Effect of carbon dioxide and various oxygen tensions on the respiratory activity of bone.
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Biomedical subjects
Publications and source records attributed to P Goldhaber.
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A miniaturized semiconductor probe was used to measure alveolar bone uptake of a bone-seeking radiopharmaceutical in dogs with destructive periodontal disease. Radiopharmaceutical uptake in localized, advanced disease was greater than in incipient disease and was generalized, with increased uptake occurring in radiographically normal areas and in areas with bone loss.
The possible implications of the assessment and diffusion of technology for dental research are explored in two areas: prevention of dental caries and prevention of periodontal disease. Future concepts and their potential alternatives for the profession, the public, and government agencies are examined in terms of the social, economic, and political aspects of dental health care delivery. Consideration is given to their impact on industry and education.
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Mouse bone collagenase was found to be tightly bound to a heparin-substituted gel at low ionic strength. The bond was reversible, however, and the collagenase could be elutted at high ionic strength. In addition to providing a method for purifying the enzyme with high yield, the results suggest that the strong ionic bond between heparin and collagenase may partially explain the mechanism wherein heparin enhances the activity of mouse bone collagenase.
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Bone-seeking radiopharmaceuticals were used together with clinical and radiographic procedures to study tooth development in dogs. Similarities in the pattern and time course of radiopharmaceutical uptake in jaw areas studied suggest that changes in alveolar bone metabolism are not closely related to eruption times of individual teeth.