Biomedical subjects
Publications and source records attributed to P Ferrer.
Attention has previously been drawn to a specific effect of NHCP on embryonic Pleurodeles cell differentiation. With a modified NHCP labelling technique, autoradiography has revealed a cytoplasmic concentration of labelled NHCP and has not revealed any difference between homospecific and heterospecific NHCP penetration.
Nuclear non-histone (NNH) proteins, both chromatin-associated and otherwise, have been prepared in defined conditions, either from nuclei or from washed chromatin. When these NNH proteins are homospecific, they produce inhibitory effects on morphological differentiation of embryonic Urodelan Amphibian cells cultivated in vitro. When they are heterospecific, on the contrary, they have no action on the differentiation of those cells. It is concluded that the effects of the non-histone proteins on cell differentiation depend upon the relationship between the animal species which is used to provide the proteins and that used to provide the reactive material.
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OBJECTIVE: To assess the quality of filling medication trolleys process for an unit-dose drug distribution system, after the implantation of a protocol. METHOD: Five criteria were defined: four were related to the medication given to the patient, and one criterion was related to the patient's identification. At the same time, it was designed a standardized protocol of filling medication trolleys process and it was evaluated the degree of compliance with the criteria on all the hospitalized patients medication drawers in two clinical units. The fulfilment of the criteria was measured both before and after the implantation of the protocol, for fourteen and seven days respectively. RESULTS: In the first evaluation the number of errors was 0.84/medication drawer. After the implantation of the protocol, the total number of errors after correction for sample size decreased at 0.22/medication drawer. The degree of compliance improved for all the criteria, and differences were statistically significant for the criteria with most errors. CONCLUSIONS: The implantation of a protocol significantly improved two of the five quality criteria studied in the filling medication trolleys process. The patient's identification has been revealed as a fundamental aspect of intervention in the dispensation quality.
In this article, we consider the impact on downstream process design resulting from the use of metabolically engineered yeast strains. We address the issue of how manipulation of cell wall permeability can improve the release and subsequent recovery of heterologous products produced in yeast.
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