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Biomedical subjects

P G Reitnauer

Publications and source records attributed to P G Reitnauer.

At least 55 records · Page 3Linked to original sources
PubMed1978

[Overacidified tissue and microcirculation (author's transl)].

A discussion of physiological fundamentals with respect to the inhibition of blood microcirculation in (tumor) tissue at reduced pH values around 6.0 is followed by a report on principles, design and results obtained with a light probe array which permits to determine in vivo reference values of the relative intensity of microcirulation in both normal and tumor tissues under various conditions. An analysis of the discussed records has shown that--as compared to a value of 80-66% without glucose infusion--the relative mean intensity of microcirculation in tumor tissue drops to approximately 8-4% about 300 min after the onset of glucose infusion under CMT administration at 37 degrees C. By adding the CMT step of hyperthermy, the relative mean intensity of microcirculation--compared to normal tissue at 37 degrees C--will further drop below 1%. With such a decline of microcirculation--and an adequate duration of, say, 8 hours--local hyperthermy at 41-42 degrees C is likely to cause a very pronounced damaging action on tumor tissue because the then noticeably reduced substrate offer proves to be insufficient to ensure the structure-maintaining metabolic rate of cancer cells.

Animals↗
PubMed1977

[Selective local hyperthermy of tumor tissue. Homogenized energy supply also to deep-seated tissues by high-performance decametric wave coil section plus dual system raster motion (author's transl)].

Based on results of selective tumor tissue hyperacidification and whole-body hyperthermy the paper deals with the advantages of local hyperthermy and gives a review of the various methods of energy supply for hyperthermy in living tissue. It follows a presentation of physical and biophysical fundamentals on selective local hyperthermy of tumor tissue by radiation, by r. f. rotational magnetic fields and by r. f. capacitor fields. Using a gelatine phantom for measuring the energy supply with the various modes of local hyperthermy it is then shown that it is solely the divergent rotational magnetic field which allows to substantially reduce the inhomogeneity of energy supply also in z-direction (increasing depth in body tissue) by introducing a relative raster motion of the applicator in x-y-direction (plane parallel to body surface). It is only the introduction of the x-y raster principle combined with a described dual system array (CMT Selectotherm System) which permits the high and rather homogeneous supply of thermal energy also to deep-seated tumor tissue in the patient without concomitant critical superheating of tissues near the skin. Finally the paper gives a theoretical derivation of the temperature profile for selective local hyperthermy of tumor tissue. With due consideration of heat dissipation by convection and conduction, this endeavour shows rather promising aspects for the therapeutic efficiency obtainable in each case of treatment.

Animals↗
PubMed1977

[Collected findings of long-lasting chemical stimulation of the immune system by N-(2-cyanethylene)-urea derivatives (author's transl)].

The present paper describes our findings so far on the long-lasting chemical stimulation of the immune system by means of various batches from the synthesis of N-(2-cyanethylene)-urea (BA 1). These findings were also supported by results of other authors. Furthermore some recent findings have demonstrated that 2-cyanaziridine, 2-cyanethyl-urea and a bicyclic isomer represent examples for immunologically effective BA 1-derivatives or BA 1-isomers, respectively.

Animals↗
PubMed1976

[Temperature measurements in Wistar rats and DS carcinosarcoma under various conditions].

Temperature measurements on Wistar rats with miniature-Hg-thermometer and laser-welded thermoelements lead to the following conclusions: 1. No change of temperature-profile, especially in the liver through glucose-infusion and hyperthermia, can be noticed. 2. Glucose-infusion causes hyperthermia of about 1.5 degrees C. 3. The temperature of the subcutaneous growing DS- carcinosarcoma lies under the norm and increases with the distance from the surface of the body. 4. Hyperthermia of 3 degrees C has no influence on tumor over-acidification. 5. The substance CEU has no pyrogenic effect on the rat but potentiates the decrease of the body-temperature caused by narcosis.

Animals↗
PubMed1976

[Tumor hyperacidulation through glucose infusion enhanced by nicotinamide adenine dinucleotide (author's transl)].

Tumor peracidity in Walker carcinosarcoma 256-bearing Wistar rats attained by glucose (Gk) infusion was significantly (t-Test; p = 3.49) increased by a following infusion of 200 mg NAD in 7 ml 40 per cent. Gk-solution. The mean pH values obtained on six animals amounted 6.88 (start), 5.21 (after Gk) and 5.79 (after Gk + NAD). Three animals were cured through the hyperacidification process.

Animals↗
PubMed1975

[A measuring probe for glucose. 2. International state; further measurements, studies and experiences with the glucose probe].

Subsequent to the first paper and complementary to it, the present one gives a survey of the international state of work at a glucose probe (and an artificial pancreas) as well as additional methodical advice. It then discuss the glucose probe and its measuring properties including the possibility of kinetic measurement. It also deals with other probe systems, the use of carrier-fixed enzymes and the problem of miniaturization. The paper concludes with an economic consideration and an evaluation of the results of obtained.

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