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Biomedical subjects

P Gratz

Publications and source records attributed to P Gratz.

6 recordsLinked to original sources
PubMed1991

Sonography and scintigraphy in the diagnosis of diseases of the major salivary glands.

This is a prospective study of 73 patients with diseases of the major salivary glands. The sonographic diagnosis could be confirmed by the course of the disease and/or the histologic result after operation in 67 (93%). In 29 patients, salivary gland scintigrams also were carried out. There was a tendency for signs of hypervascularization to be seen in patients with acute inflammation and reduction or loss of function in the presence of a chronic inflammation of the salivary glands. Scintigraphy did not provide diagnostic information on tumors of the salivary glands with regard to the type and location, with the exception of the Warthin's tumor. In selected cases it adds additional information, especially in functional therapy control.

Adenoma, Pleomorphic↗
PubMed1986

[Modern methods for the manufacture of therapeutic coagulation factors].

In a modern therapy concept coagulation factor concentrates are widely used for prophylaxis of bleeding events and in intensive care medicine. In the past their use was limited by the risk of transmitting virus diseases to the patient. Therefore, it was a challenge to modern plasma fractionation to develop purification processes which are able to eliminate and inactivate viruses. At present several methods for virus inactivation are used; their efficiency is not finally proven. Practical experience exists with a method in which viruses are inactivated by heat treatment in solution. A similar process is used since more than 40 years to produce albumin and was proven to be safe. Today, all coagulation factor preparations can be treated by this inactivation method and produced in large scale. Together with a high degree of viruses elimination during the purification process the therapy with coagulation factors has become much safer.

Antithrombin III↗
PubMed1981

[Factor VIII concentrate, highly purified and heated in solution (author's transl)].

A process is described to produce a highly purified factor VIII concentrate heated in solution. Pooled cryoprecipitate from citrated plasma is adsorbed on aluminum hydroxide gel. The fibrinogen is removed by heat denaturation in the presence of glycine; factor VIII is precipitated with sodium chloride from the supernatant. The precipitate is dissolved in a saccharose/glycine solution and heated at 60 degrees C for 10 h. The factor VIII is then separated by further precipitation with sodium chloride, the precipitate dissolved, dialysed and sterilized by filtration. The factor VIII concentrate contains approximately 6 units F VIII:C per mg protein. the ratio of F VIII R:Ag/F VIII:C is 3. The product is free from coagulable protein and gamma-globulins. The efficacy of the heating step in the reduction of the hepatitis B-infectious titre was proved in chimpanzees. For this purpose, hepatitis B virus was added to the pooled cryoprecipitate.

Drug Stability↗
PubMed1976

Computer-stored faculty publication file using the MT/ST in a medium-sized medical center library.

The Bowman Gray School of Medicine Library has implemented a computerized faculty publication file adapted from an existing system that utilized a Magnetic Tape/Selectric Typewriter for catalog card production and computer storage. The faculty publication file has provided printouts for the school's annual report and monthly faculty bulletins. After the data for all faculty bibliographies have been stored in the file, it will be possible to retrieve complete author and departmental listings. The file will be continuously updated by adding current citations and the bibliographies of new faculty members and by deleting data when faculty members leave the staff.

Cataloging↗