. No change in perfusion could be demonstrated for the myocardium. Values for the skeletal musculature (diaphragm and musculus psoas) were widely scattered, but an increase could be suspected. The increase in tissue perfusion at constant blood pressure and pulse rate must be interpreted as an expression of vasodilation. These results are contrary to the majority of statements in the literature, which mainly report vasoconstriction under normobaric hyperoxia.

Adrenal Glands↗
PubMed1979

[Studies of gastric circulation in the dog, II. Ligation of main arteries (author's transl)].

Following ligation of a single gastric artery total and regional gastric blood flows are measured using radioactive microspheres of 8 mu size. There is no significant influence on total gastric blood flow. Within the depending anatomical region no significant reduction of total wall blood flow can be determined. However, blood flow to the antrum mucosa is reduced to approximately 40% after ligation of any gastric artery. Thus, it can be concluded that ligation or embolisation of a single gastric artery in diffuse gastric bleeding does not necessarily reduce or terminate the bleeding.

Animals↗
PubMed1978

[Puncture of central veins venesection in childhood (author's transl)].

Due to advances in parenteral feeding the indications for creating access to the central veins in infants and young children have become less strict. The technique of establishing such access by puncture of the internal jugular or subclavian vein is reviewed. Venesection is now indicated only in exceptional cases. The technique of placing a catheter into the umbilical artery or vein is described.

Age Factors↗