PubMed Health⌕ Search

Biomedical subjects

P Fragola

Publications and source records attributed to P Fragola.

6 recordsLinked to original sources
PubMed1988

Effects of left bundle branch block on left ventricular function in apparently normal subjects. Study by equilibrium radionuclide angiocardiography at rest.

To determine the independent effects of left bundle branch block (LBBB) on global and regional left ventricular (LV) function we performed equilibrium radionuclide angiocardiography at rest in 3 patients with chronic LBBB (group I, mean age 53.6 years and in 6 patients with intermittent LBBB (group II, mean age 41.5 years). All patients were judged to have an apparently normal heart. In 2 of 3 patients of group I a LV ejection fraction lower than 50% was observed, and in all 3 patients septal motion abnormalities were present. In all patients of group II the global LV ejection fraction was normal during normal conduction and decreased during LBBB; the inferoapical regional ejection fraction decreased in 5 of 6 cases and the posterolateral regional ejection fraction in 3 of 6 cases. Moreover, septal hypokinesis was observed both during normal and abnormal conduction in all group II patients. These findings seem to confirm that LBBB, chronic or intermittent, is able to deteriorate LV performance at rest, even in patients with an otherwise normal heart.

Adult↗
PubMed1981

[On the genesis of the first heart sound: phono-echocardiographic study in patients with A-V block (author's transl)].

A phono-echocardiographic study of acustic and morphologic events was performed in three patients with atrioventricular block in order to assess the role of the mitral valve in the changes of the amplitude of the first heart and, more generally, in the genesis of the first heart sound. Simultaneous recording of the electrocardiogram, the apical phonocardiogram and the mitral echocardiogram showed: 1) the coincidence between the C point of the echocardiogram and the onset of the earlier high frequency vibrations of the first heart sound (M1); 2) a close correlation between the intensity of the first heart sound and the position of the mitral valve at the onset of ventricular systole (P less than 0.001); 3) longer duration of the first heart sound in those beats when there was superimposition of P wave in QRS. The authors illustrate the recent reports about the genesis of the first heart sound and emphasize the main role of the mitral valve suggesting that the position of the mitral leaflets at the onset of ventricular systole influences the mechanism of acceleration and deceleration of blood and vibrations of the "cardiohemic system".

Adult↗