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Biomedical subjects

P F Wolf

Publications and source records attributed to P F Wolf.

5 recordsLinked to original sources
PubMed1987

Malignant salivary gland tumors of the base of the tongue.

We present a 41-year retrospective study of patients with malignant salivary gland tumors of the base of the tongue treated at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston. This report characterized the patient group, documents their physical findings, analyzes survival, and draws some conclusions regarding clinical course and treatment options. When feasible, surgical resection is the preferred treatment, with planned postoperative radiotherapy when indicated by pathologic findings.

Adenocarcinoma↗
PubMed1987

A predictive model for wound sepsis in oncologic surgery of the head and neck.

A prospective analysis of patients undergoing surgical resection of squamous cell carcinoma of the upper aerodigestive tract was performed in order to identify the patients at risk of postoperative wound infection and to develop a model predictive of wound infection. Fifty-nine patients who underwent extirpative clean-contaminated procedures--all of whom received cefazolin as the sole chemoprophylactic agent, were studied over a 1-year period. Twenty-three variables were recorded for each patient in the study. The overall rate of wound infection was 25.4%. Univariate analysis indicated that three variables were significantly related to the likelihood of postoperative wound infection. These included tumor stage (P = 0.0180), nodal stage (P = 0.0062), and duration of surgery (P = 0.0151). The Biomedical Computer Program (BMDP), a logistic regression program specifically designed for a binary dependent variable (infection vs. no infection) based on independent variables that may be continuous or categorical, was used in development of a model predictive of wound infection. T-stage, N-stage, and the presence of concomitant disease made up the combination of factors found to be most predictive of infection in our study population. Considering "success" to be the development of infection if the probability was 75% or higher, and the absence of infection if the probability was less than 25%, the multiple regression analysis model demonstrated a predictive success rate of 74.6%. Our results indicate that the risk of infection in patients undergoing clean-contaminated oncologic surgery of the head and neck is greatest for patients who have advanced disease that requires prolonged surgery in the presence of concomitant diseases.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

Melanoma metastatic to cervical and parotid nodes from an unknown primary site.

The medical records of 96 patients with melanoma metastatic to cervical and parotid nodes from an unknown primary site have been reviewed. The use of various surgical procedures were correlated with local recurrence and survival rates. The size and number of involved nodes and the extent of nodal disease were compared with the type of treatment, and the age and sex of the patients, incidence of above-clavicle recurrence, and the 2, 5, and 10 year survival rates. The only significant correlations were the adverse affects of patient age over 50 years and multiple, large, pathologically positive nodes on local control and survival. Adjunctive chemotherapy and immunotherapy had no therapeutic value.

Adolescent↗
PubMedDate not supplied

Rationale for elective modified neck dissection.

A retrospective study was conducted to give surgeons direction in deciding which type of modified neck dissection is proper elective treatment for the patient with a clinically negative neck. The medical records of 428 previously untreated patients (seen between January 1, 1970, and December 31, 1979) whose necks (i.e., NO) were electively dissected and who had had a primary squamous carcinoma of the oral cavity, oropharynx, larynx, or hypopharynx were included. The three major types of modified neck dissections studied were the supraomohyoid, the anterior, and the functional. Sixteen percent (70 of 428) of the patients had multiple positive nodes and 6% (28 of 428) had evidence of extracapsular invasion. A unilateral supraomohyoid dissection was most often used for primaries of the oral cavity. Bilateral anterior dissection was common for cancers of the larynx and hypopharynx, and functional neck dissection was equally distributed among the primary sites. None of the patients with primaries of the larynx or hypopharynx had pathologically positive nodes in the submental or submaxillary triangles. Advanced T-stage was generally associated with a greater incidence of subclinically positive nodes. Thirty percent of the patients received postoperative radiotherapy. The total number of nodes removed, the number of positive nodes with or without extracapsular invasion, and the anatomic location of the positive nodes were correlated with the type of dissection, the stage and site of the primary cancer, the use of postoperative radiotherapy, the regional (neck) failure, and survival.(ABSTRACT TRUNCATED AT 250 WORDS)

Carcinoma, Squamous Cell↗