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Biomedical subjects

P G Delikaris

Publications and source records attributed to P G Delikaris.

13 recordsLinked to original sources
PubMed1999

The use of a dura mater patch to cover oesophageal defects of different sizes: an experimental study in chickens.

OBJECTIVE: To find out the optimal size of full thickness oesophageal defects that can be repaired with patches of Tutoplast Dura (solvent dehydrated human dura mater in the form of absorbable collagen). DESIGN: Experimental study. SETTING: Teaching hospital, Greece. MATERIAL: 96 female Hubbard chickens in four groups of 24. INTERVENTIONS: In the three experimental groups longitudinal defects were made in the cervical oesophagus 30 x 5, 10, or 15 mm and covered with Tutoplast. Subgroups of 6 chickens were weighed, had a barium swallow examination, and were then killed at 2, 4, 6, and 8 weeks. The oesophagus was removed and examined histopathologically. MAIN OUTCOME MEASURES: Weight, extent of healing macroscopically and microscopically. RESULTS: All chickens that had had defects 30 x 15 mm in size died between days 5 and 10, and the oesophagus in all cases was obstructed by food. There were no deaths or complications in the other three groups, and no evidence of dysphagia on barium swallow. In chickens with defects of 30 x 5 and 30 x 10 mm the prosthetic material gradually disappeared, and they healed well. CONCLUSIONS: Defects in the chicken's cervical oesophagus larger than 30 x 10 mm cannot be repaired with a Tutoplast patch, but smaller defects can. Further studies are needed to clarify the mechanisms of healing.

Animals↗
PubMed1984

Empyema thoracis--a prospective study on 73 patients.

A prospective study of empyema thoracis was conducted on 73 consecutive patients. The pathogenesis and bacteriological features of the condition and its clinical course and management are recorded and analysed. Pleural cultures revealed that the predominant pathogen was Staphylococcus aureus. Fifty of 65 patients had mixed isolates on pleural culture, with a 4:1 ratio of aerobes to anaerobes. Twenty per cent of the patients had anaerobic empyemas. The underlying lesion was parenchymal lung disease in 37 cases and an infected hemopneumothorax following penetrating injury in 26. The remaining 10 patients developed empyema after pulmonary resection. The empyema resolved completely in 81% of the patients.

Adolescent↗
PubMed1984

Pessimism concerning palliative bypass procedures for established malignant esophagorespiratory fistulas: a report of 18 patients.

Eighteen patients with established malignant esophagorespiratory fistulas due to primary esophageal cancer were managed by substernal gastric bypass and isolation of the cancerous esophageal segment. Seven fistulas were esophagotracheal and 11 were esophagobronchial. Ten patients died in the hospital between two days and six weeks after operation. Eight patients left the hospital, surviving an average of 3 1/2 months, but 2 patients lived 5 and 7 months, respectively. Unrelenting respiratory infection and clinical inanition caused 7 hospital deaths in patients reestablished on oral alimentation with their fistulas disconnected. Anastomotic leaks occurred in 5 patients; three of these leaks closed. In the other 2 patients, cervicomediastinal sepsis and bilateral pneumonia with respiratory failure caused death. One patient died of anoxic cardiac arrest 48 hours postoperatively. Fifteen of the 18 patients resumed oral alimentation, but the overall results of palliative surgical therapy achieved in this series were not observably worthwhile for the majority.

Adult↗
PubMed1983

The operative management of post-intubation tracheal strictures. Case reports.

The presentation and treatment of 2 patients with post-intubation tracheal strictures are reported. There was one subglottic and one supracarinal stricture, and they were treated by resection and anastomosis. The surgical procedures and special techniques for the facilitation of anastomosis are discussed, as is the subsequent management.

Adult↗
PubMed1977

Biliary bacteriology based on intraoperative bile cultures.

This paper presents a study of bile cultures taken during 174 operations on the extrahepatic biliary tract. Twenty-six per cent of the cultures were positive. Septic complications developed in 33.3% in this group. Since septic complications must be the result of intraoperative contamination from the infected bile, an argument is presented for prophylactic preoperative antibiotic administration as well as for routine culture of the bile at time of surgery.

Abscess↗
PubMed1976

Current thoughts on the surgical treatment of rectal cancer.

From August, 1971 to May, 1974, 52 cases of rectal cancer belonging to different groups, according to Mason's classification, were seen at the First Surgical Department, University of Athens Medical School. In the majority of the cases the tumor was removed by combined abdominoperineal resection; the variety of other surgical methods in the treatment of rectal cancer are discussed. Emphasis is focused on certain important technical aspects in the surgery of rectal cancer: 1. the need for thorough preoperative preparation of the bowel; 2. the ligation of the inferior mesenteric artery at its origin from the aorta; 3. the intraluminal infusion of cytotoxic agents into the tumor-bearing segment after ligation of the inferior mesenteric vein; 4. the idea of the intra-arterial regional chemotherapy, during the operation; 5. the demarcation of the area with radiopaque clips for acute postoperative radiation,when residual tumor is left behind. The authors consider adherence to the above technical details critical in achieving good surgical results.

Adenocarcinoma↗
PubMed1975

Lymphedema of the upper limb after surgery for breast cancer.

Radical mastectomy is followed by swelling of the arm, and although the number of surgeons employing the operation is decreasing, postmastectomy lymphedema continues to be a serious complication. In the present report based on 158 women who underwent modified radical (126) or simple (32) mastectomy and occasionally radiation for histologically proved adenocarcinoma of the breast, the pathogenesis and treatment of postmastectomy lymphedema are discussed. The following conclusions can be drawn: (1) The occurrence of postmastectomy lymphedema diminishes the less extensive the operation. (2) Mild lymphedema that develops early postoperatively tends to subside. (3) Conservative treatment in the majority of cases is effective in controlling postmastectomy lymphedema of a mild to moderate degree. (4) Modified radical mastectomy, which is as radical as Halsted's operation, is rarely followed by lymphedema.

Adult↗