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Biomedical subjects

P F Sheedy

Publications and source records attributed to P F Sheedy.

At least 109 records · Page 6Linked to original sources

Mediastinal parathyroid tumors: experience with 38 tumors requiring mediastinotomy for removal.

Most hyperfunctioning parathyroid tumors situated in the mediastinum can be removed by means of a cervical approach. However, a few tumors, because of their location deep in the chest, require mediastinotomy for removal. These tumors are probably derived from parathyroid glands that have developed from the third branchial pouch. Between 1942 and 1980, 38 such tumors were removed at the Mayo Clinic, using a sternum-splitting procedure. With one exception, the patients had undergone previous parathyroid exploration, Almost all of the patients had significant complications of primary hyperparathyroidism (HPT). Thirty-seven patients (97%) were cured after removal of their mediastinal parathyroid tumors, but postoperative chest complications were encountered in eight patients (21%), and eight have permanent hypoparathyroidism. Six patients had selective arteriography, two had selective thyroid venous sampling and parathyroid hormone assay, and 13 had mediastinal computed tomography in an attempt to localize tumors before operation. The anatomic locations of the tumors at operation were variable, but the vast majority (68%) were in or near the thymus.

Adenoma↗

Computed tomography and angiography of cavernous hemangiomas of the liver.

Cavernous hemangioma is the most common benign tumor of the liver. Eighteen patients were studied by both computed tomography (CT) and angiography. The angiographic features were classic, consisting of normal hepatic arteries, no tumor vessels, and densely stained blood-filled spaces producing a "cotton-wool" appearance. Before contrast infusion, CT scans showed roughly spherical, well-demarcated low-density masses; afterward there was a peripheral zone of enhancement which varied in thickness and sometimes had a corrugated inner margin, though the center remained low in density and the overall size of the lesion did not change. The authors feel that the CT findings are characteristic and that in some cases angiography is unnecessary.

Angiography↗

Computed tomography in duodenal rupture due to blunt abdominal trauma.

Computed tomography (CT) has become a useful procedure in the evaluation of abdominal trauma, since it is able to detect abnormalities in contour or tissue density of the major abdominal and retroperitoneal organs and spaces. Cases have been reported demonstrating the usefulness of CT in evaluating splenic, renal, and hepatic hematomas, retroperitoneal hemorrhage, spinal injuries, and traumatic diaphragmatic hernia. We describe a patient with traumatic rupture of the duodenum in whom CT played a key role in the diagnosis.

Adult↗

Orbital tumors evaluated by computed tomography.

Computed tomography (CT) of more than 90 orbital tumors revealed both benign and malignant neoplasms, including hemangiomas, lacrimal gland tumors, lymphomas, carcinomas, metastases, pseudotumors, and optic nerve tumors. Detection of orbital tumors was better and the information gained more complete with CT than with any other modality.

Adolescent↗

Computed tomography of the abdomen in evaluation of patients with fever of unknown origin.

Applying Petersdorf's classic criteria for fever of unknown origin (FUO), 75 of 6,654 CT scans were reviewed to evaluate the diagnostic effectiveness of abdominal CT. Twenty-three (29%) of these 78 scans had positive CT findings and 8 (10%) had positive but nonspecific findings. Abdominal exploration or biopsy was carried out in 20 of these 31 patients. In addition, 10 cases with negative CT results were explored. In no case was any gross anatomic abnormality found in these negative cases.

Abdomen↗

Campylobacter fetus ss. jejuni: a cause of massive lower gastrointestinal hemorrhage.

A patient is described with Campylobacter enteritis complicated by massive lower gastrointestinal bleeding from multiple mucosal ulcers in the terminal ileum and at the ileocecal valve. Repeated stool cultures and antibiotic therapy may be indicated in certain patients to diminish the morbidity arising from what may seem to be mild disease. In patients who suffer bleeding complications, arteriography before surgery is necessary to demonstrate an otherwise grossly indefinable source of bleeding.

Adult↗

Congenital absence of the portal vein.

A 4 1/2-year-old girl is described in whom the portal vein is absent and the venous return from the gastrointestinal tract, spleen, and pancreas is through the left renal vein into the inferior vena cava. She had a hepatoblastoma, which was treated surgically by right hepatic lobectomy. Regeneration occurred in the remaining left lobe within 3 months after surgery. This is the second such case documented in the literature.

Carcinoma, Hepatocellular↗

Roentgenographic findings in thoracic aortic dissection.

Review of 91 confirmed cases of thoracic aortic dissection revealed that the findings on the plain films of the chest often were suggestive of the diagnosis, with abnormalities in the aortic countour, especially when comparison was made with previous roentgenograms. The diagnosis was definitively made in 52 cases by retrograde transfemoral or transaxillary catheterization accomplished without complication. The most common angiographic findings were opacification of the false lumen, visualization of an intimal flap, and deformity of the true lumen. Early diagnosis and institution of appropriate therapy can improve survival in this disease.

Adult↗

Systemic artery-to-pulmonary vein fistula in osteogenic sarcoma of the chest wall.

An arteriovenous fistula between the systemic and pulmonary circulations may be congenital, as in bronchopulmonary sequestration, or the communication may be acquired. Inflammatory disease, trauma, and, rarely, neoplasm have been implicated as possible causes of acquired communications. We describe a patient who had a systemic artery-to-pulmonary vein fistula that was secondary to a recurrent sarcoma of the chest wall. Review of the literature failed to reveal a previous report of a similar case.

Adult↗

Computed tomography in the evaluation of subdural hematomas.

Computed tomographic (CT) scans used in the diagnosis and management of subdural hematomas were analyzed with respect to their contribution to angiography and surgery. There has been a progressive increase in the use of CT in evaluating post-traumatic and postoperative subdural hematomas at the Mayo Clinic. At present, 40% of all patients undergo operation on the basis of the CT findings alone. False-positive diagnoses revealed at surgery have decreased to less than 4%. Erroneous negative interpretations have involved 10% of all patients whose diagnosis was subdural hematoma. Criteria for the interpretation of scans have been established.

Brain↗