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Biomedical subjects

P Galea

Publications and source records attributed to P Galea.

At least 19 recordsLinked to original sources
PubMed1996

Familial aplasia cutis congenita.

Two siblings with extensive aplasia cutis congenita of the extremities are described. These lesions healed spontaneously and in the older sibling at four years follow-up there was minimal scar tissue at the affected sites.

Ectodermal Dysplasia↗
PubMed1995

Phenotypic characterization of CD4+ T cells that exhibit a transendothelial migratory capacity.

The phenotype of CD4+ T cells capable of transendothelial migration was determined using an in vitro model system, in which cells migrate through a monolayer of endothelial cells (EC) on collagen gels. A specific subset of resting CD4+ memory T cells was found to migrate. T cells within this subset can be defined by the bright expression of CD11a, CD26, CD44, and CD49d. Additionally, the migratory CD4+ T cell population is largely CD58bright, CD31-, CD62L-, and is also enriched in cells that brightly express CD49c, CD49e, and CD49f. Only a minority of the cells are activated, as indicated by expression of CD69. The EC were found to play a central role in facilitating migration of this subset because selective enrichment of CD11abright, CD26bright, CD44bright, CD4+ T cells was not observed when cells migrated in the absence of EC. Activation of the T cells induced a modest degree of migration of an additional subset of CD45RA+, CD31+ naive T cells. In contrast, TNF-alpha activation of the EC increased the transendothelial migration of an additional subset of activated memory T cells that expressed CD69 and CD62L. Neither activation of the T cells, stimulation of the EC, nor the presence of macrophage inflammatory protein-1 alpha (MIP-1 alpha) or RANTES, however, altered the phenotype of the majority of the migratory CD4+ T cell population, which is characteristic of a particular stage of memory cell differentiation. These results suggest that CD4+ T cells acquire the capacity for transendothelial migration at a specific phase of maturation that is only minimally altered by the activation of either the T cell or the EC, or by the presence of specific chemokines in the subendothelial matrix.

Antigens, CD↗
PubMed1992

Randomised trial of continuous nasogastric, bolus nasogastric, and transpyloric feeding in infants of birth weight under 1400 g.

Forty three infants under 1400 g were fed by a bolus nasogastric, continuous nasogastric, or transpyloric route. There were more complications with transpyloric feeding and no identifiable benefits in the growth rate, oral energy input, or chosen biochemical indices of nutrition. Bolus or continuous nasogastric feeds rather than transpyloric are better routine methods in infants of low birth weight.

Energy Intake↗
PubMed1991

Neonatal listeriosis in Scotland.

Thirty-one cases of neonatal listeriosis occurred in Scotland between 1 January 1987 and 31 August 1989. In each of these, Listeria monocytogenes was cultured from blood, cerebrospinal fluid or both. No case of neonatal listeriosis occurred between 1 September 1989 and 31 July 1990, a statistically significant difference in incidence (p less than 0.001). A possible explanation may be that pregnant women adjusted their diet in accordance with the advice given by the Chief Medical Officer in his letter to General Practitioners of February 1989 entitled 'Food and Listeriosis'. Full clinical features and outcome of nineteen of the thirty-one cases were obtained from the paediatricians responsible for their care. Of these, sixteen were early onset and three late onset cases. There were eight deaths, all early onset cases. Two severely asphyxiated infants could not be resuscitated and of the five infants who required assisted ventilation from birth, four died. Four early onset and three late onset cases presented with pyogenic meningitis and all seven recovered without sequelae. It is concluded that when neonatal listeriosis presents as an asphyxiated infant who, after resuscitation, requires assisted ventilation, a fatal outcome is probable. When neonatal listeriosis presents as pyogenic meningitis, recovery without sequelae is the usual outcome.

Anti-Bacterial Agents↗
PubMed1990

Visceral leishmaniasis in a Scottish child.

A Scottish girl acquired visceral leishmaniasis (kala-azar) while on holiday in Majorca. She presented with the infection, six months later, in Scotland. Because of inexperience with the disease and a degree of scepticism unnecessary investigations were carried out resulting in a delay in treatment.

Female↗
PubMed1990

Normal growth and development in a child with Baller-Gerold syndrome (craniosynostosis and radial aplasia).

The cardinal features of the Baller-Gerold syndrome (MIM *21860) are craniosynostosis and radial aplasia. Only 12 cases have been published and these are roughly divisible into two groups: cases without any additional abnormalities and cases with a broad range of additional features. We describe a boy with craniosynostosis and radial aplasia alone and highlight genetic counselling difficulties presented by a sporadic case of this rare syndrome.

Abnormalities, Multiple↗
PubMed1989

Comparison of maximum aerobic power, maximum anaerobic power, and skinfold thickness of elite and nonelite junior wrestlers.

The purpose of this investigation was to identify physiologic differences between elite high school-age wrestlers and nonelite wrestlers of comparable age, weight, and training experience. Two groups of junior wrestler, elite (n = 18) and nonelite (n = 18) were measured for maximum aerobic power (treadmill run), maximum anaerobic power of the arms and legs (Wingate test), and skinfold thickness. On the average (+/- SE) elite juniors had a VO2max of 52.6 +/- 2.0 ml/kg.min-1, 376 +/- 20 W for arm power, and 540 +/- 25 W for leg power. The nonelite group had a VO2max of 51.5 +/- 1.4 ml/kg.min-1 and 331 +/- 22 W and 467 +/- 29 W for arm and leg power, respectively. Ttests were computed to identify differences between the groups. The results revealed significant differences in four skinfold thicknesses, absolute anaerobic leg power, and relative anaerobic power of arms and legs. It was concluded that relative maximum anaerobic power is distinctly greater in elite high school wrestlers than less successful peers. In light of the results, it may be of benefit for wrestlers of lower caliber to decrease body fat, increase fat-free weight, and increase total body power through training.

Adolescent↗
PubMed1988

Maternal narcotic abuse and the newborn.

In 50 infants born to women who continued to take heroin during all or part of their pregnancy the drug withdrawal symptoms were mild and were noted in 21 infants (42%). Only nine infants required treatment. Sudden infant death syndrome occurred in two infants at 4 and 6 months.

Adolescent↗