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Biomedical subjects

P G Raman

Publications and source records attributed to P G Raman.

At least 19 recordsLinked to original sources
PubMed2002

Gallbladder disorders and type 2 diabetes mellitus--a clinic-based study.

AIMS OF THE STUDY: To study the prevalence of gallbladder disorders in type 2 diabetic patients and their correlation with patient factors like age, sex, weight, duration of diabetes and autonomic neuropathy. METHODOLOGY: Fifty type 2 diabetic patients and 30 healthy controls underwent realtime ultrasonography to study the prevalence of gallbladder disorders. The fasting gallbladder volume and contraction 60 minutes after a fatty meal of the diabetic subjects were compared with 30 age and sex matched healthy volunteers. The age, sex, weight, duration of diabetes, autonomic neuropathy, control of diabetes were correlated to the prevalence of gallbladder disorders in diabetic patients. RESULTS: 32% of the diabetic patients had ultrasonographic evidence of gallstones, as compared to 6.7% in healthy subjects. 73.7% of the diabetic patients with gallbladder disorders were females. Mean fasting gallbladder volume was significantly increased in diabetic patients (26.2 cm3) as compared to non-diabetic healthy subjects (15.8 cm3). Further mean fasting gallbladder volume of diabetic patients with gallbladder disorder (28.1 cm3) was found to be significantly larger than that of those patients without gallbladder disorder (24.6 cm3). Mean percentage of contractions of gallbladder 60 min after fatty meal was reduced in diabetic patients (53.1%) and it was observed to be further reduced in the patients with gallbladder disorder (41.8%). Mean fasting gallbladder volume was larger in diabetic subjects with autonomic neuropathy, than those without. However, difference in mean percentage contraction of gallbladder 60 min after fatty meal was not statistically significant. Mean duration of diabetes was significantly longer in diabetic patients with gallbladder disorder. CONCLUSIONS: We conclude that type 2 diabetic patients have increased prevalence of gallbladder disorder which can only partially be explained by autonomic neuropathy leading, to increased fasting volume. Factors like decreased cholecystokinin or decreased sensitivity of the smooth muscle of gallbladder to normal level of cholecystokinin need to be studied.

Diabetes Mellitus, Type 2↗
PubMed2002

Nature of lesion in cerebrovascular stroke patients: clinical stroke score and computed tomography scan brain correlation.

AIM: To differentiate between cerebral infarct and intracerebral haemorrhage on the basis of clinical stroke score (Siriraj Stroke Score and Guy's Hospital Score) and to find out the sensitivity and overall accuracy of these scoring systems by comparing it with CT scan findings. MATERIAL AND METHODS: Two hundred patients with acute stroke were analysed by Siriraj and Guy's Hospital Score simultaneously CT scan was performed and patients with subarachnoid haemorrhage, tuberculoma, tumours and trauma were excluded. RESULT: CT scan revealed cerebral infarction in 152 (76%) patients and cerebral haemorrhage in 48 (24%) patients. The sensitivity of Siriraj Stroke Score was 92.54% for infarction and 87% for haemorrhage (equivocal and infratentorial cases were excluded) and it's overall accuracy was 91.11%. The Guy's Hospital Score had a sensitivity of 93.42% for infarction, 66.66% for haemorrhage and overall accuracy was 87%. CONCLUSION: Siriraj Stroke Score is easier to use at bed side and has a greater accuracy (especially in diagnosis of haemorrhage) than the Guy's Hospital Score.

Aged↗
PubMed2001

Ankle brachial index as a predictor of generalized atherosclerosis.

OBJECTIVE: To assess ankle brachial index (ABI) as a screening method to target subclinical atherosclerosis in middle aged individuals. MATERIAL AND METHODS: Total 160 patients over the age of 40 years were included in the study for a period of 16 months. Their ABI was determined either by colour Doppler method (30 patients) and/or sphygmomanometry (all 160 patients). A value of < 0.9 was taken as cutoff point for significant stenosis. RESULTS: Total 69 patients out of total of 160 had significantly low ABI value (43.12%) which shows that there is a very high incidence of low ABI in the community. Overall > 50% of the patients were largely asymptomatic and had presence of two or more risk factors. ABI < 0.9 was a good screening test to detect such individuals at an earlier stage (sub-clinical). CONCLUSION: A significantly low (< 0.9) ABI value can detect subclinical atherosclerotic vascular involvement and predict future occurrence of preventable major vascular event.

Adult↗