Biomedical subjects

P Gruenberg

Publications and source records attributed to P Gruenberg.

3 recordsLinked to original sources

PubMed1981

Topical flurbiprofen or prednisolone. Effect on corneal wound healing in rabbits.

Flurbiprofen is a nonsteroidal anti-inflammatory (NSAI) agent currently undergoing clinical investigation. Anti-inflammatory steroids have long been known to delay the healing of corneal stromal wounds. This was designed to compare the effects of equipotent anti-inflammatory doses of flurbiprofen and of prednisolone acetate on the inflammation and the healing (as measured by the wound bursting pressure) or 4-mm through-and-through incisions treated four times a day for ten postoperative days. The results suggest that flurbiprofen and prednisolone are not different in their effect on both postoperative inflammation and postoperative wound healing. Since NSAI agents and steroids inhibit prostaglandin formation at different enzymatic steps, it is possible that prostaglandins not only are responsible for postoperative inflammation but also are required for postoperative wound healing.

Administration, Topical↗

PubMed1981

Increase in rabbit corneal curvature by heated ring application.

This study demonstrated that increases of corneal curvature in living rabbits could be induced through the application of heated brass rings. The peak increase averaged 10.5 D in a series of 19 eyes, as compared to the nontreated fellow eyes. This change tended to be transient, was not prolonged with the use of steroids locally, and tended to return to normal within two to three weeks. The mechanism of this change involved the creation of a rigid desiccated pseudo-limbus holding the cornea in the configuration of increased curvature. With the rehydration of the desiccated area, the cornea then reassumes its pretreated curvature and configuration. The application of the rings heated to about 98C produced a very low incidence of corneal ulceration. Further experiments showed that burn ulceration is a temperature-dependent phenomenon rarely found with application of heat less than 110C.

Animals↗

PubMed1981

Ophthalmometry without patient fixation.

Because of the asphericity of the cornea, proper ophthalmometry requires the visual axis of the eye, the optical axis of the ophthalmometer, and the corneal apex to be coincident. The animal subject and the human patient cannot always direct their visual axis to the axis of the instrument. This paper describes the attachment of a photographer's tripod pan arm to the Haag Streit ophthalmometer and the method devised, which allows accurate corneal curvature measurement in cases of nonfixating subjects.

Adult↗