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Biomedical subjects

P Gerber

Publications and source records attributed to P Gerber.

At least 19 recordsLinked to original sources
PubMed1990

[Semiautomatic insulin injection equipment (pens)].

To the best of our knowledge, a good glycaemic control must be advised to avoid or delay the degenerative complications of diabetes, bearing in mind an increased risk of hypoglycaemias. Among other techniques, a treatment consisting of multiple injections (basal-bolus concept) is one way to achieve a good control. Although this form of treatment is rather restrictive (frequent blood glucose determinations), the use of pens makes it more acceptable. A fully informed and cooperative patient is a prerequisite before considering this particular type of insulin therapy which, however, is usually not very helpful for older diabetics. It is a misconception to think that every patient receiving insulin should do so with a pen, just as it is incorrect to recommend multiple injections for all type I diabetics. Whether such a therapeutic strategy is indicated should be established for each patient individually. In addition, the fashion for pens should not distract us from all the other problems associated with inadequate diabetic control, such as foot care and systematic blood pressure measurements.

Diabetes Mellitus, Type 1↗
PubMed1990

Symptomatology of late-life minor depression among primary care patients.

Patients of four general internists and four family physicians were interviewed by two psychiatrists to identify those suffering from depressive disorders. Nineteen elderly (60 years of age and older) patients and 22 younger (between 18 and 59 years of age) patients met Research Diagnostic Criteria (RDC) for minor depressive disorder, and 73 elderly and 79 younger patients had no psychiatric disorder. In general, the elderly depressed medical outpatients and the younger depressed medical outpatients had similar symptomatology, as did the elderly and nonelderly medical outpatients without psychiatric disorders.

Adult↗
PubMed1990

[Hydroxylapatite-coated total prosthesis of the hip].

Since 1987, 80 hydroxyapatite-coated (HA) cementless total hip prostheses have been implanted. Thirty patients were examined 21 months postoperatively and the results compared with data for uncoated prosthesis. Earlier mobilization and freedom from pain, together with evidence of bone ingrowth without connective tissue membrane formation, confirmed the benefits of HA-coated prostheses.

Aged↗
PubMed1989

[Mushroom ileus without previous intestinal obstruction].

A case is described of obstruction of the small bowel after consumption of 500 g edible mushrooms (Cantharellus cibarius). No fibrous bands or adhesions were found on laparotomy. When preparing the meal the mushrooms were not cut up, nor were they properly chewed due to the patient's defective dental prosthesis. 11 days after the meal the patient passed largely intact mushrooms. In retrospect the impacted mushrooms could be assumed on X-ray after barium meal. Since even without intra-abdominal adhesions impacted mushrooms can cause mechanical obstruction, it is recommended that mushrooms be cut up, chewed well and consumed only in moderate portions even when large quantities are available.

Adult↗
PubMed1989

[Experimental pancreatic duct occlusion with polyurethane].

Pancreatic transplantation requires an effective method to manage exocrine secretion. A new technique to eliminate the exocrine function of the pancreas by obstruction of the duct with polyurethane was investigated in terms of function, outcome and morphology. Polyurethane is an alcoholic solution of block copolymers with the property of polymerizing within 5-10 min. In this study the in-situ pancreatic tail model in dogs was utilized, the pancreatic duct was cannulated and injected with 2-3 ml of polyurethane. As a result, complete atrophy and fibrosclerosis of the exocrine tissue was obtained leaving islets well vascularized and functioning for the entire experimental periods. All animals remained normoglycemic and showed normal K-values. Amylase levels were found to be maximally elevated at 24 h and returned to normal within 2 weeks after duct occlusion. Insulin, glucagon and somatostatin levels remained normal. Because of its ability to effect a complete occlusion of the pancreatic ducts with subsequent atrophy of the exocrine gland and without notable disturbance of endocrine function, we feel that polyurethane solution is superior to previously used materials for this purpose.

Animals↗
PubMed1988

Hotson's syndrome--the "all-or-nothing" rule.

Whenever a plaintiff has lost a chance of a better medical result, which might have been achieved by prompt diagnosis and correct treatment, he or she must recover 100% of the award of damages provided that the plaintiff can prove that he or she had a better than 50% chance of an improved result.

Australia↗
PubMed1988

The enhancer in an MHC class II gene, in vitro and in mouso.

The E alpha class II gene of the major histocompatibility complex is expressed in a variety of immunocompetent cells. Part of the control of tissue-specific expression is mediated by a block of sequences found far upstream of the transcriptional startsite; this stretch is necessary for expression in the B lymphocytes of transgenic mice, but largely dispensable elsewhere. We review the evidence for the role of this region in E alpha transcription in transgenic animals, as well as data from transfections into tissue-culture cells, which indicate that this region has non-specific enhancer activity. We discuss possible models to explain how a non-specific enhancer can participate in cell-specific control.

Animals↗