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P Garbutt

Publications and source records attributed to P Garbutt.

5 recordsLinked to original sources

Tissue characterization from ultrasound B-scan data.

An approach to ultrasonic tissue characterization, using textural features of the B-scan image, is described. Portions of a B-scan image, 64 X 64 pixels spatially by 8 bits deep, are acquired from regions of interest and subjected to computer analysis. A systematic approach to defining a set of 93 textural features of a B-scan is described and methods and criteria for selecting optimum combinations of these are discussed. As a test of its power, the approach has been applied to the discrimination between the B-scan textures corresponding to livers and spleens of normal humans and various measures of "success" have been quantified both on a "training set only" and on a "training set plus test set" basis. The overall test probability of success of 82% on a single image and 94% on a subject yielding multiple images indicates the potential of the techniques for conditions where a subtle but uniform change in parenchymal texture may be present.

Computers↗

Macrocytic megakaryocytes in cultures of S1/S1d bone marrow.

The thrombocytopoietic system of S1/S1d mice is characterized by macromegakaryocytosis and megakaryocytopenia, but the mechanisms responsible for reciprocal abnormalities of megakaryocyte number and size are unknown. These mice have a genetically determined abnormality of their hemopoietic microenvironment that can, in part, be reproduced as abnormal adherent stromal cells in bone marrow cultures. Cultures of bone marrow were therefore done to determine if the megakaryocytic abnormalities of S1/S1d marrow would also be reproduced in them. Cultures composed entirely of S1/S1d cells showed persistent macrocytosis of megakaryocytes when compared with cultures of normal +/+ marrow. At various times of culture, there were also reduced numbers of megakaryocytes, total cells, and granulocytes in the supernatants of S1/S1d cultures. Mixed cultures of S1/S1d and +/+ cells yielded inconclusive findings. The fact that macromegakaryocytosis occurred in cultures of S1/S1d marrow strongly suggests that its in vivo determinants were, in part, reproduced in culture.

Acetylcholinesterase↗