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Biomedical subjects

P Gangadharan

Publications and source records attributed to P Gangadharan.

At least 19 recordsLinked to original sources

Cancer of the Colon: 32 years of experience in Bombay, India.

Incidence rate of colon cancer is low in India compared to the Western countries. The dietary habits may be the protective factor in our population. During a 32 year period (1941-1972), 555 cases of colonic cancer were recorded at the Tata Memorial Hospital, Bombay. Among the social groups utilizing this hospital, the Parsis (Zoroastrians) have the highest incidence of colonic cancer. The frequency of cancer of the caecum and sigmoid are almost equal. Cancer of splenic and hepatic flexures are predominantly seen in men. Of the resected cases 50% survived for 5 years and 40% for 10 years. When cancer was localised, the 5 year survival rate was 64%. The 5 year survival rat among transverse colon cancer patients was 70%. The skin was the commonest site of a second cancer among colon cancer patients; the possible etiological association of these two cancers appears very intriguing.

Adolescent

Prognostic significance of blood vessel invasion in carcinoma of the breast in women.

Prognostic significance of blood vessel invasion in carcinoma of the female breast has been evaluated by study of 242 cases of radical mastectomy done at the Tata Memorial Hospital. The significance of axillary node involvement with the disease has been simultaneously evaluated. In the absence of blood vessel invasion and lymph node metastasis the 5 year survival rate was 98%. Compared with this, 5 year survival rate was reduced to 59% when the blood vessel invasion was present but no lymph node metastasis. Only 12% survived for 5 years when both blood vessels and lymph nodes were involved with the disease. The study indicated that blood vessel invasion in the primary breast carcinoma is more significant than lymph node metastasis.

Adult

Feasibility of undertaking cancer incidence studies in rural areas of India.

In the rural areas of developing countries, modern medical facilities are well below optimum levels and death registration is not mandatory. In India, as a result of such a situation, very few studies have been undertaken on the incidence of cancer in the rural population, though 80% of the people live in villages. The paper presents cancer incidence rates observed in a rural area of India by means of a method involving the use of paramedical personnel for initial screening, to minimize the cost. A statistical evaluation of the results shows that the method can be used for registering common sites of cancer in an area where conventional cancer registration methods are not applicable.

Humans