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Biomedical subjects

P G Wiles

Publications and source records attributed to P G Wiles.

At least 19 recordsLinked to original sources
PubMed2003

A pilot randomized trial in primary care to investigate and improve knowledge, awareness and self-management among South Asians with diabetes in Manchester.

AIMS: To investigate whether a secondary-primary care partnership education package could improve understanding of diabetes care among South Asians. METHODS: In a pilot randomized controlled trial, in the setting of eight general practices randomized to intervention or control, patients were invited to four or more rotating visits per year by one of a diabetes specialist nurse, dietician or chiropodist working with general practice staff. Participants were from lists of South Asian patients with known Type 2 diabetes in each (general) practice. RESULTS: Patients and practice scores at baseline and 1-year follow-up, from an interview using a questionnaire on knowledge, awareness and self-management of diabetes. Responses were developed into educational packages used during intervention. Of the 411 patients listed at baseline only 211 were traced for interview (refusal only 4%). Mean age was 55.4 years, age of diabetes onset 47.1 years. Fourteen percent were employed and 35% were able to communicate in English fluently. Only 118 could be traced and interviewed at 1 year, although there was no significant difference in demography between those who completed the study and those who did not. Despite a mean of four visits/patient, intervention had no impact on scores for diabetes knowledge, or awareness [score change 0.14, 95% confidence interval (CI) -0.20, 0.49] or self-management (-0.05, 95% CI -0.48, 0.39) between baseline and 1 year. CONCLUSIONS: This form of secondary/primary care support did not transfer information effectively, and we suspect similar problems would arise in other similar communities. Different methods of clinician/patient information exchange need to be developed for diabetes in this South Asian group.

Adult↗
PubMed1999

Diabetic ketoacidosis precipitated by thyrotoxicosis.

We report two patients with type 1 diabetes mellitus, previously well controlled with good compliance, presenting with unexplained diabetic ketoacidosis. Following initial correction of the metabolic disorder, persisting tachycardia lead to the diagnosis of thyrotoxicosis. In both cases, treatment with propranolol and carbimazole helped in the stabilization of their metabolic states. Although thyrotoxicosis is known to destabilize diabetes control, we can find no reports of it precipitating diabetic ketoacidosis.

Adult↗
PubMed1999

Thyrotoxicosis in old age: a different clinical entity?

Thyrotoxicosis generally presents with classic signs and symptoms in younger people. Among the elderly population atypical presentation is recognized, although this has not been well quantified or characterized. To avoid misdiagnosis or delay in diagnosis, clinical suspicion needs to remain high.

Aged↗
PubMed1997

A comparison of qualitative and quantitative research methods used to assess knowledge of foot care among people with diabetes.

Many diabetes-related pathologies, especially among neuropathic patients, are potentially avoidable. Prevention, however, requires appropriate knowledge and understanding. To assess our ability to effect change in behaviour we need adequate tools to measure not only knowledge but also understanding and change of behaviour. To assess individuals' knowledge and beliefs towards diabetic footcare, we used both quantitative and qualitative methods: a structured questionnaire composed of 20 questions was completed by the respondent, followed by a semi-structured interview conducted by the chiropodist. Results from the structured questionnaire were inconsistent with those from the interviews (Wilcoxon test, p < 0.008). The former demonstrated an average knowledge score of 45% while performance during the interview generated data which suggested poorer knowledge levels. Respondents who correctly identified a series of statements regarding diabetic footcare within the questionnaire could not then apply this knowledge meaningfully when interviewed. A structured questionnaire may not be the best means of assessing patients' knowledge and understanding. We need not only to improve patient education regarding footcare, but also to improve our means of measuring patient knowledge and understanding, more accurately to assess the success or otherwise of our interventions.

Aged↗
PubMed1995

Cushing's syndrome: still a potential killing disease.

When Harvey Cushing described his syndrome in 1932 he named it the killing disease because of its cardiovascular complications. Heart failure is rarely reported as a presenting feature. We report a case in which left ventricular failure (LVF) was the predominant feature, associated with gross left ventricular hypertrophy (LVH) which regressed after treatment.

Adrenal Gland Neoplasms↗
PubMed1993

The degree of day-to-day variation in food intake in diabetic patients.

A prospective study of food intake using 7 day food diaries was undertaken in 92 diabetic men and women aged 17-81 years. The median individual day-to-day coefficients of variation for energy intake were: in insulin treated patients 12.0%, in non-insulin treated patients 13.7%; for carbohydrate intake 14.5% and 13.8% and for fat 20.7% and 20.8%, respectively. The median individual differences between the minimum and maximum daily intake of energy in insulin treated patients was 787 kcal, in non-insulin treated patients 649 kcal, for carbohydrate intake 89g and 77g and fat 50g and 43g, respectively. Only 39% patients ate within 20% of their prescribed carbohydrate diet. In non-insulin treated patients on prescribed calorie controlled diets, calorie consumption was on average 46% in excess of that prescribed. Although the variation in dietary intake in diabetic patients is large, it is smaller than that reported in non-diabetic subjects in the UK. This variation is likely to make the manipulation of other antidiabetic therapy both difficult and somewhat arbitrary.

Adult↗
PubMed1992

Diabetic diets and nutritional recommendations: what happens in real life?

Prospective 7-day estimated weight food records were computer analysed in 92 diabetic patients, 45 men and 47 women, 25 with Type 1 and 67 Type 2 diabetes, attending a hospital-based diabetic clinic. The nutrient intakes were compared with a national survey in non-diabetic British adults (OPCS) and the current EASD recommendations for the diabetic diet. Only three diabetic patients achieved the recommended 50-60% energy intake as carbohydrate, four achieved less than 30% energy as fat, one patient less than 10% saturated fat and 20 ate greater than 30 g fibre per day. The overall nutrient intakes of these diabetic patients reflected those of non-diabetic subjects except for a greater intake of protein and smaller intakes of sugar and alcohol. These findings reinforce the problems currently faced in achieving the present recommendations for the diabetic diet.

Adult↗
PubMed1991

Early loss of neurogenic inflammation in the human diabetic foot.

1. Neurogenic inflammation, mediated by nociceptor C fibres, is part of the acute neurovascular response to injury producing the axon reflex flare. Laser Doppler flowmetry was used to measure the flare response induced by the electrophoresis, at various current strengths, of a ring of acetylcholine solution into dorsal foot skin. 2. Nineteen control subjects and 52 long-duration insulin-dependent (Type 1) diabetic patients of similar age (20 without complications; 19 with laser-treated retinopathy; 13 with reduced vibration perception and retinopathy) were studied in order to investigate the possible attenuation of this defence mechanism in diabetes. 3. The maximal (1 mA) flare response [control median (interquartile range): 1.55 (1.16-2.06) arbitrary units] was reduced greatly in neuropathic patients [0.37 (0.24-0.66) arbitrary units; P less than or equal to 0.001 with respect to all other groups], especially those with a previous history of foot ulceration. The flare was also reduced in some patients with retinopathy alone [1.06 (0.56-1.27) arbitrary units; P less than 0.005 with respect to control subjects]. 4. No rightward shift of the curve of hyperaemic response plotted against current strength was found, suggesting that the abnormal response was due to axonal loss rather than to dysfunction. 5. Neurogenic inflammation, mediated by small pain fibres, was markedly impaired in a group of diabetic patients at risk of foot ulceration. Furthermore, impairment of this nociceptor C fibre response can develop before clinical large-fibre neuropathy and could itself predispose to foot complications.

Acetylcholine↗
PubMed1990

Therapeutic defibrinogenation by ancrod: effect on limb blood flow in peripheral vascular disease.

Reduction of blood viscosity by venesection may improve peripheral blood flow but similar haemorheological changes have not been conclusively demonstrated following reduction of plasma viscosity by defibrinogenation. Ancrod is a defibrinogenating enzyme from the venom of the Malayan pit viper. We studied six male patients with severe intermittent claudication before, during and after treatment with ancrod for 48 h. Ancrod was given by initial infusion of 2 U/kg over 6 h and four subsequent bolus i.v. injections of 2 U/kg. Skin blood flow in feet and toes were measured repeatedly by laser Doppler velocimetry and calf blood flow by electronic plethysmography both before and after 2 min arterial occlusion. Plasma fibrinogen [median (range)] fell from 2.3(1.4-3.9) to 0.1(0.1-0.3) g/l and plasma viscosity from 1.81(1.61-1.90) to 1.49(1.45-1.72) cp. Dorsal foot and toe skin blood (resting or post-ischaemic) flows were not changed significantly by ancrod. Resting calf blood flow fell significantly after 49 h treatment with ancrod (P less than 0.04). Brachial and ankle blood pressures remained unchanged and haematocrit was not changed. Thus, treatment with ancrod for 48 h did not improve peripheral blood flow in patients with peripheral vascular disease. The fall observed in calf blood flow could be related to increased circulating fibrin/fibrinogen high-molecular-weight complexes and degradation products.

Adult↗
PubMed1990

Reactive hyperaemia in skin of the human foot measured by laser Doppler flowmetry: effects of duration of ischaemia and local heating.

The effect of duration of ischaemia and of local heating on reactive hyperaemia in dorsal foot skin was determined in normal subjects using laser Doppler flowmetry. In the nine subjects studied, peak post-ischaemic blood flow continued to increase significantly with up to 10 min ischaemia and mean peak response was positively correlated with duration of ischaemia (r = 0.997, p less than 0.0002). This is in contrast to whole limb plethysmographic studies which have reported maximal peak flow responses after 3-5 min arterial occlusion. Resting blood flow was found to increase rapidly at skin temperatures above 33 degrees C. In ten subjects, local conductive heating from a median (range) skin temperature of 29.8(26.5-31.0) to 32.5(32.2-33.1) degrees C increased peak flow response after 4 min ischaemia from a mean (95% confidence interval) of 0.778(0.630-0.926) to 0.965(0.788-1.142) arbitrary units, p less than 0.001. The time course of the hyperaemic response was not altered. Local skin warming reduced the within subject coefficient of variation for peak response, calculated from 10 paired recordings, in two out of three subjects. These results show that the duration of ischaemia required to produce a maximal post-ischaemic peak flow response is longer for foot skin than for the whole limb and are consistent with temperature differences being the cause of this. A standard skin temperature (32-33 degrees C) may be useful for studying cutaneous blood flow responses.

Adult↗
PubMed1989

Reduced hyperaemia following skin trauma: evidence for an impaired microvascular response to injury in the diabetic foot.

The hyperaemic response to standard needle injury within dorsal foot skin was investigated in normal and Type 1 (insulin-dependent) diabetic subjects using laser Doppler flowmetry. The normal response was maximal within 15 min, localised, prolonged and biphasic. In 20 normal subjects and three groups of long-duration Type 1 diabetic patients (20 without complications; 20 with laser-treated retinopathy; 15 with neuropathy and retinopathy), the median (interquartile range) peak hyperaemic responses were 1.766 (1.220-1.970), 1.485 (1.342-1.672), 0.997 (0.705-1.203) and 1.030 (0.718-1.369) arbitrary units, respectively. Compared to normal and uncomplicated diabetic groups, peak flow was significantly reduced in the retinopathic (p less than 0.0001) and neuropathic (p = 0.001 and 0.007, respectively) groups. There was no significant difference between the normal and uncomplicated diabetic groups, nor between the retinopathic and neuropathic groups. There was no association of the hyperaemic response with blood sugar, HbA1c, or duration of diabetes. Diabetic patients who have microvascular complications, with or without neuropathy, have an associated impairment of microvascular response to mechanical injury which might predispose to infection and poor wound healing.

Adult↗