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Biomedical subjects

P G Hazen

Publications and source records attributed to P G Hazen.

At least 19 recordsLinked to original sources
PubMed1998

Prenatal diagnosis for keratin mutations to exclude transmission of epidermolytic hyperkeratosis.

Epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma) is an autosomal dominant skin disorder caused by mutations in keratins 1 and 10. We have used direct gene sequencing to ascertain the status of a 15 week fetus of parents whose first child was affected with this disorder. The parents show no clinical signs of epidermolytic hyperkeratosis but were concerned about the possibility of transmitting the disorder due to germline mosaicism. Molecular analysis of the affected son revealed a G to A mutation in codon 156 of keratin 10, resulting in an arginine to histidine substitution within the highly conserved 1A region. Codon 156 has been previously identified as a mutational hot spot and substitutions of this arginine residue are very common in epidermolytic hyperkeratosis patients. Analysis of genomic DNA isolated from amniotic cells showed that the fetus did not harbour this mutation and a healthy infant was eventually born that was unaffected by this disorder.

Amniotic Fluid↗
PubMed1995

Management of lacerations in sports: use of a biosynthetic dressing during competitive wrestling.

Lacerations occur commonly during competitive contact sports. Such injuries often limit the ability of the athlete to continue competition because of concerns about further trauma to the site and risks of infection. We describe herein the use of a biosynthetic dressing, Duoderm Thin, to protect lacerations received during competitive wrestling. The dressing was able to support the skin, protect the laceration from further injury, shield the wound from exposure to infectious agents, and prevent transmission of blood or serum to other wrestlers. Such protection enabled two wrestlers to continue competition and/or practice without adverse effects.

Adolescent↗
PubMed1992

Keratitis, ichthyosis, and deafness (KID) syndrome: management with chronic oral ketoconazole therapy.

Extensive cutaneous mycoses have been described in patients with the keratitis, ichthyosis, and deafness (KID) syndrome. We present a case occurring in a 48-year-old woman where improvement in the ichthyosiform dermatosis, stabilization of her ocular disease, and apparent partial prevention of further cutaneous malignancies occurred in association with ketoconazole therapy.

Administration, Oral↗
PubMed1989

The superficial mycoses and the dermatophytes.

More than 100,000 species of fungi have been identified worldwide, but only a few dozen are of medical significance. Because of the opportunistic nature of these organisms and the prevalence of immunodeficient conditions, the number of medically important fungi is increasing. Identification of the causative organism is of value in the choice of correct therapy. The development of new antifungal drugs has made it increasingly important to be able to distinguish one fungus from another. This article reviews the laboratory diagnosis of the fungi generally classified as the superficial mycoses and the dermatophytes.

Antifungal Agents↗
PubMed1989

Skin cancer awareness programs: success of a statewide program of education and screening in Ohio.

Skin cancer has been increasingly identified as an important public health concern. Dramatic increases in the incidence of skin malignancies have led the dermatologic community in Ohio to organize a statewide program of education and free public screenings. The program reached multiple geographic areas throughout Ohio. Educational programs were presented on television and radio, in newspapers, in independent programs, and in schools. Skin cancer screenings ultimately evaluated 5,492 patients. Six hundred and twenty-three patients were found to have suspected malignancies, while an additional 1,647 patients were found to have premalignant lesions of skin. A total of 2,370 patients were therefore found to have significant findings (43.2%). These results emphasize the need for public education concerning this condition.

Health Education↗
PubMed1985

Disseminated superficial actinic porokeratosis: appearance associated with photochemotherapy for psoriasis.

A patient with chronic psoriasis treated with psoralens plus ultraviolet A (PUVA) developed characteristic lesions of disseminated superficial actinic porokeratosis (DSAP). Since other processes associated with ultraviolet irradiation, including epidermal dysplasia, actinic keratoses, squamous cell carcinomas, and keratoacanthomas, have been reported to result from PUVA, it is possible that her DSAP lesions were induced by this therapy.

Adult↗
PubMed1984

Basal cell nevus syndrome. Unresponsiveness of early cutaneous lesions to topical 5-fluorouracil or dinitrochlorobenzene.

A single patient with basal cell nevus syndrome is presented. Prolonged application of 5% 5-fluorouracil and dinitrochlorobenzene was unsuccessful in inducing regression or clearing of his cutaneous lesions. Our results suggest that these therapies, at least for the nevoid-appearing lesions, may not be effective in the management of some patients with basal cell nevus syndrome.

Administration, Topical↗