Biomedical subjects

P Gérome

Publications and source records attributed to P Gérome.

5 recordsLinked to original sources

PubMed2005

[Subacute meningoradiculomyeloencephalitis due to cryptococcosis infection].

INTRODUCTION: If meningoencephalitis with or without mass lesion (granuloma or abscess) is the most common pattern of CNS cryptococcal infection, intramedullary involvement is very uncommon. EXEGESIS: The authors report an 70-year-old male with Hodgkin's disease treated by chemotherapy then corticosteroids because of pulmonary fibrosis who was presenting for eight days ago, an ataxia, pyramidal syndrome, and bradypsychy. Spinal MRI revealed a gadolinium T1 weighted homogeneous enhancing T4 level intramedullary lesion. CSF had showed 190 GB/mm3 of lymphomonocytes, increased protein level (2.28 g/l), decreased glucose level (1.5 mmol/l) and positivity for crytococcal antigen. Treatment by amphotericine B and flucytosine then fluconazole for six months was instituted and symptoms gradually improved. CONCLUSION: A cryptococcus infection must be searched by antigen in CSF in case of myelopathy isolated or associated with meningoradiculoencephalomyelopathy, specially in patients with a cellular immunodeficience. Antimycotic agents must be firstly used, surgery would be restricted to decompression if aggravation of disease and compressive effect on the adjacent structures radiologically (MRI) became evident. Prolonged treatment is necessary in case of immunodeficience.

Aged↗

PubMed2004

Comparative diagnostic performance of two commercial rapid tests for malaria in a non-endemic area.

In the study reported here, the diagnostic performance of two new rapid tests for the diagnosis of malaria was evaluated in symptomatic patients in a non-endemic area. Of 557 consecutive patients, 109 (19.6%) had documented malaria. For the NOW ICT MALARIA P.f./P.v. (Binax, Portland, ME, USA) and OptiMAL IT (Diamed, Cressier, Switzerland) tests, respectively, sensitivity values were 96.3% and 79.8% (P-value, 0.0001), and specificity values were 98.8% and 98.4%. The NOW ICT test did not detect two of 80 Plasmodium falciparum infections, and it generated false-positive results for five patients. The OptiMAL IT test failed to detect ten of the P. falciparum infections, and it generated seven false-positive results. The results suggest that these rapid diagnostic tests for malaria may be useful, but they cannot replace microscopic examination of blood films.

Adolescent↗

PubMed1996

Study of Pseudomonas aeruginosa serotype O12 isolates with a common antibiotic susceptibility pattern.

A multicentre European study of Pseudomonas aeruginosa serotype O12 isolates with a common antibiotic resistance pattern was conducted. Resistance to beta-lactams and aminoglycosides was observed in 24 of the 25 isolates, as often reported in Europe, and all 25 isolates were significantly more susceptible to fosfomycin than 189 isolates of other serotypes (72% vs. 13.2%). The mutational frequency of serotype O12 was similar to that of other serotypes and thus could not explain the susceptibility to fosfomycin. As a number of epidemiological studies using various methods, especially ribotyping with EcoRI, have shown that most strains are similar, it has been suggested that a single strain of this serotype is widespread. However, in this study ribotyping with EcoRI and PvuII distinguished seven clones among 24 ticarcillin resistant serotype O12 isolates, although one ribotype predominated (67%). Thus the hypothesis of spread of one clone across Europe cannot explain the common resistance phenotype observed in different clones of serotype O12. Resistance of beta-lactams and aminoglycosides might be explained by greater receptiveness for transposable resistance mechanisms, and susceptibility to fosfomycin by increased permeability of the outer membrane.

Anti-Bacterial Agents↗

PubMed1994

[Triple shigellosis in the same patient contracted during operation "Turquoise" in Rwanda].

We report a case of shigellosis observed in a young French sanitary assistant, returning from a refugees camp in Goma after a 5-week stay. Three different species were isolated from stool samples: Shigella flexneri, S. boydii and S. sonnei. This observation raises the matter of a chemical prophylaxis during a short stay in developing countries where sanitary conditions are poor.

Adult↗

PubMed1992

[The transfusion card: value, limitations].

The transfusion-sheet is an important document which appears first in the French legislation on May 1985 the 17. Its aim is to keep a close watch over transfusion of red blood cells, platelet concentrates and fresh frozen plasma and also immunohematologic evolution of data for every patient. In spite of its importance for everyone in charge of transfusion practice (physicians, biologists, transfusion center,...), a lot of problems may be observed in the strict and complete updating of the document. Informatisation of all the steps of the medical and biological practice appears of crucial interest to perfect its use.

Blood Transfusion↗