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P Genet

Publications and source records attributed to P Genet.

At least 19 recordsLinked to original sources
PubMed1994

[Agranulocytosis induced by synthetic antithyroid drugs: efficacy of hematopoietic growth factors].

Agranulocytosis is the most serious problem, potentially fatal, that can occur during antithyroid drug therapy. The use of hematopoietic growth factors is an attractive approach to reduce the period of this drug-induced neutropenia. We report two cases of severe antithyroid drug-related agranulocytosis (granulocyte count < 0.1 x 10(9)/L) treated with Granulocyte Colony-Stimulating Factor (G-CSF) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). The delay to observe a granulocyte count superior to 1 x 10(9)/L was respectively 1 and 5 days. Our results, with others, clearly show that hematopoietic growth factors are effective in severe antithyroid drug-induced agranulocytosis.

Adult↗
PubMed1991

[Significance of hemiblock of the left branch during exercise].

There have been few reports of exercise induced left branch hemiblock. In order to assess its frequency and significance, a retrospective study of 8684 patients was undertaken: 24 cases (11 anterior and 13 posterior) were recensed. Nineteen of these patients had typical effort angina, 3 had a history of myocardial infarction and 3 had aortiocoronary bypass surgery. Twenty patients developed ST-T wave abnormalities included 11 ST segment depressions. Four patients refused coronary angiography: 3 of these patients had probable coronary artery disease (typical effort angina, positive exercise stress tests and in 1 case, inferior wall hypofixation during myocardial scintigraphy). Twenty patients underwent coronary angiography. In 2 patients, the exercise stress test was performed under Class IC antiarrhythmic therapy; 1 had a normal coronary angiogram and the other had patient coronary bypass graft. A control exercise stress test after withdrawal of drug therapy was negative in these 2 cases. The other 18 patients had significant coronary artery disease. The recording of left branch hemiblock during exercise stress testing would seem to indicate severe coronary artery narrowing (greater than or equal to 90% in 15 cases; greater than or equal to 80% in 3 cases) and left anterior hemiblock is indicative of left main coronary or proximal left anterior descending artery disease. In this series, medical therapy did not make exercise-induced left branch hemiblock regress, in contrast to aortocoronary bypass surgery and angioplasty.

Adult↗
PubMed1988

[Significance of exercise-induced arrhythmias].

Four personal cases of exercise-induced conduction defects occurring during stress testing are reported. The significance of these changes is discussed in the light of the authors' observations and of the cases published in the literature. The development of atrioventricular block is usually related to pre-existing disease of the conduction system, whilst left anterior or posterior hemiblock is usually due to transient ischaemia related to significant stenosis of the coronary artery responsible for the vascularisation of the relevant bundle branch (usually a proximal stenosis of the left anterior descending artery). Complete left bundle branch block may be due to a number of conditions (including chronic ischaemic heart disease).

Aged↗
PubMed1987

Relationship between external and internal parameters of exposure to manganese in workers from a manganese oxide and salt producing plant.

In a plant producing manganese (Mn) oxides and salts, 11 different workplaces were identified. The current exposure to airborne Mn (total dust, personal sampling, n = 80) varied from 0.07 to 8.61 mg/m3. The geometric mean and median values amounted approximately to 1 mg/m3 and the 95th percentile was 3.30 mg/m3. The concentration of Mn in blood (Mn-B) in a group of 141 Mn-exposed male workers ranged from 0.10-3.59 micrograms/100 ml compared to 0.04-1.31 micrograms/100 ml in a group of 104 control subjects. The ranges of the concentrations of Mn in urine (Mn-U) were 0.06-140.6 and 0.01-5.04 micrograms/g creatinine for the exposed and control groups, respectively. The average level of Mn-B in the Mn group was more than twice as high as in the control group (arithmetic mean, 1.36 vs 0.57 microgram/100 ml) and that of Mn-U was ten times higher in the Mn group (geometric mean, 1.56 vs 0.15 microgram/g creatinine). The Mn-B level did not change significantly after 8 h of Mn exposure, whereas the Mn-U level dropped rapidly when exposure ceased (half-life less than 30 h). On an individual basis, neither Mn-B nor Mn-U correlated with the current levels of Mn-air or duration of Mn exposure. There was also no relationship between Mn-B and Mn-U. On a group basis, there was no correlation between the mean Mn-B levels and the current levels of Mn-air at each workplace.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

Epidemiological survey among workers exposed to manganese: effects on lung, central nervous system, and some biological indices.

A cross-sectional epidemiological study was carried out among 141 male subjects exposed to inorganic manganese (Mn) in a Mn oxide and salt producing plant (mean age 34.3 years; duration of exposure, mean 7.1 years, range 1-19 years). The results were compared with those of a matched control group of 104 subjects. The intensity of Mn exposure was moderate as reflected by the airborne Mn levels and the concentrations of Mn in blood (Mn-B) and in urine (Mn-U). A significantly higher prevalence of cough in cold season, dyspnea during exercise, and recent episodes of acute bronchitis was found in the Mn group. Lung ventilatory parameters (forced vital capacity, FVC; forced expiratory volume in one second, FEV1; peak expiratory flow rate, PEFR) were only mildly altered in the Mn group (smokers) and the intensity and the prevalence of these changes were not related to Mn-B, Mn-U, or duration of exposure. There was no synergistic effect between Mn exposure and smoking on the spirometric parameters. Except for a few nonspecific symptoms (fatigue, tinnitus, trembling of fingers, increased irritability), the prevalence of the other subjective complaints did not differ significantly between the control and Mn groups. Psychomotor tests were more sensitive than the standardized neurological examination for the early detection of adverse effects of Mn on the central nervous system (CNS). Significant alterations were found in simple reaction time (visual), audioverbal short-term memory capacity, and hand tremor (eye-hand coordination, hand steadiness). A slight increase in the number of circulating neutrophils and in the values of several serum parameters (ie, calcium, ceruloplasmin, copper, and ferritin) was also found in the Mn group. There were no clear-cut dose-response relationships between Mn-U or duration of Mn exposure and the prevalence of abnormal CNS or biological findings. The prevalences of disturbances in hand tremor and that of increased levels of serum calcium were related to Mn-B. The response to the eye-hand coordination test suggests the existence of a Mn-B threshold at about 1 microgram Mn/100 ml of whole blood. This study demonstrates that a time-weighted average exposure to airborne Mn dust (total dust) of about 1 mg/m3 for less than 20 years may present preclinical signs of intoxication.

Adult↗
PubMed1985

Preclinical toxic effects of manganese in workers from a Mn salts and oxides producing plant.

The results of the present epidemiological study among 141 workers (mean age: 34 years) from a Mn salts and oxides producing plant in Belgium suggest that preclinical perturbations (lung function, CNS, biological parameters) may occur in subjects exposed to airborne Mn levels (7 years on the average) usually lower (total dust, geometric mean about 1 mg/m3, 95th percentile 3.3 mg/m3) than the levels actually (5 mg/m3) tolerated.

Adult↗
PubMed1985

Fertility of male workers exposed to mercury vapor or to manganese dust: a questionnaire study.

The fertility of male workers exposed to mercury vapor or to manganese dust was assessed with the use of the questionnaire developed by Levine et al [1980]. In the mercury group (concentration of mercury in urine ranging from 5.1 to 272.1 micrograms/g creatinine), no statistically significant difference was found between the observed number of children and that expected on the basis of the reproductive experience of a well-matched control group. On the contrary, by comparison with their corresponding controls, the manganese-exposed workers exhibited a statistically significant deficit in the number of children during their period of exposure to the metal. The airborne concentration of manganese dusts at the different workplaces ranged from 0.07 to 8.61 mg/m3 with a geometric mean of 0.94 mg/m3.

Adolescent↗