Biomedical subjects
Publications and source records attributed to P Elfving.
Double minute chromosomes were found in metaphases from short-term tissue cultures of two primary prostatic adenocarcinomas. This is the first cytogenetic evidence of gene amplification in this tumor type.
A squamous cell carcinoma was investigated cytogenetically by means of chromosome banding. The karyotype was complex with many structural and numerical changes, including -9 and del(11p), aberrations that also have been noted in transitional cell carcinoma. Thus, cytogenetic studies may be an important complement to the histological classification of bladder tumors, and may even contribute to our understanding of the etiology and pathogenesis of the 2 main types of bladder cancer.
Between 1980 and 1987, 54 patients with prostatic adenocarcinoma in stages T0 to T3, M0, underwent staging by pelvic lymphadenectomy, 16 with associated radical prostatectomy. Lymph node metastases were present in 28 cases (52%). In this study, the presence of pelvic lymph node metastases was better correlated to clinical stage than to histological grade.