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Biomedical subjects

P G Shakespeare

Publications and source records attributed to P G Shakespeare.

At least 19 recordsLinked to original sources
PubMed2005

Advances in wound healing: topical negative pressure therapy.

In clinical practice many wounds are slow to heal and difficult to manage. The recently introduced technique of topical negative pressure therapy (TNP) has been developed to try to overcome some of these difficulties. TNP applies a controlled negative pressure to the surface of a wound that has potential advantages for wound treatment and management. Although the concept itself, of using suction in wound management is not new, the technique of applying a negative pressure at the surface of the wound is. This paper explores the origins and proposed mechanisms of action of TNP therapy and discusses the types of wounds that are thought to benefit most from use of this system.

Acute Disease↗
PubMed2004

EBA in evidence.

Explore the source record for details and available documents.

Burns↗
PubMed2000

Using the pulsed dye laser to influence scar formation after breast reduction surgery: a preliminary report.

Many patients undergoing bilateral breast reduction surgery develop problems. Foremost among these problems is scar hypertrophy and its attendant symptoms. Although there is as yet no firm prognostic indicator for hypertrophy, scars that become hypertrophic often have a particular blood vessel pattern, observable by transcutaneous microscopy, showing vessels that lay transversely across the incision line with minimal crosslinks between them. Hypertrophic scars that develop in incision lines become wide, with the final width of the scar dependent on the maximum thickness during the growth stages before maturation and resolution. Close monitoring of scars forming in the incision line using the transcutaneous microscope detected this aligned vessel pattern before overt hypertrophy was seen. Use of the Pulsed Dye Laser caused disruption in the vessel pattern, appeared to inhibit additional hypertrophic development, and promoted early maturation of scars.

Cicatrix, Hypertrophic↗
PubMed1997

Treatment of hereditary haemorrhagic telangiectasia by the pulsed dye laser.

Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome, Osler's disease) is an inherited abnormality of the vasculature characterized by abnormal subepithelial vessels. Treatment has included repeated intranasal cautery, intra-arterial embolization and arterial ligation. Historically, the operation of septodermoplasty and the use of systemic/topical oestrogens have been the most effective and lasting treatments, but over time the telangiectasias recur. There is increasing interest in the use of a variety of lasers for intranasal photocoagulation. A report of nine patients suffering from hereditary haemorrhagic telangiectasia who have undergone laser treatment with the Chromos pulsed dye laser is presented. This laser produces light energy at a wavelength of 585 nm and causes localized thermal damage to the blood vessel wall. Initially, no patient saw an improvement in their symptoms, but following an average of approximately three courses of treatment, all have reported a measurable reduction in the number of epistaxes suffered. Although no treatment completely resolves the epistaxis associated with this condition, we have found the pulsed dye laser to be effective at treating telangiectasias within the anterior nasal cavity.

Adult↗
PubMed1996

Timing of the thermographic assessment of burns.

The thermographic assessment of burns using infrared imaging has previously been shown to be a useful aid in the estimation of burn depth. In this study, thermographic images of burns, obtained from 65 patients over a 4-year period, were reviewed. An infrared transparent, water-impermeable membrane was used as a wound cover to abolish evaporative cooling artefacts. Single images were obtained from patients with burns to various parts of the body, excluding the hands. A significant change in the temperature of deep burns was observed between days 2 and 3 after injury (chi-square, P < 0.01; Fisher exact probability test between days 2 and 3, P < 0.01). The results of this study suggest that thermography of burns, to assess depth, should be performed within 3 days following the injury.

Adolescent↗
PubMed1995

Burns in octogenarians.

With the aim of identifying patterns of burn injury, remediable risk factors, and policies in the overall surgical and medical management a retrospective review of 111 octogenarian burn victims admitted between 1983 and 1993 is presented. The mean age was 84 years, with the mean percentage body surface area burned (%BSAB) being 9.6 per cent (range 0.5-65 per cent). Contrary to expectations, the annual incidence appears to be declining, the possible reasons for which are discussed. Surgery was required in 69 patients; in 11 this was performed within 1 week of injury. When compared to the more traditional delayed surgical approach, early surgery conveyed no benefits in either mortality (early group, 18 per cent; delayed group, 13 per cent) or length of hospital stay (early group survivors, 38 days; delayed group survivors, 42 days). Medical and social problems were very common and led to an often difficult and frequently prolonged rehabilitation, with the mean length of hospital stay for all patients being 29 days. The mortality of the whole group was 26 per cent, the patients on average faring better than their predicted mortalities as derived using either the Baux index, the Bull table or the Abbreviated Burn Severity Score.

Age Distribution↗
PubMed1993

Surface ultrastructure of human dermis and wounds.

Scanning electron microscopic observations of the de-epidermalized surfaces of wounds and control skin reveal the architecture of dermal collagen. At wound edges there is a transition from the normal regular rete peg structure through erratically shaped finger-like projections with buds, to the relatively flat surface of granulation tissue. A corresponding change in the ultrastructure of dermal collagen is seen from normal areas where bundles of thick fibres are made up from finer fibrils, through a transitional zone where only fine fibrils are visible, to the granulation tissue where a disorganised amorphous structure is seen. It is suggested that the fibrous tissue surface at the edges of healing wounds is extensively remodelled after it is covered by epidermal cells.

Basement Membrane↗