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Biomedical subjects

P E M Smith

Publications and source records attributed to P E M Smith.

9 recordsLinked to original sources
PubMed2006

Variability of antiepileptic medication taking behaviour in sudden unexplained death in epilepsy: hair analysis at autopsy.

BACKGROUND: Variable compliance with antiepileptic drugs (AEDs) is a potentially preventable cause of sudden unexplained death in epilepsy (SUDEP). Hair AED concentrations provide a retrospective insight into AED intake variability. METHODS: We compared hair AED concentration variability in patients with SUDEP (n = 16), non-SUDEP epilepsy related deaths (n = 9), epilepsy outpatients (n = 31), and epilepsy inpatients (n = 38). AED concentrations were measured in 1 cm hair segments using high performance liquid chromatography. Individual patient hair AED concentration profiles were corrected for "washout" using linear regression analysis. The coefficient of variation (CV) of the corrected mean hair AED concentration provided an index of variability of an individual's AED taking behaviour. Hair sample numbers varied between subjects, and so weighted regression estimates of the CV were derived for each group. RESULTS: The CV regression estimates for each group were: SUDEP 20.5% (standard error 1.9), non-SUDEP 15.0% (3.9), outpatients 9.6% (1.4), and inpatients 6.2% (2.7). The SUDEP group therefore showed greater hair AED concentration variability than either the outpatient or the inpatient groups (p<0.0001). CONCLUSION: Observed variability of hair AED concentrations, reflecting variable AED ingestion over time, is greater in patients dying from SUDEP than in either epilepsy outpatients or inpatients. SUDEP, at least in a proportion of cases, appears preventable.

Adolescent↗
PubMed2005

Ocular complications of neurological therapy.

Treatments used for several neurological conditions may adversely affect the eye. Vigabatrin-related retinal toxicity leads to a visual field defect. Optic neuropathy may result from ethambutol and isoniazid, and from radiation therapy. Posterior subcapsular cataract is associated with systemic corticosteroids. Transient refractive error changes may follow treatment with acetazolamide or topiramate, and corneal deposits and keratitis with amandatine. Intraocular pressure can be elevated in susceptible individuals by anticholinergic drugs, including oxybutynin, tolterodine, benzhexol, propantheline, atropine and amitriptyline, and also by systemic corticosteroids and by topiramate. Nystagmus, diplopia and extraocular muscle palsies can occur with antiepileptic drugs, particularly phenytoin and carbamazepine. Ocular neuromyotonia can follow parasellar radiation. Congenital ocular malformations can result from in utero exposure to maternally prescribed sodium valproate, phenytoin and carbamazepine. Neurologists must be aware of potential ocular toxicity of these drugs, and appropriately monitor for potential adverse events.

Acetazolamide↗
PubMed2005

Approach to the patient with epilepsy in the outpatient department.

Epilepsy is common and serious (prevalence 750 per 100 000) and has an impact upon employment, education, and driving. The diagnosis requires a detailed history including witness account. Clinicians must distinguish seizures particularly from syncope and psychogenic attacks. Electroencephalography and magnetic resonance brain scanning help to identify causes and classification of epilepsy, but alone rarely provide the diagnosis. Antiepileptic drug treatment is required long term and is potentially hazardous; patients should start treatment only after informed discussion with an epilepsy specialist. Patients require reliable written information, particularly the driving regulations, and the impact of seizures on employment, education, and leisure. Women must understand the potential drug teratogenic effects. Certain patient groups benefit from targeted epilepsy services, for example, learning disabled, children, teenagers, and elderly. People with epilepsy require long term specialist follow up. Although this is currently provided in mainly in secondary care (including nurse led clinics), improved liaison with primary care should enable improved access to epilepsy services. Epilepsy care should be multidisciplinary and long term, linking primary and secondary care, and empowering patients towards improved management of their condition.

Ambulatory Care↗
PubMed2004

Inappropriate requests for serum anti-epileptic drug levels in hospital practice.

BACKGROUND: Serum anti-epileptic drug (AED) levels are indicated to assess AED adherence or toxicity, and are applicable to only a few AEDs. Expert consensus views on the clinical role of serum AED levels are summarized in the evidence-based guidelines published by the Scottish Intercollegiate Guidelines Network. AIM: To examine local compliance with these guidelines. DESIGN: Retrospective case-note audit. METHODS: We included all serum AED level measurements requested from our hospital over two months. Our audit standards were first, that serum AED levels should be requested only for suspicion of poor AED adherence or toxicity ('indication-compliant'), and secondly, for 'full compliance', that 'indication-compliant' requests should be made only for AEDs with established dose-response and dose-toxicity relationships (phenytoin, carbamazepine, phenobarbitone). RESULTS: There were 114 measurements in 102 patients. Serum AED level requests were for phenytoin (n = 50), valproate (n = 27), carbamazepine (n = 22), lamotrigine (n = 8), phenobarbitone (n = 7), and were made by physicians (n = 46), paediatricians (n = 30), neurologists (n = 15), neurosurgeons (n = 14), psychiatrists (n = 7), and intensivists (n = 2). AED toxicity was queried in 29 requests (25%), and adherence in 10 (9%); thus 34% of requests were 'indication-compliant'. However, 16 of these were for valproate or lamotrigine; thus only 23 requests (20%) were 'fully compliant'. Clinical management changed in only 17 of the 47 patients whose levels fell outside target ranges, and only two of these followed indication-compliant AED measurement. DISCUSSION: The audit identified a failure locally to comply with standard evidence-based guidelines. If, as is likely, this reflects practice elsewhere in the UK, there are potentially major clinical management and resource implications.

Anticonvulsants↗
PubMed2003

Tilt table testing in patients referred from an epilepsy clinic.

OBJECTIVE: To assess the role of head up tilt testing (HUT) in diagnosing probable or possible vasovagal syncope (VVS) in patients referred from an epilepsy clinic. METHODS: One hundred thirty two patients underwent HUT over 36 months. Complete data were available on 128 patients (52 male) aged 14-80 (mean 36.7) years. The main indication for HUT (head up tilt at 70 degrees for 45 minutes) was recurrent undiagnosed blackouts, likely to be VVS. Patients were divided, prior to knowledge of the HUT results, into probable VVS, possible VVS, or probable/possible VVS associated with definite epilepsy. RESULTS: HUT was positive in 72 patients (56%), and led to an alternative definite diagnosis in 31 (24%). Diagnostic change was more likely in those provisionally labelled either as possible VVS (15 of 34; 44%) or as a combination of epilepsy with possible or probable VVS (12 of 19; 63%) compared to those with probable VVS (4 of 75; 5%; P<0.01).Of the 45 patients previously treated with antiepileptic medications 27 did not have epilepsy. CONCLUSION: HUT has an important role in confirming or refuting the diagnosis of VVS in patients presenting with undiagnosed blackouts to an epilepsy clinic, and particularly so in patients with possible rather than probable VVS, and in those thought to have a combination of epilepsy and possible or probable VVS.

Adolescent↗
PubMed2002

A teenager epilepsy clinic: observational study.

Teenagers with epilepsy are a group with special needs whom we have specifically targeted in our clinical practice. All teenagers referred to our unit between 1997 and 2001 with definite or probable epilepsy, were considered for assessment by an adult neurologist and paediatric neurologist working together in a dedicated monthly clinic. A total of 207 patients aged 11-22 (mean 16.0) years, 95 male, were seen over 46 months. Epilepsy was our diagnosis in 173 (84%), classified as generalized (n=76), focal (n=70), or unclassified (n=27). Four others had had single seizures. 'Non-epilepsy' diagnoses (n=30) included vasovagal syncope in 17, non-epileptic attack disorder in six, and migraine in three; epilepsy had been erroneously diagnosed previously in eight of these. Existing antiepileptic drug treatment, or lack of it, was considered appropriate in 165 of the 207 patients. Major changes to medication made in 42 patients included new prescriptions for those previously untreated (n=28), changing type of medication (n=6), and stopping medication (n=8). Antiepileptic medication was withheld in 21 despite epilepsy or single seizure. All patients received appropriate advice on driving, contraception, and alcohol, and were offered further specialist nurse appointments. Of the 86 females on antiepileptic medication at the time of consultation, only 12 were already taking folate supplements. The clinic had an important role in confirming diagnosis, ensuring appropriate management, information provision and aiding seamless transition to adult epilepsy care.

Adaptation, Psychological↗
PubMedDate not supplied

Selecting specialist registrars by station interview.

Appointments to the specialist registrar (SpR) grade depend almost entirely on performance at interview, yet standard panel interviews do not directly assess the competences required of a medical trainee. In this study, station interviews were used to select neurology SpRs. Eighteen candidates were assessed in three interviews, each involving three stations: a curriculum vitae (CV)-based interview, an interview with a simulated patient, and a discussion of scenarios based upon teaching, audit and research. Two or three assessors at each station ranked candidates independently before discussing the pooled rankings and reading written references. The CV-based interview rankings (resembling a traditional panel interview) correlated less well with the overall rankings (r=0.54) than did research (r=0.83), information giving (r=0.75), audit (r=0.70) or teaching presentation (r=0.59). Station interviews appear fairer (providing more time, more independent examiners, fresh starts at each station), although they require more planning and expense. Competency-based assessments should be more widely used in selecting medical trainees.

Clinical Competence↗