Biomedical subjects
Publications and source records attributed to P Grimshaw.
This study examined the three-dimensional kinematics and motor development patterns in early walking gait longitudinally over 8 mo. and presents an example of walking development of one normal child which might be used for comparative purposes in the clinical assessment of gait.
This study assessed the development of coordination during the first 8 months of independent walking and identified potential hypotheses that may be tested by further research. The walking gait of a normal child was recorded on video at the onset of independent walking, and thereafter at monthly intervals over a period of 8 months. Video images were digitized and 3-dimensional coordinates obtained. The coefficient of variation was used to measure variability in the movement. Other variables studied included range of movement, relationships between angles, angular velocties, timing relationships, proportional distance and temporal phasing. By adopting a dynamical systems perspective, this study identified variables that challenged the stability of the locomotor system. Coordinative structures were observed to shift from one state to another from age 18 months; such mutations included decreased range of motion, hip knee angle relationship that resemble mature walking, relative time of peak angular velocity, and stability of angle angular velocity phasing.
Sideroxylonal C (3), a new phloroglucinol dimer, was isolated from the flowers of Eucalyptus albens through bioassay-guided fractionation. The structure elucidation was based on 1D and 2D NMR experiments, MS analysis, and comparison with sideroxylonals A (1) and B (2). Sideroxylonal C inhibited human plasminogen activator inhibitor type-1 at 4.7 microM without any significant effect on human tissue plasminogen activator.
Soccer players may develop recurrent hamstring injuries. This may be due to inadequate rehabilitation or to recurrent injury. In addition, following injury, the hamstring muscular complex may be permanently damaged, resulting in decreased strength, and increased likelihood of recurrent injury. Fourteen professional soccer players were assessed by clinical examination and by isokinetic testing with a Cybex II machine. Seven had suffered moderate or major hamstring injuries in the past year. There were seven controls. None of the hamstring group were currently suffering from an acute hamstring injury. The results of the two groups were compared. There were no differences in the mean results. This pilot study suggests that no permanent functional damage occurs to the muscular complex after moderate or major hamstring injuries after correct treatment. However, further research is required to confirm this.
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It is suspected that hydrogen cyanide (HCN) may be an important factor in incapacitating fire victims, but the effects of sublethal exposures are not well characterized. Also, the incapacitating effects of fire atmospheres result from exposure to a mixture of toxic products so that the contribution from each component is difficult to determine. The mechanisms of incapacitation in monkeys exposed to the pyrolysis products of polyacrylonitrile (PAN) were compared to those resulting from low level HCN gas exposures. The physiological effects of the PAN atmospheres were almost identical to those of HCN gas alone. They consisted of hyperventilation, followed by loss of consciousness after 1-5 min, bradycardia with arrhythmias and T-wave abnormalities, and were followed by a rapid recovery after exposure. Hydrogen cyanide is considered to be the major toxic product formed by the pyrolysis of PAN. It is suggested that HCN may produce rapid incapacitation at low blood levels of cyanide in fires, while death may occur later due to carbon monoxide poisoning or other factors.