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P E Kearney

Publications and source records attributed to P E Kearney.

2 recordsLinked to original sources

A six-point condition for ordinal matrices.

Ordinal assertions in an evolutionary context are of the form "species s is more similar to species x than the species y" and can be deduced from a distance matrix M of interspecies dissimilarities (M[s, x] < M[s, y]). Given species x and y, the ordinal binary character cxy of M is defined by cxy(s) = 1 if and only if M[s,x] < M[s, y], for all species s. In this paper we present several results concerning the inference of evolutionary trees or phylogenies from ordinal assertions. In particular, we present. A six-point condition that characterizes those distance matrices whose ordinal binary characters are pairwise compatible. This characterization is analogous to the four-point condition for additive matrices. An optimal O(n2) algorithm, where n is the number of species, for recovering a phylogeny that realizes the ordinal binary characters of a distance matrix that satisfies the six-point condition. An NP-completeness result on determining if there is a phylogeny that realizes k or more of the ordinary binary characters of a given distance matrix.

Algorithms↗

Comparison of the beta-adrenoceptor effects of soterenol and its 3-hydroxy, 4-sulphonamido isomer (MJ6987-1) in isolated tissues from the guninea-pig.

1. Soterenol and its 3-hydroxy, 4-methanesulphonamido isomer (MJ6987-1) were compared with isoprenaline for beta-adrenoceptor mediated effects in guinea-pig atrial, tracheal, uterine and ileal preparations. In addition, MJ6987-1 was tested for its effects in the atria of cats, rabbits and rats. 2. Soterenol had a lower intrinsic activity and was approximately two to six times less active than isoprenaline in all preparations. 3. MJ6987-1 was a full agonist, being some 30--200 times less active than isoprenaline at beta 1-receptor sites and greater than 3000 times less active in preparations where beta 2-receptor activation was involved. 4. Change in the position of the ring substituents in soterenol leads to the production of beta 1-receptor selective agonist.

Adrenergic beta-Agonists↗