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Biomedical subjects

P Frisch

Publications and source records attributed to P Frisch.

16 recordsLinked to original sources

The use of preoperative intra-aortic balloon pump in open heart surgery.

AIM: Intra-aortic balloon pump (IABP) therapy before open heart surgery has been suggested for ''high risk'' patients. METHODS: Records from patients undergoing open heart surgery at our institution between June 1999 and February 2002 were reviewed. Indication for IABP insertion was severely impaired left ventricular function, acute myocardial infarction (MI) or unstable angina. RESULTS: Fifty-five patients were included in the study: 41 male, 14 female, age 64+/-9 years. Fifty-one (92.7%) required coronary artery bypass brafting (CABG) alone or as a combined procedure, 2 (3.6%) required mitral valve surgery, and 2 (3.6%) needed more complex cardiac procedures. Thirty-two patients (58%) underwent emergency cardiac surgery and 11 patients (20%) suffered from acute preoperative MI. The overall 30 days mortality was 9%. Mean intensive care unit (ICU) stay was 6+/-8 days. Four patients (7.2%) developed postoperative renal failure requiring temporary hemodialysis. Three patients (5.4%) developed IABP related peripheral vascular complications. CONCLUSIONS: Perioperative morbidity and mortality is increased despite preoperative IABP, particularly in patients with acute MI. In contrast to studies not using this approach, preoperative IABP reduces morbidity and mortality of high risk patients. IABP related complications are low. Our data suggest that high risk patients profit from preoperative IABP therapy, however, prospective studies are needed to confirm these findings.

Cardiac Surgical Procedures↗

[The effects of atenolol on the heart size, on the heart rate, and on the blood pressure at rest (author's transl)].

Cardiac functions like heart size, heart rate, and blood pressure were studied at rest in 23 digitalized and 24 not digitalized patinents recovering from a myocardial infarction, in 16 patients with arterial hypertension and in 9 patients with regulatory dysfunctions of the circulation before and after a three week period of treatment with 2 x 50 mg or 2 x 100 mg atenolol per day. The heart rate and the blood pressure of every patient were significantly reduced, whereas the heart size which was determined by X-ray in lying patient showed no clear difference. Furthermore, the determination of the heart size facilitates the decision of the additional digitalization when the start of a long-term treatment with beta-blocking agents seems to be necessary in the aforementioned patient groups.

Atenolol↗

[The influence of doxepin on the efficiancy of the human heart (author's transl)].

This work was aimed at clarifying whether the anti-depressant doxepin had a cardiodepressant action, or favoured or initiated arrhythmias and/or ventricular conduction disorders, when administered orally for 14 days at a daily dosage of 75 mg. Under doxepin therapy there was a slight increase in mean heart rate on effort in comparison to the placebo. This increase, which amounted to 2 to 6 beats per minute, was most marked among the younger patients, but had neither clinical nor statistical significance (cocaine-like effect of tricyclic psychotropic drugs). No significant changes of ECG, blood-pressure, x-ray determination of heart volume (by the method of Klepzig and Frisch), and maximum performance on the cycle ergometer were stated under doxepin therapy in comparison to the placebo. On the basis of these results it appears justified to state that administering oral doses of about 75 mg doxepin per day for moderately long periods produces no cardiotoxic side-effects.

Age Factors↗