Biomedical subjects

P Fusaro

Publications and source records attributed to P Fusaro.

3 recordsLinked to original sources

PubMed1992

Short-term effects of ritodrine, aminophylline and atropine on umbilical artery blood flow velocity waveform.

With the recent introduction of Doppler technology, a non-invasive methodology which enables to evaluate qualitative changes in circulatory vessels, it is possible to investigate the possible effects of various drugs on several parameters of utero-placental-fetal circulation. In the present study we evaluate the flow velocity waveform (FVW) of umbilical artery (UA) during and after administration of aminophylline, atropine and ritodrine to healthy pregnant women. In our study we did not observe any significant short-term variation of PI after the administration of these drugs. Slight variations were detected, and they may be interpreted on the basis of the mode of action of these drugs. Doppler technology may be a useful tool for monitoring some effects on the fetus of the maternal administration of therapeutic agents.

Aminophylline↗

PubMed1990

[Decrease of blood lead in the Marche population, 1979-1989].

Blood lead concentration was measured from 1979 to 1989 in 1148 subjects (834 males and 314 females) living in Regione Marche of Italy. Blood concentration lowered in the time from 34.6 mcg/100ml in 1979 to 12.3 mcg/100ml in 1989. The greatest decrease was measured after 1982 and this appears to be related to the reduction, on the basis of CEE dispositions, of lead concentration in gasoline. Blood lead concentration was higher in males than in females (18.2 mcg/100ml vs 16.5 mcg/100ml) and in people living in the cities with more than 50.000 inhabitants (18.3 mcg/100ml). The smoking habit, the wine assumption and the use of canned foods do not influence blood lead concentration, which is instead increased in subjects which usually drink water drawn from artesian wells.

Adolescent↗

PubMedDate not supplied

The role of Doppler technology in the evaluation of fetal hypoxia.

Failing intrauterine support to the fetus can lead to intrauterine growth retardation (IUGR) and hypoxia and it is associated with a high risk of perinatal morbidity and mortality. The main effects of moderate to severe hypoxia on the fetus are different degrees of blood flow redistribution and reduction of oxygen consumption to maintain oxygen delivery to the central organs at the expenses of peripheral organs. The redistribution results in a 'brain sparing' effect. Recently, a Doppler ultrasonic technology (continuous wave, pulsed wave and colour flow imaging) has been developed for the non invasive measurement of flow. Doppler velocimetry detects the flow velocity waveform (FVW) which reflects the cardiac output, the vascular compliance and the resistance to the flow in a defined point of the vessel. Velocity waveform indices or even simpler criteria, such as the presence or absence of diastolic flow or flow reverse during diastole, have been applied to a number of fetal vessels. A significant relationship exists between blood oxygen, systemic lactic acidosis (determined by cordocentesis) and increase PI values in umbilical artery (UA), thoracic aorta (TA) and renal artery (RA). Moreover, in experimental animals during steady state hypoxia, several cardiovascular parameters are affected (heart rate/cardiac output decreases and blood pressure increases) while placental flow don't show a significant variation thus suggesting a raise in placental vascular resistance. Redistribution of the flow may be reliably evaluated by the cerebroplacental ratio (i.e. ratio between PI of MCA and PI of UA, c/p).(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗