PubMed Health⌕ Search

Biomedical subjects

P Grabar

Publications and source records attributed to P Grabar.

At least 19 recordsLinked to original sources
PubMed1985

[Prolonged survival of skin allografts in rats by injection of serum or a serum fraction extracted from pregnant rats].

This work report the partial purification of an alpha 2-macroglobulin present in the serum of allopregnant rats. Ultrogel filtration followed by immune absorption on different antisera were used giving a single band on polyacrylamide gel electrophoresis. This fraction was able to inhibit in vitro T cell cytotoxic response to allogenic cells. When administered repeatedly to rats it significantly increased the survival of skin allograft. This alpha 2-macroglobulin fraction isolated from allopregnant rats was denominated IRG to its graft rejection inhibitory activity.

Animals↗
PubMed1976

[Induction of immune tolerance by free unreactive haptens].

The injection of free non-reactive hapten, before immunization with the same hapten conjugated to one carrier protein, induces specific unresponsiveness to the hapten in Rats. Two haptens have been assayed: dinitrophenyl-Lysine and Arsonate-Tyrosine. In both cases, the Rats responded normally to the carrier but did not respond to the hapten. These results can be explained by assuming that the hapten blocks the specific receptors of the immunocompetent cells.

Animals↗