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Biomedical subjects

P El Baze

Publications and source records attributed to P El Baze.

9 recordsLinked to original sources
PubMed1985

Pseudomonas aeruginosa O-11 folliculitis. Development into ecthyma gangrenosum in immunosuppressed patients.

Six immunocompromised patients were shown to exhibit Pseudomonas aeruginosa folliculitis in apocrine regions similar to "swimming pool" folliculitis. The lesions evolved within 24 hours as severe ecthyma gangrenosum. The source of the P aeruginosa, serotype O-11, was found in the water system of the hospital. Clinical identification of the lesions and early treatment is important to prevent severe manifestations.

Adult↗
PubMed1984

Response of epidermal polyamines to orally administered aromatic retinoid RO 10-9359.

Polyamine levels were measured in skin (pure epidermis) and 24-h urine before and 15 days after the start of continuous oral treatment with Etretinate (1 mg/kg/day) in 20 patients with various dermatoses. In uninvolved epidermis, treatment modified levels of spermidine (45% increase, P less than 0.05) and spermine (30% increase, P less than 0.05). In urine, the putrescine concentration was significantly altered, increasing from 1.96 to 2.60 micrograms/mg creat (P less than 0.05). During the time interval considered, variations in polyamine levels did not reflect the inhibiting mechanism of retinoids on ornithine decarboxylase, the key enzyme in the regulation of polyamine synthesis.

Adult↗
PubMed1983

Polyamine levels in normal human skin. A comparative study of pure epidermis, pure dermis, and suction blister fluid.

The polyamines putrescine, spermidine, and spermine were detected and measured in both free and total forms in man in pure epidermis, pure dermis, suction blister fluid, blood, and 24-h urines. The technique employed for polyamine measurement consisted in liquid chromatography by ion exchange using an automatic amino acid analyzer and a fluorescence detection system. Polyamine concentrations were found to vary significantly between the dermis and the epidermis, both quantitatively and qualitatively: spermidine and spermine levels were much higher in the epidermis than in the dermis, and putrescine&spermidine and spermidine/spermine ratios were much lower in the epidermis. These differences reflect the known differences in cellularity, proliferative activity, and differentiation between these two cutaneous regions. The high spermidine and spermine concentrations in the epidermis suggest that these substances play a special role in this tissue.

Adult↗
PubMed1983

[Cutaneous neuroendocrine carcinoma : apropos of a case].

A case of neuroendocrine carcinoma (Merkel cell tumor) of the skin in a 76 years old woman is reported. The lesion, an erythematous nodule, 2 to 3 cm in diameter occurred on the face. Light microscopic examination showed sheets of indifferentiated cells that had a uniform round nucleus and scanty cytoplasm containing argyrophil granules. An ultrastructural study demonstrated neurosecretory type granules in the cytoplasm of the tumor cells. Immunocytochemical analysis was strongly positive for neuron specific enolase, but negative for Met-Enkephalin. This case is discussed in the light of a review of 73 cases already published in the literature. The origin of the cells involved in this tumor is still discussed. Several authors have suggested that this tumor is an Apudoma possibly arising from Merkel cells. In most cases, the lesion is an erythematous nodule. The most common localization is the face (45 p. 100). The tumor can be diagnosed by routine histology, but silver staining and electron microscopic study are often helpful. Removal of the tumor should be performed. This tumor appears to be of a low grade malignancy. Local recurrences or metastases have been reported in a few cases.

Adenocarcinoma↗