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Biomedical subjects

P Flor-Henry

Publications and source records attributed to P Flor-Henry.

13 recordsLinked to original sources
PubMed1991

Quantitative EEG studies of pedophilia.

Ninety six pedophiles, whose sexual orientation was confirmed by phallometric response to sexual stimuli, were investigated with quantitative EEG and compared to age- and sex-matched healthy controls. The EEG analysis showed a pattern of increased frontal delta, theta and alpha power (especially during verbal processing) and a pattern of reduced interhemispheric and increased intrahemispheric-interhemispheric coherence, right and left (only during verbal processing), an effect that was restricted to those who showed maximal erotic arousal for sexual partners aged 6-12 years. These findings will be discussed in the context of recent studies which suggest that sexual deviations in the male relate to altered dominant hemispheric functions with disruption of frontal interhemispheric relationships.

Brain↗
PubMed1990

Neuropsychology and psychopathology: a progress report.

This paper summarizes and discusses the contributions of neuropsychological assessment to various forms of psychopathology. Emphasis is placed upon studies done with the Halstead-Reitan battery and the Wechsler Adult Intelligence Scale, but studies done with other neuropsychological test procedures are also reviewed. The conclusions reached are that neuropsychological tests are sensitive to functional regional brain disorganization in psychopathology, and that they are useful in the diagnostic process for a number of disorders including schizophrenia, psychopathy, mood disorders, and other psychiatric conditions.

Affective Disorders, Psychotic↗
PubMed1990

Neurophysiological and neuropsychological study of two cases of multiple personality syndrome and comparison with chronic hysteria.

Two cases of multiple personality were studied neurophysiologically and neuropsychologically. Bilateral frontal (Right greater than Left) and left temporal dysfunction was present in both cases, on neuropsychological indicators. Both cases on EEG analysis, were in a state of relative left hemisphere activation, across all cerebral regions and task conditions. The one case who was cured with hypnotherapy, after recovery showed normal left hemisphere functions neuropsychologically but remained in a state of relative left hemisphere activation electrophysiologically. This is in contrast to women with chronic hysteria who exhibit relative right hemisphere activation in all regions and across all conditions. Both patients were unmedicated throughout. A neurophysiological model to account for these findings is presented.

Adult↗
PubMed1990

Influence of gender in schizophrenia as related to other psychopathological syndromes.

The evidence indicating that the forms of schizophrenia in men and women represent different morbid states is reviewed. Age of onset and gender are considered to be of fundamental importance in determining the different symptomatological and evolutionary features of the syndrome in the two sexes. Early-onset forms in males are associated with chronicity, absence of familial predisposition for psychosis, and the presence of structural cerebral pathology specifically involving the dominant hemisphere. Later onset forms in females are characterized by more florid symptoms, more affective features, more familial psychosis, and more favorable outcome with no or less pronounced structural cerebral involvement. It is argued that these differential characteristics derive from the differential hemispheric organization of the male and female brain--which also determines the male susceptibility to other psychopathological syndromes such as psychopathy and sexual deviations as well as the excess in women of schizoaffective states, affective disorders, and late-onset schizophrenia.

Brain↗
PubMed1989

Neuroleptics reverse attention asymmetries in schizophrenic patients.

Discussions of hemispheric asymmetry in psychopathology are often confounded by the effects of medication. We examined the effect of neuroleptic drugs on attention asymmetries in acutely psychotic patients admitted for the first time to a psychiatric hospital before the initiation of drug treatment and again after a period of treatment with neuroleptics. Overall performance did not change significantly; however, attention asymmetry was clearly related to the medication status of the patient: unmedicated patients showed inattention to the right hemispace, which changed to more prominent left-sided inattention when medicated. A longer time on medication or a higher daily dose were associated with a shift of inattention from the right to left hemispace. This suggests that neuroleptics may normalize left hemisphere performance, at the expense of deteriorated right hemisphere performance.

Adult↗
PubMed1979

Neuropsychological and power spectral EEG investigations of the obsessive-compulsive syndrome.

Eleven consecutive patients with primary obsessive-compulsive syndrome were studied neuropsychologically and the power spectral EEG characteristic of ten of these patients unmedicated, at rest, and during cognitive tasks were analyzed. The finding of predominantly left frontal dysfunction in the obsessional syndrome is discussed in the light of neurophysiological and psychosurgical evidence which suggest that perturbation of the cingulate-orbital frontal connections modulates obsessive-compulsive symptomatology.

Adult↗
PubMedDate not supplied

[The obsessive-compulsive syndrome: reflection of fronto-caudate dysregulation of the left hemisphere?].

Neuropsychological studies of the obsessional syndrome reveal bilateral frontal dysfunction. Early onset is characteristic of males, who have a more chronic course than females, and who are more often non-dextral. Hypermetabolic activity of the frontal and caudate, bilaterally, is found in most PET investigations, although one report is of relative hypofrontality and global cortical hypometabolism for absolute values. Given the frequency with which basal ganglia disease leads to obsessive-compulsive phenomena (Cf Sydenham's Chorea, Gilles de La Tourette) and frontal lobe inertia, a perturbation of frontal-caudate regulatory motor and ideational sub-systems in the obsessional syndrome appears probable. Bilateral caudate atrophy on CT scan has been reported. Further, EP investigations, both somatosensory and auditory, implicate the left hemisphere in obsessions; together with reduced P300 latencies and during imaginal flooding there is increased left (frontal) hemisphere flow (rCBF). Single case studies document the relationship of obsessions to left frontal-left caudate unilateral pathology. It is suggested that lateralized dysregulation of the left fronto-caudate network is the major cerebral determinant of obsessive-compulsive states.

Brain Diseases↗