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P Ericson

Publications and source records attributed to P Ericson.

4 recordsLinked to original sources

DNA adducts among personnel servicing and loading diesel vehicles.

The levels of aromatic DNA adducts were compared by the 32P-postlabeling assay between the lymphocytes isolated from bus maintenance and truck terminal workers, using hospital mechanics as a control group. The adduct levels were elevated in all the bus and truck terminal workers. Within the bus maintenance personnel, garage workers had the highest levels of adducts. Within the terminal workers those driving diesel forklifts had the highest adduct levels. The results suggest that diesel exhaust contributes to the level of adducts.

DNA↗

32P-postlabelling analysis of DNA adducts in humans: adduct distribution and method improvement.

32P-Postlabelling was applied to study the distribution of adducts in white blood cells of foundry workers exposed to polycylic aromatic hydrocarbons. The distribution of the adducts among 63 workers followed an apparently trimodal pattern, which could relate to polymorphism in PAH metabolism. A modified postlabelling method is described and some parameters were tested for optimal labelling. The total volume of the polynucleotide kinase reaction is 2 microliters, which decreases exposure to radioactivity and costs of isotopes.

Animals↗