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Biomedical subjects

P G McGing

Publications and source records attributed to P G McGing.

9 recordsLinked to original sources
PubMed1990

Non-M CK--a practical measure of creatine kinase isoenzymes in cancer patients.

The individual creatinine kinase (CK) isoenzymes CK-BB and CK-Macro II have previously been investigated as potential tumour markers. We believe there is a need for a system to measure those CK forms not usually present in serum. We have studied a CK-MB immunoinhibition kit which measures all residual CK activity following inactivation of M-subunit activity. In 162 patients with cancer we found no difference in grading (+ or -) between detailed isoenzyme studies and the simple non-M assay. In 33 samples with elevated non-M CK, detailed analysis showed BB alone (45%), Macro II alone (9%), or both (36%). Raised activities were mainly found in patients with small cell lung cancer (SCLC) (17/40; 43%) and GI Tumours (6/11; 55%). In patients with SCLC, elevated activities were associated with disseminated disease. Preliminary evidence indicates that Non-M CK may also be a simple means of monitoring initial treatment response.

Biomarkers, Tumor↗
PubMed1981

Evidence that the decreased liver folate status following vitamin B-12 inactivation in the mouse is due to increased loss rather than impaired uptake.

Using N2O to inactivated B-12, mouse liver polyglutamate distribution has been examined at short time intervals after injection of [3H]pteroyglutamate. An increased monoglutamate pool is found initially which is lost by 24 h. This finding strongly supports the suggestion that the reduction in total liver folate in vitamin B12 deficiency is due to increased loss rather than decreased uptake.

Animals↗
PubMed1980

The role of methionine and vitamin B12 in folate incorporation by rat liver.

The decreased folate uptake induced by exposure of rats to nitrous oxide can be partly reversed by methionine supplementation. This is consistent with the theory that N2O inhibits methylcobalamin-dependent methionine synthetase (EC 2.1.1.13) in rat liver and previous observations showing decreased folate incorporation in rats made nutritionally vitamin B12 deficient.

Animals↗
PubMedDate not supplied

A study of PSA requests from general practitioners received by one Dublin hospital.

Patterns of PSA requesting by General Practitioners were studied in one Dublin hospital for 11/1994-8/1995 and 11/1996-8/1997. 58% of requests (421/723) had PSA < 2ug/L and 82% had PSA < 4ug/L. Patients under 60 years accounted for 32% of the total requests but only 7% of these showed PSA levels over 4ug/L. PSA requests on these younger patients constitute a significant proportion of the PSA workload and yet appear to have low diagnostic yield. The mean age for all patients studied dropped from 68 years in 1994/1995 to 63 years in 1996/1997. This may reflect an increasing tendency to test all men over 50 years of age. This review of PSA requesting within our hospital's catchment area supports the view that PSA testing is not focused on higher risk individuals and shows tendencies towards a screening approach.

Aged↗