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Biomedical subjects

P Frühmorgen

Publications and source records attributed to P Frühmorgen.

At least 19 recordsLinked to original sources
PubMed1992

[Cavernous liver hemangioma with arterio-portal fistula].

Evidence of a cavernous hemangioma of the liver with fistula between hepatic artery and the portal vein of a 52 year-old woman with colickly upper abdominal pain and ascites was obtained using Duplex-Doppler-ultrasound. The diagnosis was confirmed by selective arteriography. After ligation of the left hepatic artery clinical symptoms abated. The cavernous hemangioma was followed up over 7 1/2 years with ultrasound. Ultrasound has been shown to be a valuable test for diagnosis and follow up of cavernous hemangioma.

Angiography↗
PubMed1991

[Tube dislocation following percutaneous, endoscopically-controlled gastrostomy--a case report].

Percutaneous endoscopic gastrostomy (PEG) is an accepted and increasingly utilized means of obtaining access to the gastrointestinal tract for alimentation. The Memosond (Pfrimmer-Viggo Co.) as a new system presents advantages in comparison to the commonly used thread-guided tubes rendering a simplified technique of setting the tube and giving the possibility of later changing without repeated endoscopy. We present a case of a 65 yr female patient with advanced carcinoma of throat. A PEG using a Memosond system was performed. Two days later the distal part of the tube dislocated into the abdominal cavity. The patient died four days later of her malignant disease.

Aged↗
PubMed1990

Risk and surveillance of individuals with colorectal polyps. Who Collaborating Centre for the Prevention of Colorectal Cancer.

Since colorectal adenomas are very probably the precursors of colorectal cancer, their detection and removal should result in a decrease in the incidence and mortality from colorectal cancer. Individuals who harbour an adenoma have a 30-50% probability of having additional adenomas at that time, and a 30% probability of having additional adenomas later. Adenomas are prevalent in countries where colorectal cancer is prevalent, about two-thirds of them being tubular and the rest tubulovillous or villous. The initial management of patients with an adenoma consists in searching by colonoscopy the entire colon and removing all additional polyps. Surgical resection is required wherever there is invasive cancer with adverse histological factors. Follow-up in most patients can be after 2-4 years, earlier follow-up being reserved for patients with numerous polyps or with a polyp that had been removed piecemeal. The results of ongoing trials should provide firm guidelines for follow-up and could also be used in mathematical modelling to examine alternative strategies and to help understand the evolving patterns of appearance of new polyps. Finally, a deeper understanding of the biology and inherited and acquired genetics will help identify individuals at risk for adenomas initially and at follow-up. Nutritional factors may also provide a basis for prevention of adenomas in high-risk countries. Many of these issues are being addressed in current research.

Adenoma↗
PubMed1990

[Detection of antibodies to Helicobacter pylori with the immunoenzyme test and indirect immunofluorescence].

Sera from 56 adult patients were screened for the presence of IgG antibodies against Helicobacter pylori by enzyme immunoassay and indirect immunofluorescence. In addition, the detection of Helicobacter pylori in antral biopsy specimens was attempted by culture and histological methods. Colonisation of the antrum mucosa with Helicobacter pylori was observed in 39 of the 56 patients. IgG antibodies against Helicobacter pylori were detected by enzyme immunoassay in 34 of 39 infected patients. Thus, the enzyme immunoassay showed a sensitivity of 87.2 percent and a specificity of 82.4 percent. IgG antibodies against Helicobacter pylori were further detected by indirect immunofluorescence in 28 of 39 infected patients. Thus, indirect immunofluorescence showed a sensitivity of 66.7 percent and a specificity of 88.2 percent. Our results demonstrate that the enzyme immunoassay for IgG antibodies and other invasive or noninvasive methods for the detection of infection with Helicobacter pylori appear to be of equal sensitivity and specificity.

Adult↗
PubMed1990

[Complications in 39,397 endoscopic studies--a 7-year prospective documentation on method and incidence].

All complications of diagnostic and therapeutic endoscopic procedures from Feb. 1, 1982, to Jan. 31, 1989, at the Medical Department I of the Ludwigsburg hospital were reviewed. Complications occurred in 0.02% of all esophago-gastroduodenoscopies, in 0.09% of all endoscopic retrograde cholangio-pancreaticographies and in 0.05% of all colonoscopies. Rectos-copies and laparoscopies have to date been performed without complications. For therapeutic endoscopic procedures, the incidence of complications varies depending on the type of procedure performed. In 1.2% of gastric polypectomies, in 0.52% of colonic polypectomies and in 2.22% after endoscopic papillotomy complications occurred. In summary, both diagnostic and therapeutic endoscopy with adequate training can be considered as very safe procedures and only rarely leading to complications or death.

Endoscopy↗
PubMed1988

[ Aneurysma spurium of the pancreaticoduodenal artery].

A predominantly cystic process of the upper abdominal region of a 61 year old female patient was punctured via the fine-needle technique. The clinical assumption had been a lymphoma. Bright red blood was aspirated. The Doppler sonographic measurement revealed an arterial pulsating aneurysmatic process, and this was subsequently proved by selective angiography and, finally, by surgical treatment.

Aneurysm↗
PubMed1988

[Endosonographic tumor staging of gastrointestinal tumors].

In 24 surgical specimens of gastrointestinal tumours the extent of the tumour (T-classification) and the degree of involved lymph nodes (N-classification) were examined. In a preceding study including a subgroup of the cases the high degree of comparability between preoperative endosonography and endosonographic examination of the surgical specimen was demonstrated. The T-classification matched in 75%, an incorrect classification was found in 20%. In 5% the identification of the different layers of the wall was impossible. N-classification was very difficult because of the small amount of identified lymph nodes (25%) and the insufficient sonographic criteria of dignity.

Adult↗
PubMed1988

[Ultrasound controlled fine needle cytology and fine needle histology in circumscribed pancreatic processes].

Using a biopsy transducer 171 fine-needle punctures of focal pancreatic processes were done in 158 patients. The final diagnosis was made in the first group by surgical operation or autopsy, in the second by the further clinical course. The sensitivity of the cytological examination alone was 78% in the first group and 90% in the second. The histological examination alone had a sensitivity of 79% to 100%. Combining both ways of examination according to defined criteria the sensitivity in the first group was 84% and in the second 100%. The specificity was 100% for both. The complications were 2.9%. Of these 5 cases one pancreatitis had to be operated. There were no lethal complications. To optimize the sensitivity and specificity of the ultrasound guided fine needle puncture technique we want to recommend the following points: A biopsy transducer or puncture-aid must be available. The fine needle technique only should be done under the prerequisite of a high frequency of punctures and a high constancy in the relation between puncturer and pathologist. To receive representative material it can be necessary to make several needle passes during one session. Material for cytological und histological examination should always be taken simultaneously.

Adult↗
PubMed1985

[Successful acute treatment of chronic inflammatory intestinal diseases with oral 5-aminosalicylic acid].

The effectiveness of oral 5-aminosalicylic acid (0.5 g t.i.d.) and of salazosulfapyridine (1.0 g t.i.d.) was compared in a randomized controlled study in two groups with 30 patients each with ulcerative colitis and with Crohn's disease. Persistent complaints within the first 5 days were treated with additional methyl-prednisolone (40 mg/d initially). After treatment for 8 weeks patients with ulcerative colitis showed morphologic remissions in 60% of the 5-aminosalicylic acid group and in 53% of the salazosulfapyridine group. Clinical improvement was achieved in 86% in both groups. Clinical improvement in Crohn's disease was seen in 87% of patients of the 5-aminosalicylic acid group and in 80% of the salazosulfapyridine group. This was evidenced by the significant fall (P = 0,0001) of the mean activity index. Additional steroid medication was nearly equal in both treatment groups. There were no side effects during treatment with 5-aminosalicylic acid. In contrast, salazosulfapyridine had to be withdrawn in four patients due to signs of intolerance. 5-Aminosalicylic acid can thus be considered a valuable alternative to conventional treatment on the basis of equal effectiveness as salazosulfapyridine and lack of undesirable side effects.

Adolescent↗
PubMed1979

[Developments in the diagnosis of colorectal carcinoma. Comparison of various diagnostic groups].

Epidemiological observations on colorectal cancer and the consequences of modern diagnostic methods are reported on patients treated in the Medical and Surgical Hospital of the University of Erlangen during the past 9 years. In this period the distribution of the rectal carcinomas according to the Dukes-classification was constant. Using coloscopy consequently as routine method and by proving occult intestinal bleeding as screening method, we succeeded in diagnosing colorectal carcinomas in an earlier stage of Dukes' classification.

Colonic Neoplasms↗
PubMed1979

Complications of diagnostic and therapeutic colonoscopy in the Federal Republic of Germany. Results of an inquiry.

In April, 1978, we carried out a survey covering 27 hospitals, in which colonoscopy is performed on a routine basis. With respect to the size of the hospital, the equipment available and the level of training of the examiner, this selection may be regarded as representative. A total of 35,892 colonoscopies, 7,365 polypectomies, 58 electrocoagulations and 14 rugectomies were analysed with respect to the nature, localization and treatment of any complications that arose. The rate of complications seen in diagnostic colonoscopy was 0.008% for bleeding and 0.14% for perforation, the mortality rate being 0.02%. As expected, the complication rate for colonoscopic polypectomy was higher. Bleedings were reported in 2.24%, perforations in 0.34% and deaths in 0.1% of the examinations. Of particular importance would seem to be the possibilities of preventing complications. It was shown on the basis of the survey that a good, standardized training of the endoscopist, the strict observance of the contraindications, the non-use of analgesics and general anaesthesia, fluoroscopic control of "difficult" colons and the use of the best instruments and aids presently available, reduce the complication rate to a minimum.

Colon↗