[Tuberculous meningoencephalitis associated with tuberculosis of the adrenal glands].
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Biomedical subjects
Publications and source records attributed to P E Mazur.
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Histological postmortem examination of 30 persons who had died of pulmonary tuberculosis complicated by renal amyloidosis revealed amyloid affections in the rectum, stomach and liver of 76.3, 60 and 56.7 per cent of the dead, respectively. Histological examination of biopsy specimens of the gastric and duodenal mucosa from 20 patients with pulmonary tuberculosis revealed amyloid affections in 17 of them (85 per cent). An analogous examination of 18 patients with chronic nonspecific diseases of the lungs revealed amyloidosis of the organs in 10 persons (55.6 per cent). Efficiency of using proteinase inhibitors such as amben, epsilon-aminocapronic acid and contrical in the prevention and treatment of secondary amyloidosis of the digestive organs was studied experimentally.
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Labeled microspheres were used to measure blood flow to the leg bones of the laying hen at 0, 3, and 30 min after iv injection of parathyroid hormone (PTH) (Wilson) or the synthetic 1 to 34 fragment of bovine parathyroid hormone (PTH 1-34). At 3 min, which corresponds to the hypocalcemic phase of the PTH response, blood flow to the combined femur, tibia, and metatarus was significantly reduced by PTH (Wilson) relative to 0 time and to carrier-injected controls. At 30 min, i.e., the time of maximum hypercalcemia in the hen, blood flow to these bones was significantly increased relative to 0 time. The results obtained with PTH 1-34 were similar, except that the decrease at 3 min was only significant in comparison with the controls injected with inactivated hormone. Femoral blood flow and the venous minus arterial calcium gradients across the femur were positively correlated, irrespective of sampling time (0 or 30 min) or type of injection (PTH [Wilson] or carrier). Taken together, these results suggest that there is a relationship between calcium mobilization from bone and the rate of osseous blood flow. Other organs which showed significant changes in blood flow after PTH (Wilson) were the adrenals, thyroids, and shell gland; the cerebellum, parathyroids, heart, spleen, liver, pancreas, duodenum, magnum, isthmus, and kidneys were not affected.