Biomedical subjects

P Guibout

Publications and source records attributed to P Guibout.

12 recordsLinked to original sources

PubMed1986

[Diffusion of trimethoprim and sulfamethoxazole into the pleural fluid].

The level of Trimethoprim (TMP) and of Sulfamethoxazole (SMZ) in the fluid of both pleural effusion and plasma was determined in 7 patients on the first day of treatment consisting of two daily doses of 160 mg TMP and 800 mg SMZ. In 4 subjects, the levels were determined again on the third (J3) and fifth day of treatment (J5). Thus with TMP the ratio of pleural/plasma drug levels rose progressively from the first day of treatment to attain by 12 hours a mean value of 0.79 +/- 0.16; subsequently it stayed at about the same level for day 3 (J3) and day 5 (J5). As for SMZ, the ratio of the pleural plasma drug level reached a maximum at 8 hours on the first day of treatment (0.53 +/- 0.12) then rose progressively on day 3 (J3 0.58 +/- 0.06) and on day 5 to 0.71 (+/- 0.08). The levels of TMP in the pleural fluid were below those which are usually described in bronchial secretions. On the other hand those of SMZ are appreciably raised.

Drug Combinations↗

PubMed1983

[Value of the assay of pleural carcinoembryonic antigen for the diagnosis of neoplastic pleurisy. Correlation with plasma levels and anatomopathological results].

The authors specify the contribution of pleural carcinoembryonic antigen (CEA) assay in the diagnosis of malignant pleuritis by comparing it to plasma concentrations and pathologic findings. 45 patients with pleuritis were studied. Etiology was malignant in 15 and non-malignant in 27. Analysis of results shows that a pleural CEA concentration above 5 ng/ml is very suggestive of malignancy. Determination of the pleural CEA/plasmatic CEA ratio provides no additional information compared to pleural CEA assay alone.

Adenocarcinoma↗

PubMed1983

[Granular cell bronchial tumors. General features, developmental and therapeutic aspects. Apropos of 4 new cases].

The authors report 4 new cases of bronchial granular cell tumours. The course of these rare tumours is usually slow and benign. They are usually discovered at endoscopy. Surgery is the most radical therapeutic solution and is that most often used. The possibilities of endoscopic resection, use of the laser or therapeutic abstention with endoscopic surveillance must be reserved for cases where surgical operation is contraindicated. In addition, the authors report one case in which multiple chemotherapy appeared to result in disappearance of a granular cell bronchial tumour.

Adolescent↗

PubMed1983

[Pulmonary biopsy using thoracoscopy].

Pulmonary biopsies were taken under thoracoscopy from 16 patients presenting with insoluble diagnostic problems. This method enabled the authors to make a diagnosis, which was not contradicted by the course of the disease, in 14 cases of diffuse or circumscribed pathology touching the lung cortex. There was no major incident.

Biopsy↗

PubMed1977