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Biomedical subjects

P Grella

Publications and source records attributed to P Grella.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Fetal malformations caused by oral anticoagulants during pregnancy. Report of a case].

The case of a newborn infant girl with a partial agenesis of the corpus callosum and hypoplasia of the nasal bones is reported. She was the product of a full-term pregnancy of a woman who had previously undergone mitral valve replacement with a Björk-Shiley prosthesis and had been maintained on oral anticoagulants (sodium warfarin) until the 38th week of gestation. This case underlines: 1) The need for maintaining an adequate anticoagulation in pregnant women with a mechanical prosthesis. 2) The potential risks of fetal malformations when the oral anticoagulants are given during the first trimester of pregnancy and of fetal hemorrhagic complications when these drugs are administered during the last two trimesters of gestation. 3) The lack of effective pharmacological alternatives to coumarin drugs, which can allow an adequate anticoagulation in the mother with minimal hazards for the fetus.

Abnormalities, Drug-Induced↗
PubMed1980

Modifications of the coagulation factors during normal and pathological pregnancies.

Levels of fibrinogen and fibrin/fibrinogen degradation products (F.D.P.) have been mesurated respectively by thrombin time and by staphylococcus clumping test in 33 pregnant patients, recovered in the Obstetric and Gynaecological Clinic - University of Padua, during the ninth month of pregnancy. A control group of 16 normal pregnancies, a second group of 12 hypertensive patients, and a third group of 15 pregnancies who had given birth to rather small babies for date, were considered. A significative increase (p less than 0,001) of the F.D.P. values was found both in the pregnant women with hypertension and in those with foetal insufficiency respect to the control group. The fibrinogen levels did not vary in any of the three groups.

Blood Coagulation Factors↗
PubMed1978

Premature labor and indomethacin.

Administration of indomethacin to 29 women in the 26th--37th week of gestation with premature labor contractions was followed in 26 by a significant decrease of uterine activity. The effect of therapy was monitored by serial external tocometry recordings and by plasma concentrations of estriol, h.P.L., alpha-fetoprotein, and estriol/creatinine ratio in urine. The labor was monitored by cardiotocography; the new born infants were examined by the pediatrician. Following oral indomethacin treatment (25 mg every 6 Hours for 5 days) no untoward effects was observed on maternal and fetal wellbeing during pregnancy and labor. Four out 29 newborn infants, all appropriate for gestational age of 36--40 weeks, had one-minute Apgar scores less than 7, cyanosis, tachypnea, hypoxemia and serious oxygen dependency for several days. All the infant survived. These abnormalities may be due to short-term exposure to indomethacin and consequent inhibition of cyclo-oxygenase, impairement of prostaglandin-dependent physiological regulation of vessel tone during fetal life and circulatory disorders at birth.

Apgar Score↗