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P Genest

Publications and source records attributed to P Genest.

At least 37 records · Page 2Linked to original sources
PubMed1988

Prognostic significance of endometrial extension in carcinoma of the cervix.

A retrospective analysis of 343 consecutive patients with histologically proven carcinoma of the cervix, treated at the Ottawa General Hospital, was undertaken to evaluate the prognostic significance of endometrial extension. All these patient had a D + C as part of their work-up. Sixty-seven patients had a (+) D + C: 34/150 (23%) in Stage IB, 21/106 (20%) in Stage II, and 12/87 (14%) in Stage III. Survival was closely related to the D + C findings in early stages. In Stage IB, the 5-year survival of D + C (-) patients was 90% vs 50% in D + C (+) patients (P less than 0.003) and in Stage II, the 5-year survival was 77% and 55%, respectively (P = 0.089). There was, however, no difference in survival in Stage III patients (35% vs 29%). Pelvic failures were similar in both groups, stage for stage, but those with a (+) D + C had a higher incidence of distant metastasis. In Stage IB, distant metastases were found in 8.5% (10/116) of D + C (-) patients compared to 38% (13/34) in D + C (+) patients (P less than 0.001) and in Stage II, in 18.5% (16/85 and 33% (7/21) of the patients (P = 0.126), respectively. There was no difference in Stage III patients (28% vs 25%). This study suggests that endometrial extension is a significant prognostic factor in early stages and is associated with a higher risk of distant metastases. Management of these high risk patients is discussed.

Dilatation and Curettage↗
PubMed1987

Stage III carcinoma of the endometrium: a review of 41 cases.

Forty-one patients with clinical-pathological stage III carcinoma of the endometrium treated between January 1958 and December 1983 at the Ottawa General Hospital were analyzed. Twenty-three patients (56%) presented with clinical stage III and 18 (44%) with pathological stage III. The 5-year survival of all stage III patients was 35%. Patients with clinical stage III had a 5-year survival of 8% compared to 70% for patients with pathological stage III (P less than 0.01). Twenty-nine patients (71%) failed. The site of first recurrence was limited to the abdominal cavity in all but 6 patients (79%). The role of whole abdominal radiation is discussed.

Adenocarcinoma↗
PubMed1987

Intra-arterial cisplatin for bladder cancer.

Cisplatin (25 to 120 mg. per m.2) was injected into the internal iliac arteries of 33 patients with locally advanced bladder cancer. Of the patients 9 were inevaluable for response to the cisplatin, since they began radiotherapy to the bladder before course 2 of cisplatin as part of a preplanned therapeutic approach. One patient received the treatment as postoperative adjuvant therapy, 1 did not return for followup and 1 with metastatic disease did not undergo repeat cystoscopy. Of 21 evaluable patients 3 (14 per cent) achieved complete remission, 12 (57 per cent) achieved partial remission, 2 (14 per cent) were stable and 4 (19 per cent) failed. The response rate was higher in patients receiving 100 to 120 mg. per m.2 per course than in patients receiving lower doses (all except 1 of whom received 60 or less mg. per m.2 per course) (86 versus 64 per cent) and it was higher in patients without prior radiotherapy or chemotherapy. The response rate in patients with previously untreated invasive transitional cell carcinoma was 88 per cent. Of the 33 patients 21 were alive at last followup, with a median duration of followup of 32 weeks. Toxicity was dose-related and local neurotoxicity was excessive at cisplatin doses of 100 to 120 mg. per m.2. Diabetic patients were particularly prone to have neurotoxicity. Other toxicity generally was not severe and consisted of ototoxicity, nephrotoxicity, myelosuppression, nausea, vomiting and diarrhea. Even elderly patients and patients with cardiac disease tolerated the treatment well. We plan to proceed with further intra-arterial cisplatin studies in which all patients except those more than 80 years old will be treated with an intra-arterial cisplatin dose of 90 mg. per m.2 per course combined with radiotherapy with or without cystectomy.

Adult↗
PubMed1987

Prognostic factors in early carcinoma of the endometrium.

Two hundred forty-one patients with clinical-pathological Stage I and 58 patients with clinical-pathological Stage II carcinoma of the endometrium treated between January 1959 and December 1983 at the Ottawa General Hospital were analyzed. The adjusted survival rate at 5 years was 92% in patients with Stage I and 66% in patients with Stage II. In patients with Stage I, the most important prognostic factors were the histological grade of the tumor and the depth of myometrial invasion. In patients with Stage II, the single most important prognostic factor was the clinical extent of the disease. Grade and depth of myometrial invasion were also significant prognostic factors, particularly in patients with pathological Stage II. Combined surgery and radiation therapy was clearly superior to surgery alone in patients with Stage II but not in patients with Stage I, although, with long-term follow-up, our results may suggest improved survival in these patients as well.

Adult↗
PubMed1986

Transient heart failure in an adult with Kawasaki disease.

Kawasaki disease is a mucocutaneous lymph node syndrome with important cardiovascular complications that usually afflicts young children. We describe a 31-year-old woman who developed transient heart failure during the acute phase of Kawasaki disease. The diagnosis was supported by the presence of all six criteria of the disease: fever, conjunctivitis, strawberry tongue, cervical lymphadenopathies, truncal exanthem, and periungual membranous desquamation. Related clinical and laboratory findings included heart failure, arthralgias, transverse nail grooves, thrombocytosis, and elevated serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and bilirubin. Alternative diagnoses were excluded. During her acute febrile illness, the patient developed tachycardia, hypotension, pulmonary rales, S3 gallop, and hepatojugular reflux. The chest roentgenogram showed new Kerley A and B lines. A first-pass isotopic ventriculography showed diffuse hypokinesia and decreased ventricular ejection fractions; spontaneous recovery occurred after a few days. A coronarography performed two months later showed no aneurysmal dilatation. Kawasaki disease is a cause, albeit rare, of myocardial dysfunction in the adult human, and should be sought for actively in a patient with heart failure during the course of an acute febrile illness, associated with mucocutaneous changes.

Adult↗
PubMed1986

The preferential location of the human Y chromosome in somatic metaphase. I. Influence of Y polymorphism.

The location of the Y chromosome in metaphase figures was studied, with respect to its polymorphism, on 700 micrographs from blood lymphocyte cultures from 70 normal male members of seven Canadian family lines whose polymorphic Y chromosomes were inherited in a patrilinear fashion from seventeenth-century French ancestors. Three of these family lines were carriers of a long Y chromosome, two a small one, one had an average length Y and a seventh one had a satellited Y marker. The Y chromosome was peripheral in 75 to 90 per cent of the metaphase plates from each individual investigated. The long Y markers were more peripheral than the small ones while the average length Y chromosome had an intermediate position, whereas the satellited Y chromosome was located within the small group. The difference between the location of the long and the small Y chromosomes was highly significant. It is hypothesised that a heteromorphic Y might affect the nonrandom orientation of metaphasic chromosomes and favour meiotic nondisjunction and aneuploidy.

Cells, Cultured↗
PubMed1985

[Chromosomes and carcinogenesis. Study on the evolution of an epithelial cell line of porcine origin].

The PFT cell line was established in 1969 from diploid cells of the inner lining of a uterine tube of a 2 year-old sow and has been continuously subcultured more than 500 times over a decade. Three chromosomal rearrangements have occurred during this time. The first translocation was shown at the 100th passage with the concomitant and spontaneous release of an endogeneous type C virus. The second translocation was observed at the 290th passage along with the appearance of gap junctions and the induction of malignant tumors in athymic nude mice following the inoculation of PFT cells. The third translocation was found towards the 470th passage with the simultaneous appearance of annulate lamellae. Since the translocations were accompanied by the spontaneous release of a retrovirus and then by malignancy of PFT cells when inoculated in athymic nude mice, it is likely that the chromosomal abnormalities are associated with the viral carcinogenesis of the cell line. The third translocation appears to confirm the perenniality of the multistep evolution hypothesis of malignancy.

Animals↗
PubMed1985

The influence of the length of the human Y chromosome on spontaneous abortions. A prospective study in family lines with inherited polymorphic Y chromosomes.

Following reports indicating a close association between the presence of a long Y chromosome in males and the risk of spontaneous abortion in their female partners, the incidence of spontaneous fetal loss was investigated in four family lines whose patrilineary ancestors emigrated from France to Canada during the second half of the seventeenth century. In two of the lines the males were carriers of a Yq+, in the other two the males had a Yq- or a normal Y chromosome. Results showed that in one of family lines with a Yq+, 17/26 (65.4%) wives had 33 (2.8%) spontaneous abortions in 151 pregnancies, whereas in each of the three other family lines 7/30 (23.3%) wives aborted 8 (4.9%), 15 (7.5%) and 10 (5.7%) times in 165, 200 and 175 pregnancies respectively. The high incidence of fetal loss found in one of the family lines whose males have a long Y chromosome correlates with previous observations on the influence of Yq+ on spontaneous abortions, and draws attention to the inheritable nature of this peculiarity. However, the low incidence of miscarriages observed in the other family line carrying a Yq+ seems to indicate that long Y chromosomes are of various types and could be produced by several mechanisms. Yq- does not seem to represent an increased risk of pregnancy loss. Results also demonstrated that while a long Y chromosome may affect the viability of the zygote, it does not affect the fertility of its carrier.

Abortion, Spontaneous↗
PubMed1983

[Unusual chromosomal rearrangement. An autosomal telomeric translocation on a multicentury satellited Y (Yqs) chromosome].

A new born male infant with craniostenosis and minor phenotypic malformations was found to have a satellited Yq chromosome with, translocated on its satellite, a segment from the terminal part of the long arm of a presumed autosome 14. The rearrangement is de novo since the propositus' father has a non-rearranged satellited Y chromosome and he is, furthermore, a member of a family line in which a Yqs is transmitted in patrilineary fashion since 1668. Such and autosomal translocation on a satellited Y chromosome is a very rare event, because the abnormality makes up a double rearrangement on the same arm of a chromosome, with a three-century interval between the two phenomenons. A presumed partial trisomy 14q is associated with the clinical picture of the case.

Craniosynostoses↗
PubMed1983

[Absence of the palmar c triradius. Dermatoglyphic and geneologic study of a genetic character transmitted since the 17th century in a Quebec family].

A dermatoglyphic research on the absence of the palmar c-triradius was carried out in a Canadian family line originating from a French married couple who settled in the Quebec City area in 1649. Of the 51 individuals examined, 34 showed that c-triradius was missing on one or both palms. The study of the family tree and of the data confirms the hypothesis that an absent palmar c-triradius is an autosomal dominant trait transmitted by an heterozygous genotype with, in the present observation, an incidence of 66,6% and an estimated penetrance of 44,1%.

Chromosome Aberrations↗
PubMed1981

Nontumoral, benign ad malignant stages of transformation of a diploid pig cell line. A review.

The PFT cell line originated from diploid endometrial cells and was subcultured more than 500 times. Nontumoral, benign and malignant transformation appeared at different stages. Four populations (F1, F2, F3 and F4) of cells were demonstrated sequentially by chromosomes analysis. These consisted of eight phenotypes corresponding to the sequential appearance of markers which included three chromosomal aberrations. The PFT malignant transformation in vitro is a progressive process through qualitatively different stages and may reflect neoplastic development in vivo. It is suggested that the benign and malignant transformations were under separate genetic control since they occurred after two chromosomal translocations on two different chromosomes. The spontaneous expression of a pig endogenous type-C virus which occurred concomitantly with the first translocation appeared to be related to oncogenesis.

Animals↗
PubMed1981

[Further study on the nature of a multicentury small Y chromosome (author's transl)].

A study of a small Y chromosome, found in a family line established in Canada since 1664, and traced back in France in some descendants of a sixteenth century ancestor related to the canadian one, has shown, by C-, G- and Q-banding techniques, that it was deleted of the q12 segment. This study suggests that the del(Y)(q12) results from the oldest known chromosome aberration.

Chromosome Aberrations↗
PubMed1980

Production of tumors in hamsters by cells of a pig uterine tube line.

Tumorigenicity was investigated in a pig established cell line continuously subcultured more than 400 times. Tumors were not found in hamsters' cheek pouches inoculated with cells from the first 200 subcultures. Fibroma developed in five out of 13 animals (9/26 pouches) inoculated with cells of the 313th and 314th subcultures. Two chromosome markers were found in the 290th subculture, in the 313th subculture inoculum and in tumor cells.

Animals↗
PubMed1980

Multisequential transformation of a pig cell line (PFT): correlations between tumorigenicity and chromosome and ultrastructural markers.

Cells from representative subcultures of a continuous cell line of pig uterine tube (PFT) and carrying none, one, or two chromosome markers were inoculated in athymic nude mice (RCN) to determine the occurrence of the malignant transformation in this line. No tumors developed in mice after implantation of cells from either the 16th and 65th subcultures (no chromosome markers) or the 106th subculture (one chromosome marker, anchorage-dependent). Three adenomas (11.1%) were found in 27 mice that had been inoculated with anchorage-independent cells having one chromosome marker. Of 27 mice inoculated with cells showing two chromosome markers and gap junctions, 23 mice (85.1%) developed undifferentiated carcinomas. Ultrastructural traits and karyotypes of tumors were generally similar to those of the PFT cell inocula. However, annulate lamellae were found in 8 of 13 tumors examined by electron microscopy but were not seen in PFT cell inocula. The occurrence of a multisequential transformation was indicated by serial examination of the first 400 subcultures of the line and by comparison of the markers observed in three successive populations of cells differing in their genetic constitution.

Animals↗
PubMed1979

Chromosome variants and abnormalities detected in 51 married couples with repeated spontaneous abortions.

Chromosome analysis of 51 married couples with repeated spontaneous abortions revealed a normal female karyotype in all wives, whereas 39 (76.5%) husbands showed a normal Y chromosome, 10 (19.6%) a Yq+, one (1.9%) a Yqs and one (1.9%) two Y chromosomes. The high incidence of Yq+ found in this investigation correlates with previous reports and indicates that the risk of spontaneous abortions is increased when the male partner has a large Y chromosome.

Abortion, Habitual↗
PubMed1979

Structural abnormalities of the X-chromosome in a heifer.

Structural chromosome abnormalities, some of them unusual, were found in 18 (36%) of 50 photomicrographed mitotic cells of a blood lymphocyte culture from a three month old Holstein heifer affected with chronic tympanism of the rumen. The aberrations involved more specifically the X-chromosome. The etiology of the anomalies and the cause of their X-chromosome propension are of unknown nature.

Animals↗