Biomedical subjects

P Faarup

Publications and source records attributed to P Faarup.

At least 37 records · Page 2Linked to original sources

PubMed1979

Structural changes and ability to release renin in auto- and allo-transplants of mouse submaxillary glands.

In mice having a high renin content in the submaxillary glands allo- and autotransplantation of the gland showed identical histological changes of the tissue, comprising disappearance of acini and intercalated ducts as well as a reduction in the number and size of granules in the granulated ducts. No structural signs of rejection were found. Adenomas, possibly originating in the granulated ducts, were frequently present in the transplanted glands. The renin content of autotransplanted glands was invariably much higher than in allotransplants, and after noradrenaline injection renin was released only from autotransplants, never from allotransplants. Blockade of the renin system was accordingly followed by a decrease in blood pressure only in mice with autotransplants.

Animals↗

PubMed1978

Structural changes in kidneys of patients with oliguric extracapillary glomerulonephritis during immunosuppressive therapy.

Structural changes in kidney biopsies were investigated from five patients with primary oliguric extracapillary glomerulonephritis in whom the renal function was adequately maintained during extended combined immunosuppressive treatment. The most important structural change was a pronounced decrease in the number of crescents. Reduction in numbers of crescents in the late biopsies was significantly greater than the increase in the number of hyalinized glomeruli. Tubular parenchyma showed only slight diffuse atrophy, and a moderate interstitial fibrosis was always present during the latter stages of treatment. Disappearance of crescents in the glomeruli was not accompanied by disappearance of immunoglobulins. Successfull immunosuppressive treatment of extracapillary glomerulonephritis causes the disappearance of structural characteristics of the kidney that are diagnostic for this disease.

Adult↗

PubMed1978

Volume changes in the rat renal cortex during urography.

At different periods of urography rat kidney were instantly frozen at -165 degrees C. Using appropriate histological techniques and planimetry of different cortical compartments and fractions the structural background of renal cortical volume variations during urography was elucidated. The renal cortex reacted to intravenous injection of hypertonic contrast medium with an immediate increase of volume, followed by a decrease from 30 to 60 seconds. Measuring the volume shares of different cortical compartments, the complex nature of cortical volume variations during the first minutes of urography could be demonstrated. Subdivision of the tubular compartments into cellular and luminal fractions showed even greater complexity of volume variations. All the major cortical volume changes came to an end approximately three minutes after the injections.

Animals↗

PubMed1975

Fine structure of granulocytes with cytoplasmic inclusions in pleural effusions from patients with rheumatoid pleuritis, tuberculous pleuritis and pleural carcinomatosis.

The fine structure of neutrophil granulocytes from pleural fluid obtained from patients with rheumatoid or tuberculous pleuritis or epidermoid carcinoma of the lung was identical irrespective of the primary disease of these patients. Homogenously stained lipid-like inclusions were present in the cytoplasm of the neutrophil granulocytes. They seemed to be formed de novo, as they lacked a distinct limiting unit membrane. The fine structure of the lipid-like inclusions gave no evidence to support the presence of immune complexes, these were probably located in the quantitative much fewer phagosomes of the granulocytes.

Adult↗

PubMed1974