Biomedical subjects

P E Fast

Publications and source records attributed to P E Fast.

20 records · Page 2Linked to original sources

PubMed1982

Renal lesions in MRL mice.

Female MRL-Mp-lpr/lpr mice spontaneously develop autoimmune disease at three to five months of age and die most commonly from immune complex glomerulonephritis. Kidneys of two-month-old females appeared nearly normal by electron microscopy, and glomerular deposits of IgG an complement component 3 (C3) barely were detectable. In five-month-old females, immunofluorescence revealed numerous deposits of IgG and C3; glomerular mesangial cells were hypertrophic and hyperplastic and contained electron-dense material. There were subepithelial and subendothelial deposits of electron-dense material with swelling of epithelial cell cytoplasm. This disease has many features similar to the immune complex glomerulonephritis observed in New Zealand Black and White hybrid mice and in man.

Animals↗

PubMed1982

Recovery of lymphocyte function after radiation therapy for cancer in relationship to prognosis.

The number and functional abilities of lymphocytes from patients with either breast cancer or cervical cancer were assessed before, during and after radiation therapy given to treat the disease and the patients were followed for several years. Radiation depleted both T and B cells and depressed the responses to PHA and Con-A in all patients groups. The response to mitogens in the weeks immediately following radiation therapy was greater in patients whose disease did not recur and was depressed for a much longer time in patients whose disease recurred within the next few years. This difference was most clearly reflected in the ratio of mitogen response to the number of T-cells. The relationship of responsive to non-responsive or suppressor lymphocytes in the weeks following radiation therapy may be a clue to prognosis.

Adult↗