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Biomedical subjects

P Fuller

Publications and source records attributed to P Fuller.

10 recordsLinked to original sources
PubMed1995

Hepatocyte growth factor gene expression after massive small bowel resection: lack of stimulation in lung and liver.

Both hepatic and renal regeneration are associated with rapid increases in hepatocyte growth factor (HGF)mRNA levels, not only in the regenerating tissue, but also in the lung. In this study, changes in the levels of HGF mRNA in the terminal ileum and also in distal organs in the rat following massive small bowel resection (MSBR) have been investigated with a sensitive S1 nuclease assay. HGF mRNA levels are low in the ileum and increase only transiently post-MSBR. In contrast to the other models of regeneration, no increase in HGF mRNA levels is observed in the lung nor in kidney and liver post-MSBR. This suggests that the ileum does not release "injurin", the putative humoral mediator of the response of the lung observed after hepatectomy or nephrectomy.

Animals↗
PubMed1995

The bipartite tarsal navicular bone: radiographic and computed tomography findings.

Two cases of bipartite tarsal navicular bone are presented. The radiographic and computed tomography (CT) findings of this anatomical variant are described. Correct recognition of this entity is important, both because it may be the cause of symptoms per se, and because it may be misdiagnosed as a fracture. When plain films are not diagnostic, CT scanning is helpful in distinguishing between a fracture and this variant.

Adolescent↗
PubMed1992

A re-evaluation of the tissue-specific pattern of expression of the rat kallikrein gene family.

We have used reverse transcriptase-polymerase chain reaction (RT-PCR) analysis and insitu hybridization to further define the tissue and cell-specific pattern of expression of the rat kallikrein gene family. rKlk1 gene expression has been unequivocally demonstrated in the rat heart, ovary and testis. Similarly, rKlk3, 4 and 9 gene expression has been demonstrated in the testis/ovary, heart and testis respectively. Insitu hybridization has identified the expression of kallikrein gene family members to specific cell-types in the rat ovary (granulosa cell) and testis (germ cell).

Animals↗
PubMed1983

Late language development in a child unable to recognize or produce speech sounds.

A boy with severe quadriplegia who neither recognized nor uttered speech sounds acquired language. Until the age of 6 years he was considered to be of severely subnormal intelligence. At age 6 years 9 months he was introduced to a manual sign system. Subsequently he was able to read, write, converse, and produce imaginative stories. Attention and memory were unimpaired and affective and social responsiveness developed appropriately. The case history demonstrates the selective effects of brain lesions that, despite extensive damage, may spare functional systems necessary for cognitive and linguistic development. It highlights the difficulty in diagnosing and evaluating the intellectual and affective potential of a multihandicapped child without functional hearing or speech and emphasizes the importance of sign language as a communication channel and prerequisite for the acquisition of reading and writing skills.

Aphasia↗
PubMed1983

Hemisphere functioning and motor imitation in autistic persons.

Previous research has found that a high proportion of autistic individuals exhibit an atypical pattern of hemispheric specialization suggestive of impaired left hemisphere functioning: namely, right hemisphere dominance for both verbal and visual-spatial processing. Studies of brain-damaged persons have suggested that the left hemisphere is specialized for the use of nonverbal gesture. Since a major characteristic of autism is an impairment in the use of gesture, it was predicted that autistic persons would also show atypical hemispheric specialization for motor imitation. To test this hypothesis, hemispheric activation was measured using EEG recordings of alpha rhythm in autistic and matched normal control subjects during four motor imitation tasks. Autistic subjects showed significantly greater right hemisphere activation during the imitation tasks, than normal subjects. This pattern was particularly evident in younger autistic subjects and during oral, rather than manual, imitation tasks.

Adolescent↗
PubMed1981

Motor and cognitive interactions during lateralized cerebral functions in children: an EEG study.

Power spectra of hemispheric EEG asymmetries were recorded in children performing cognitive tasks requiring motor output. Verbal and spatial cognitive tasks were administered and subjects performed tasks with either right or left hand. The average power in the alpha band was computed. Significant changes in right/left ratios were obtained when the task changed from verbal to spatial. A major predictor of which hemisphere was most activated, however, was the hand involved in solving the task. It appears that attention must be directed to both the cognitive and motor components when investigating asymmetries of cerebral hemisphere function.

Adolescent↗