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P E THOMPSON

Publications and source records attributed to P E THOMPSON.

At least 19 recordsLinked to original sources
PubMed1965

QUININE-RESISTANT PLASMODIUM BERGHEI IN MICE.

During induction of chloroquine resistance, Plasmodium berghei developed resistance to quinine administered in doses near the maximum amounts tolerated by mice. Resistant parasites did not form malarial pigment. Normal sensitivity to both quinine and chloroquine returned and pigment formation resumed during serial passage of the parasites through untreated mice.

Animals↗
PubMed1963

Dialysis studies in rats on the long-acting antimalarial CI-501.

Through the use of dialysis sacks, containing the repository antimalarial CI-501, implanted intraperitoneally into rats, evidence has been obtained indicating a local rather than a systemic reservoir of the drug. These results suggest that the repository activity of CI-501 is due to drug release from the injection site and that the probability of toxic effects resulting from storage or accumulation of the drug in vital organs is remote.

Animals↗