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Biomedical subjects

P Fornara

Publications and source records attributed to P Fornara.

At least 19 recordsLinked to original sources

Clinical evidence of systemic persistence of bacillus Calmette-Guerin: long-term pulmonary bacillus Calmette-Guerin infection after intravesical therapy for bladder cancer and subsequent cystectomy.

A patient with urothelial bladder carcinoma is reported who suffered from culture proved pulmonary bacillus Calmette-Guerin (BCG) infection 14 months after a single course of intravesical BCG and 11 months after subsequent radical cystectomy for progressive cancer. This unusual case raises the question of the ultimate fate of intravesically instilled BCG and the possible persistence of these mycobacteria in remote organs. Systemic spread and dormant survival at least in some cases are suggested, and therapeutic and diagnostic consequences are discussed.

Administration, Intravesical

[The current status and place of open surgery in treating urolithiasis].

Within the concept of treatment of urinary calculosis, open surgery still occupies a firm place. At present, however, the indications for open surgical interventions have been considerably narrowed, and only a small group of patients with urinary calculosis are subject of open surgery, which requires experienced operators and special instruments for optimally sparing performance of the operation. Often intraoperative echography makes useless the application of intraoperative hypothermia and intraoperative X-ray diagnosis.

Endoscopy

[Clinical relevance of radioimmunologic determination of prostate specific antigen in prostate cancer].

To recognize progression of an inoperable prostatic cancer we use clinical parameters and the prostate specific phosphatase. The prostate specific antigen (PSA) is a new, sensitive and specific laboratory tumor marker. With 363 specimens of patients without prostatic cancer we defined for the normal range of this serum parameter. In 98 men with histologically proven prostatic cancers we investigated for the clinical relevancy of the serum level of PSA. We believe, that measurement of serum PSA give important information for clinical management of prostatic cancer.

Acid Phosphatase

[Value of percutaneous diagnosis and therapeutic procedures in obstructive uropathy following kidney transplantation].

Postrenal obstruction is a severe complication after renal transplant. To evaluate side effects and effectiveness we analyzed 71 ategrade pyeloureterographies (AP) and 30 percutaneous and open nephropyelostomies. AP shows a sensitivity of 93% and proved thereby its superiority to alternative diagnostic procedures. Also percutaneous pyelostomy proved its reliability in therapy of obstructive disease. Comparing side effects to those in normal kidneys we found a higher incidence of bleeding (17%). There was no severe complication with loss of graft. In 6 cases of obstructive disease we could prevent an operation by temporary percutaneous nephrostomy. Long term nephrostomy allows to evaluate the function of the kidney accurately which may not be possible until after 1-2 months.

Diagnosis, Differential

[Update in transplant surgery with special reference to the problem of organ donation].

The authors analyze the advances made and the current state of the art in transplant medicine and surgery, dealing at some length with the problems relating to organ donation. Particular attention is devoted to the provisions of law currently applicable in this field and those aspects currently under debate, comparing the situation in Italy with that obtaining elsewhere in Europe. The authors also focus on the need to make medical practitioners fully aware of the problem so as to achieve practical collaboration of the type possible today in West Germany.

Brain Death