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Biomedical subjects

P Gallucci

Publications and source records attributed to P Gallucci.

5 recordsLinked to original sources
PubMed1996

Publication productivity of clinical and counseling psychologists.

Compared the research productivity of clinical versus counseling psychologists and found surprisingly few differences. A serendipitous finding was low productivity across the board and a question was raised about the success of the scientist-practitioner model in both clinical and counseling psychology doctoral programs in instilling a research/publication ethic among professional (as opposed to experimental, social, etc.) psychologists.

Authorship↗
PubMed1983

Synthesis and pharmacological evaluation of propranolol-cyclic analogues.

Three propranolol analogues, bearing the oxygen of the --OH group enclosed in a 1,4-dioxanic rigid system, were synthetized. The lack of beta-blocking activity found for these compounds demonstrates the important role played by a free--OH group in the drug-receptor interaction.

Adrenergic alpha-Antagonists↗
PubMed1983

The irreversible alpha-blocker benextramine interacts with two different thiol groups.

beta-Haloalkylamines bind at two sites on the adrenergic alpha-receptor, one related to the noradrenaline-recognition site and the other possibly concerned with the calcium channel. In order to verify whether this might apply to other alpha-blockers the tetramine disulfide benextramine was selected owing to its unprecedented covalent selectivity towards the adrenergic alpha-receptor. The fast acting beta-haloalkylamine DMPEA and the "classical" calcium antagonist verapamil were used for protection experiments against benextramine blockade of rat vas deferens adrenergic alpha-receptor. It was demonstrated that two target thiols are probably involved in benextramine binding and one of them might possibly be located at the periphery of, or masked within, the calcium channel which may be connected physiologically to the adrenergic alpha-receptor. However, the hypothesis that the present results could indicate the selective interaction of benextramine with two different subtypes of the adrenergic alpha-receptor is also discussed.

Adrenergic alpha-Antagonists↗