Biomedical subjects

P Foresta

Publications and source records attributed to P Foresta.

24 records · Page 2Linked to original sources

PubMed1979

Synthesis of 7-acylamidodesacetoxycephalosporanic acids and corresponding pivaloyloxymethyl esters. Chemical and microbiological properties.

A series of 7-acylamidodesacetoxycephalosporanic acids and analogous pivaloyloxymethyl esters have been prepared and tested in vitro for antibacterial activity. Those acids which exhibited a significant in vitro activity, were also studied in vivo and compared with the corresponding esters. Experiments performed on laboratory animals showed that, after oral administration, the esters were absorbed more efficiently than the corresponding acids.

Animals↗

PubMed1977

A new cephalosporin derivative (ST-21) orally administered in laboratory animals.

The pivaloxymethyl ester of 7-(D-2-amino-2-phenylacetamido)-desacetoxicephalosporanic acid hydrochloride (ST-21) and cephalexin possess the same bacteridal activity. In fact, in the animal body ST-21 releases cephalexin. The acute toxicity study shows the good tolerance of both substances, whereas the tissue distribution is different, both after oral and i.v. administration. Cephalexin concentrations in some tissues of rats and rabbits, particularly in the lungs and kidneys, are higher and longer-lasting in the animals treated with ST-21 than in those receiving cephalexin, thus showing a different pattern of distribution in the body. For this reason ST-21 might be more suited for the treatment of lung and kidney infections.

Administration, Oral↗

PubMed1973