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Biomedical subjects

P Fayolle

Publications and source records attributed to P Fayolle.

13 recordsLinked to original sources
PubMed2006

Rectovaginal fistula following colectomy with an end-to-end anastomosis stapler for a colorectal adenocarcinoma.

An 11-year-old, female neutered Labrador retriever was presented with a micro-invasive differentiated papillar adenocarcinoma at the colorectal junction. A colorectal end-to-end anastomosis stapler device was used to perform resection and anastomosis using a transanal technique. A rectovaginal fistula was diagnosed two days later. An exploratory laparotomy was conducted and the fistula was identified and closed. Early dehiscence of the colon was also suspected and another colorectal anastomosis was performed using a manual technique. Comparison to a conventional manual technique of intestinal surgery showed that the use of an automatic staple device was quicker and easier. To the authors' knowledge, this is the first report of a rectovaginal fistula occurring after end-to-end anastomosis stapler colorectal resection-anastomosis in the dog. To minimise the risk of this potential complication associated with the limited surgical visibility, adequate tissue retraction and inspection of the anastomosis site are essential.

Adenocarcinoma↗
PubMed1997

Experimental bilateral lobar lung transplantation and its application in humans.

BACKGROUND: The critical lack of donor organs from people of small size or children has created great difficulties in transplantation for recipients who are of smaller size. Surgical techniques of organ reduction and partial transplantation may to some extent solve the problem of disparity in organ size, be it liver or lung, and lessen the problem of scarcity of paediatric organs. METHODS: In a series of experiments on dogs the surgical technique of pulmonary partition of a large organ from a grown dog followed by transplantation of lobes, either unilaterally or bilaterally, into a young dog was studied. Two series of experiments were performed in two groups of animals; in group 1 transplantation of a single right lobe (n = 6) or single left lobe (n = 6) from a split adult lung was carried out and in group 2 (n = 10) animals received bilateral lobar transplants from a single split adult lung. The animals were sacrificed at fixed intervals (days 8-120 in group 1, days 7-10 in group 2) and the results of the surgical technique were assessed. RESULTS: Healing of lobar bronchial anastomoses was found to be excellent with no histological evidence of dehiscence or ulceration. There was one bronchial anastomotic stenosis and one arterial thrombosis. Morphological and functional adaptation of the lobes in the thorax was found to be excellent in both groups of animals. The technique has been applied in a clinical setting and the first patient with bilateral lobar lung transplantation followed for 30 months is reported. CONCLUSION: Lung partition and subsequent lobar transplantation, either unilaterally or bilaterally, is associated with satisfactory early results in an animal experimental model. Initial clinical experience in one patient has been successful.

Adult↗
PubMed1990

Distribution of material injected intramuscularly in dogs.

A radiopaque marker was injected, using needles of various lengths, into the cervical musculature, the lumbar epaxial musculature, and the cranial and caudal muscular masses of the thighs of anesthetized dogs. After this procedure, the dogs were euthanatized and deep-frozen. The bodies were then sectioned, and the slices were radiographed to determine the fate of the injected material. Material that was injected into the neck or caudal region of the thigh was determined to be located in the muscle bellies or dispensed throughout the intermuscular fascial sheaths. In contrast, material injected into the lumbar area and cranial region of the thigh was located entirely in the muscle bellies. It was concluded that the best sites for injection in dogs are the lumbar epaxial musculature or the quadriceps femoris muscle when IM administration is imperative.

Animals↗
PubMed1987

Routine hematology and clinical chemistry in female dogs with benign and malignant mammary tumors.

Routine hematological and serum biochemical screening was done in 61 female dogs with benign mammary tumors and 51 female dogs with malignant mammary tumors. Most parameters were not significantly different from age-matched female controls; moreover, no significant difference could be observed between animals with benign and malignant tumors. It is concluded that routine hematology and biochemistry offer little diagnostic or prognostic benefit in female dogs with mammary tumors.

Journal Article↗
PubMed1986

Bovine plasma and synovial fluid kinetics of methylprednisolone and methylprednisolone acetate after intra-articular administration of methylprednisolone acetate.

After an intra-articular administration of methylprednisolone acetate (MPA) in the cow, methylprednisolone (MP) was detected in the synovial fluid, at pharmacologically significant concentrations, during more than 3 months. From in vitro assay, it was shown that hydrolysis of MPA to MP was rapid both in blood (half-times from 11.8 to 21.7 min) and in synovial fluid (half-times from 45.6 to 130.3 min). After intra-articular administration of MPA as a suspension (200 mg in toto), both MP and MPA decline very rapidly and, 24 hr after injection, less than 1% of the dose was present in the synovial fluid, but systemic availability of MP during the first 24 hr was only 30% of the dose. Twenty-four hours postadministration, post-mortem examinations showed a significant quantity of MPA precipitated at the bottom of the synovial cavity. It was assumed that the relatively slow decline of MP synovial fluid concentration from 24 hr to 5 days postadministration was due mainly to a process of MP absorption. After this delay, the synovial fluid concentration decreased very slowly with an apparent half-time of 18 days. This has been tentatively explained in terms of a slow release of MP from MPA embedded in a fibrin-like deposit. Despite the fact that the quantity of MP absorbed each day was small, long-term systemic effects were observed. During 6 weeks, plasma hydrocortisone levels remained low or undetectable and the return to normal adrenal responsiveness to an adrenocorticotropic hormone test took 12 weeks.

Adrenal Glands↗
PubMedDate not supplied

[Red cell indices in the aged. 1 726 patients over the age of 70 (author's transl)].

Statistical analysis of red cell constants in 1 726 patients over the age of 70 shows that red cell counts, hemoglobin and hematocrits are slightly lower than those in young adults. However, the quality of the red cells is normal, because the MCV (mean cell volume) and MCHC (mean cell hemoglobin concentration) are normal.

Aged↗
PubMedDate not supplied

[Frequency and etiology of anemia in patients over the age of 70 (author's transl)].

The study of 1 726 patients living in homes for the aged, or hospitalized shows that 20% of them have anemia. There is no increase in prevalence of the disease in females. A wide variety of mechanisms may cause anemia. However, chronic bleeding of essentially digestive origin is the most common. Several anemia-causing factors are particularly frequent in the aged: bleeding, inflammation, nutritional deficiencies, bone marrow failure. Diagnosis is complicated and may require examinations which are not always easily accepted by the aged.

Aged↗
PubMedDate not supplied

Exaggerated femoral anteversion and acetabular development: experimental study in growing dogs.

Femoral excessive anteversion caused by femoral osteotomy in growing dogs is an accurate dynamic model of experimental acetabular dysplasia. Radiographic and CT scan examinations were performed throughout the growing period. Evolution showed an incomplete femoral detorsion. It induced acetabular developmental modification leading to an anterior and superior acetabular dysplasia. At the end of the growing period, hips were not dislocated, but signs of femoral and acetabular osteoarthritis were obvious, which shows the importance of mechanical force modification in the creation of experimental osteoarthritis. The links between hip osteoarthritis and exaggerated femoral anteversion are discussed. Might acetabular dysplasia be secondary to femoral anteversion, which could justify a corrective osteotomy during childhood? Our experiment leads to a better comprehension of this phenomenon.

Acetabulum↗
PubMedDate not supplied

[Experimental model of pulmonary bipartition with bilateral lobe transplantation in dogs and application to clinical medicine].

The crucial need for donors of paediatric or small sized organs has been a great obstacle to overcome in organ transplantation in children or small adults. Some progress in adapting size of the donor organs has been achieved with surgical procedures for reducing the size of donor organs, partial transplantation (single lobe of the liver or the lung) and liver partition, offering a partial solution to the insufficient supply of paediatric organs. We propose an experimental model in the dog of lung partition associated with monolateral (series I) or bilateral (series II) lobe transplantation. The results have been encouraging both in terms of quality of healing and in morphological and functional adaptation of the transplanted lobes, allowing us to apply this technique of lung partition and bilateral lobe transplantation in human patients. The outcome has been excellent in the first case after 18 months follow-up.

Animals↗