Biomedical subjects

P G Darke

Publications and source records attributed to P G Darke.

At least 19 recordsLinked to original sources

PubMed2000

Progression of aortic stenosis in the boxer.

Thirty-five boxers that had been referred to the Royal (Dick) School of Veterinary Studies between 1989 and 1994 with left heart base murmurs and aortic velocities greater than 1.5 m/second on Doppler echocardiography were recalled for clinical examination and Doppler echocardiography between 1995 and 1996. Five dogs (14 per cent) showed an increase in murmur grade on repeat visit. Six dogs (17 per cent) showed an increase in aortic velocity of greater than 20 per cent. Eight dogs (23 per cent) had developed aortic valvular or subvalvular two-dimensional echocardiographic changes that had not been present at the initial visit. Seven dogs (20 per cent) had developed aortic regurgitation, and three dogs (8 per cent) mitral regurgitation.

Animals↗

PubMed1998

Doppler echocardiography. I. Pulsed-wave and continuous-wave examinations.

Doppler echocardiography is a specialized processing of cardiac ultrasound that is characterized by a continuously updated display of blood velocity during the cardiac cycle. Doppler examinations, which include color-coded Doppler echocardiography, pulsed-wave examination, and continuous-wave studies, are readily applicable to veterinary patients.

Animals↗

PubMed1997

Measurement of cardiac output in standing horses by Doppler echocardiography and thermodilution.

Measurement of cardiac output by Doppler echocardiography were compared to simultaneous measurements by thermodilution in 9 conscious horses. In the Doppler technique, mean blood flow velocities for estimation of cardiac output were recorded from the aorta and pulmonary artery. The flow area of each vessel was calculated from the vessel diameter, measured from a 2-dimensional ultrasound image. Differences in the site and method of measuring the vessel diameter altered the estimation of cardiac output by the Doppler method. Cardiac output was modified by the i.v. infusion of 4 micrograms/kg bwt/min dopamine and 4 micrograms/kg bwt/min dobutamine and by the i.v. administration of 10 micrograms/kg bwt detomidine and 20 micrograms/kg bwt butorphanol. Doppler measurements of cardiac output correlated closely with measurement by thermodilution. Measurements from the aortic outflow correlated more closely with thermodilution, than those from the pulmonary artery (r = 0.89 and r = 0.77, respectively). Doppler measurements when the mean flow velocity was recorded from the aorta and the flow area was measured from the ascending aorta using the leading edge method. There was no significant bias between the 2 techniques when Doppler flow velocities were recorded by this method and the limits of agreement were narrow (+/- 12.26 l/min). The differences between the 2 methods increased with increasing cardiac output. Doppler echocardiography is a safe noninvasive method of measuring cardiac output in horses. The agreement between Doppler echocardiography and thermodilution in this study is similar to that reported in man and is similar to that reported between thermodilution and other techniques in man.

Analgesics↗

PubMed1995

Feasibility of transoesophageal echocardiography for evaluation of left ventricular performance in anaesthetised horses.

Transoesophageal Doppler echocardiography was performed in 7 Thoroughbred horses anaesthetised with halothane. The procedure was performed on 4 occasions under standard conditions. On one occasion dobutamine hydrochloride was infused at 4 micrograms/kg/min for 20 min. Recordings of aortic blood velocity, obtained using high pulsed repetition frequency Doppler echocardiography (HPRF), were used to derive maximum acceleration (dv/dtmax), maximum velocity (Vmax), left ventricular ejection time (ET), pre-ejection period (PEP), velocity time integral (VTI) and cardiac output (CO). The coefficient of variation and 95% confidence intervals were narrower for the Doppler variables than for those obtained from cardiac catheterisation. For each horse the anaesthetic to anaesthetic repeatability of the Doppler indices of left ventricular function, exceeded that of maximum rate of rise of left ventricular pressure (LVdp/dtmax). The horse to horse variability was significant for heart rates Vmax, dv/dtmax, and VTI. After dobutamine infusion there were significant changes in all measured variables except heart rate, VTI and CO. The % change that occurred exceeded the predicted 95% confidence intervals for single measurements in all significantly affected variables. This suggests Doppler indices of cardiac performance may be useful to assess changes in haemodynamic function. Passage of the probe into the oesophagus was not associated with serious adverse effects. Mild serous nasal discharge was visible for up to 24 h after the horses recovered from anaesthesia. Mild nasal haemorrhage occurred on 5 occasions during probe insertion. It is concluded that transoesophageal Doppler echocardiography provides a minimally invasive, continuous method for monitoring left ventricular systolic performance in anaesthetised horses.

Adrenergic beta-Agonists↗

PubMed1992

Standardised imaging technique for guided M-mode and Doppler echocardiography in the horse.

Eighteen echocardiographic images useful for diagnostic imaging, M-mode echocardiography, and Doppler echocardiography of the equine heart were standardised by relating the position of the axial beam to various intracardiac landmarks. The transducer orientation required for each image was recorded in 14 adult horses by describing the degree of sector rotation and the orientation of the axial beam relative to the thorax. Repeatable images could be obtained within narrow limits of angulation and rotation for 14 of the 18 standardised images evaluated. Twenty-seven National Hunt horses were subsequently examined using this standardised technique. Selected cardiac dimensions were measured from two-dimensional and guided M-mode studies. Satisfactory results were achieved in 26 of the 27 horses. There was no linear correlation between any of the measured cardiac values and bodyweight. There was no significant difference between measurements taken from the left and the right hemithorax. Six horses were imaged on three consecutive days to assess the repeatability of the measurements. No significant difference was found between measurements obtained on different days. This study demonstrates a method for standardised echocardiographic evaluation of the equine heart that is repeatable, valuable for teaching techniques of equine echocardiography, applicable for diagnostic imaging and quantification of cardiac size, and useful for the evaluation of blood-flow patterns by Doppler ultrasound.

Animals↗

PubMed1991

Techniques and complications of pacemaker implantation in four cats.

Pacemakers were successfully implanted in 4 adult and geriatric cats with bradycardia and associated signs. Various implantation techniques were used. Complications developed in 3 of the cats, generally more severe in 2 of the 3 cats in which thoracotomy and celiotomy were performed than in the cat in which a transvenous endocardial pacing technique was used. After surgery, pacemaker functions were reprogrammed noninvasively in 2 cats. All 4 cats survived without syncope for a mean of 33.1 months after surgery.

Animals↗

PubMed1987