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Biomedical subjects

P Gupte

Publications and source records attributed to P Gupte.

6 recordsLinked to original sources
PubMed1994

Do changes in end-tidal PCO2 quantitatively reflect changes in cardiac output?

In anesthetized patients, acute decreases in cardiac output (CO) are often reflected as decreases in end-tidal CO2 tension (PETCO2), but the quantitative relationship between the changes in CO and the changes in PETCO2 is uncertain. We hypothesize that a quantitative relationship can be demonstrated if timing of the measurements in each episode of hemodynamic perturbation is standardized. In 24 patients undergoing abdominal aortic aneurysm surgery with constant ventilation, we prospectively performed 33 measurements of CO, PETCO2, and CO2 elimination (VECO2) within 10 min of hemodynamic changes. The percent decrease in PETCO2 directly correlated with the percent decrease in CO (slope = 0.33, r2 = 0.82). Also, the percent decrease in VECO2 correlated with the percent decrease in CO similarly (slope = 0.28, r2 = 0.84). The changes in PETCO2 and VECO2 following hemodynamic perturbation were parallel. This finding suggests that decreases in PETCO2 quantitatively reflect the decreases in CO2 elimination.

Aged↗
PubMed1983

The automated metabolic profile.

The automated metabolic profile provides the physician with a comprehensive review and graphic display of the patient's nutritional status, energy expenditure, substrate utilization, and nutritional requirements. A paramedical assistant performs all data acquisition, anthropometric and indirect calorimetric measurements. Data reduction is performed on a standard microcomputer system utilizing off-the-shelf peripherals. A standardized graphic sheet is used for the printout. The automated metabolic profile is utilized before initiation of nutritional therapy and subsequently to record the progress. Its use optimizes the clinical management of patients needing both ventilatory and nutritional support. By its use, total parenteral nutrition can be tailored to the requirements of the critically ill patient.

Anthropometry↗
PubMed1981

Noninvasive cardiopulmonary monitoring.

Contrast dilution curves have been utilized for evaluation of hemodynamic function. Noninvasive techniques for this purpose usually have been qualitative, expensive, and cumbersome with minimal applicability to the newborn infant. The technique of roentgen densitometry has been utilized to screen children with heart murmurs. Characteristic curve patterns were identified for normal subjects and for patients with shunts with correlation to catheterization data. This technique is now being applied in a quantitative fashion to estimate cardiac output and left-to-right ductal shunts. Cardiac output volumes were inversely proportional to the difference of the second moments of the dilution curves obtained--the second moment being a measurement of the peak dispersion. The estimation of the percent of left-to-right shunt is related to the exponential decay of the left-sided curve.

Absorptiometry, Photon↗
PubMedDate not supplied

Automated immune profile.

A simple means of evaluating the immune function of critically ill patients has been designed. This system uses 22 input data that are derived from an assessment of humoral and cellular immunity and of the various factors known to influence the immune status. The profile allows quantification of the degree of immune depression as well as follow-up of the progression of the immune status.

Adolescent↗
PubMedDate not supplied

Systemic organ assessment using computerized profiles.

Clinical monitoring of isolated parameters may lead to erroneous conclusions or conflicting speculations about the patient's general physiological status. Data derived from two or three primary parameters may provide a better understanding of the patient's overall status. Four automated profiles have been designed to aid in the management of critically ill patients. Data obtained from simple blood and urinary tests are used to compute parameters for various physiologic, renal, respiratory, and metabolic functions. The derived data are plotted in hard-copy form. A sequential series of each profile assists the physician in making intelligent and rapid therapeutic decisions and in evaluating the effectiveness of this therapy.

Computers↗